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| 1 | Updates in the pathophysiological mechanisms of Parkinson's disease: Emerging role of bone marrow mesenchymal stem cells显示文摘AIM: To explore the approaches exerted by mesenchymal stem cells(MSCs) to improve Parkinson's disease(PD) pathophysiology.METHODS: MSCs were harvested from bone marrowof femoral bones of male rats, grown and propagated in culture. Twenty four ovariectomized animals were classified into 3 groups: Group(1) was control, Groups(2) and(3) were subcutaneously administered with rotenone for 14 d after one month of ovariectomy for induction of PD. Then, Group(2) was left untreated, while Group(3) was treated with single intravenous dose of bone marrow derived MSCs(BM-MSCs). SRY gene was assessed by PCR in brain tissue of the female rats. Serum transforming growth factor beta-1(TGF-β1), monocyte chemoattractant protein-1(MCP-1) and brain derived neurotrophic factor(BDNF) levels were assayed by ELISA. Brain dopamine DA level was assayed fluorometrically, while brain tyrosine hydroxylase(TH) and nestin gene expression were detected by semi-quantitative real time PCR. Brain survivin expression was determined by immunohistochemical procedure. Histopathological investigation of brain tissues was also done.RESULTS: BM-MSCs were able to home at the injured brains and elicited significant decrease in serum TGF-β1(489.7 ± 13.0 vs 691.2 ± 8.0, P < 0.05) and MCP-1(89.6 ± 2.0 vs 112.1 ± 1.9, P < 0.05) levels associated with significant increase in serum BDNF(3663 ± 17.8 vs 2905 ± 72.9, P < 0.05) and brain DA(874 ± 15.0 vs 599 ± 9.8, P < 0.05) levels as well as brain TH(1.18 ± 0.004 vs 0.54 ± 0.009, P < 0.05) and nestin(1.29 ± 0.005 vs 0.67 ± 0.006, P < 0.05) genes expression levels. In addition to, producing insignificant increase in the number of positive cells for survivin(293.2 ± 15.9 vs 271.5 ± 15.9, P > 0.05) expression. Finally, the brain sections showed intact histological structure of the striatum as a result of treatment with BM-MSCs. CONCLUSION: The current study sheds light on the therapeutic potential of BM-MSCs against PD pathophysiology via multi-mechanistic actions. | Hanaa H Ahmed Ahmed M Salem Hazem M Atta Emad F Eskandar Abdel Razik H Farrag Mohamed A Ghazy Neveen A Salem Hadeer A Aglan | 2016 | World Journal of Stem Cells2016，8，3： | 9 |
| 2 | Decreased apoptosis in advanced-stage/high-grade hepatocellular carcinoma complicating chronic hepatitis C is mediated through the downregulation of p21 ras显示文摘Objective and background: Although p21 ras has been reported to be upregulated in hepatocellular carcinoma complicating chronic hepatitis C type I, p21 ras has a different role in advanced stages, as it has been found to be downregulated. The goal of this study was to investigate the status of p21 ras in early-stage/low-grade and late-stage/high-grade hepatocellular carcinoma and its possible link to apoptosis. Material and methods: Thirty-five cases each of chronic HCV hepatitis type 4 (group I) and cirrhosis with hepatocellular carcinoma (HCC) complicating chronic HCV hepatitis (groups II and III) were immunohistochemically evaluated using a p21 ras polyclonal antibody. The apoptotic index was determined in histologic sections using the terminal deoxynucleotidyl transferase-mediated d-UTP biotin nick end labeling (TUNEL) assay. Results: Significant differences (P=0.001) were detected in p21 ras protein expression between the three groups. A near 2-fold increase in p21 ras staining was observed in the cirrhotic cases compared to the hepatitis cases, and p21 ras expression was decreased in the HCC group. p21 ras expression correlated with stage (r=0.64, P=0.001) and grade (r=-0.65, P=0.001) in the HCC group and grade in the HCV group (r=0.44, P=0.008). Both p21 ras expression and TUNEL-LI were significantly lower in large HCCs compared to small HCCs (P=0.01 each). The TUNEL values were negatively correlated with stage in the HCC group (r=-0.85, P=0.001). The TUNEL values were also negatively correlated with grade in both the HCV and HCC groups (r=0.89, P=0.001 and r=-0.53, P=0.001, respectively). The p21 ras scores were significantly correlated with the TUNEL-LI values in the HCC group (r=0.63, P=0.001) and HCV group (r=0.88, P=0.001). Conclusions: p21 ras acts as an initiator in HCC complicating type 4 chronic HCV and is downregulated with HCC progression, which most likely promotes tumor cell survival because it facilitates the downregulation of apoptosis with tumor progression. | Nahed Baddour Ebtehal Farrag Ahmed Zeid Essam Bedewy Yousry Taher | 2013 | Chinese Journal of Cancer Research2013，25，3： | 6 |
| 3 | Chronic intestinal failure and short bowel syndrome in Crohn’s disease显示文摘Chronic intestinal failure(CIF)is a rare but feared complication of Crohn’s disease.Depending on the remaining length of the small intestine,the affected intestinal segment,and the residual bowel function,CIF can result in a wide spectrum of symptoms,from single micronutrient malabsorption to complete intestinal failure.Management of CIF has improved significantly in recent years.Advances in home-based parenteral nutrition,in particular,have translated into increased survival and improved quality of life.Nevertheless,60%of patients are permanently reliant on parenteral nutrition.Encouraging results with new drugs such as teduglutide have added a new dimension to CIF therapy.The outcomes of patients with CIF could be greatly improved by more effective prevention,understanding,and treatment.In complex cases,the care of patients with CIF requires a multidisciplinary approach involving not only physicians but also dietitians and nurses to provide optimal intestinal rehabilitation,nutritional support,and an improved quality of life.Here,we summarize current literature on CIF and short bowel syndrome,encompassing epidemiology,pathophysiology,and advances in surgical and medical management,and elucidate advances in the understanding and therapy of CIF-related complications such as catheter-related bloodstream infections and intestinal failure-associated liver disease. | Aysegül Aksan Karima Farrag Irina Blumenstein Oliver Schröder Axel U Dignass Jürgen Stein | 2021 | World Journal of Gastroenterology2021，27，24： | 4 |
| 4 | Hypoglycemic and antioxidant activities of Caesalpinia ferrea Martius leaf extract in streptozotocininduced diabetic rats显示文摘Objective: To evaluate the antidiabetic and antioxidant ef ects of aqueous ethanolic extract of Caesalpinia ferrea(C. ferrea) leaf in normal and streptozotocin(STZ) induced diabetic rats.Methods: Male Sprague-Dawley rats divided into 6 groups of 6 rats each were assigned into diabetic and non-diabetic groups. Diabetes was induced in rats by single intraperitoneal administration of STZ(65 mg/kg body weight). C. ferrea extract at the doses of 250 and 500 mg/kg body weight was orally administered to both diabetic and non-diabetic animals for a period of 30 days. After completion of experimental duration serum, liver and pancreas were used for evaluating biochemical and histopathological changes.Results: Oral administration of C. ferrea leaf extract significantly reduced elevated serum glucose, α-amylase, liver function levels and signii cantly increased serum insulin, total protein and body weight as well as improved lipid proi le due to diabetes. Furthermore, the treatment resulted in a marked increase in glutathione peroxidase, superoxide dismutase, catalase and reduced glutathione, and diminished levels of lipid peroxidation in liver and pancreas of diabetic rats. Histopathological studies demonstrated the reduction in the pancreas and liver damage and coni rmed the biochemical i ndings.Conclusions: From the present study, it can be concluded that the C. ferrea leaf extract ef ectively improved hyperglycaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats. Hence, it can be used in the management of diabetes mellitus. | Sherien Kamal Hassan Nermin Mohammed El-Sammad Amria Mamdouh Mousa Maha Hashim Mohammed Abd el Razik Hussein Farrag Amani Nassir Eldin Hashim Victoria Werner Ulrike Lindequist Mahmoud Abd El-Moein Nawwar | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，6： | 3 |
| 5 | The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage显示文摘 | Ahmed O. Abdel-Zaher Randa H. Abdel-Hady Madeha M. Mahmoud Magda M.Y. Farrag | 2007 | Toxicology2007，，3： | 2 |
| 6 | Coronary artery ectasiadiagnosed using multidetector computed tomography : morphologyand relation to coronary artery calcification 显示文摘 | Farrag A Faramawy AE Salem MA | 2013 | Int J CardiovascImaging2013，29，2： | 1 |
| 7 | Stress And Strain Monitoring of Reinforced-Soil Test Wall 显示文摘 | FARRAG K ABU-FARSAKH M MORVANT M | 2004 | Transportation Research Record: Journal of the Transpor- tation Research Board2004，1868，： | 1 |
| 8 | Acculturative stress and depression in an elderly Arabic sample显示文摘 | Wrobel NH Farrag MF Hymes RW | 2009 | J Cross Cult Gerontol2009，24，3： | 1 |
| 9 | Application and assessment of a dipstick assay in the diagnosis of hydatidosis and trichinosis显示文摘 | Al-Sherbiny MM Farrag AA Fayad MH Makled MK Tawfeek GM Ali NM 2004 | 2004 | Parasitol Res2004，93，2： | 1 |
| 10 | Is routine dissection of level li- B and V-A necessary in patients with papillary thyroid cancer undergoing lateral neck dissection for FNA-confirmed metastases in other levels 显示文摘 | Farrag T Lin F Brownlee N | 2009 | World J Surg2009，33，8： | 1 |
| 11 | Is routine dissection of level II-B and V-A necessary in patients with papillary thyroid cancer undergoing lateral neck dissection for FNA-confirmed metastases in other levels显示文摘 | Farrag T Lin F Brownlee N | 2009 | World J Sur2009，33，8： | 1 |
| 12 | Kinematical limit analysis for design of soil nailed structures 显示文摘 | JURAN I BAUDRAND G FARRAG K | 1990 | Geotech Engrg Div ASCE1990，116，1： | 1 |
| 13 | The use of the modified hypo - osmotic swelling test for the selection of immotile testieular spermatozoa in patients treated with ICSI a randomized controlled study显示文摘 | Sallam HN Farrag A Agameya AF | 2005 | Human Reproduction2005，20，12： | 1 |
| 14 | Antifungal activity of peppermint and sweet basil essential oils and their major aroma constituents on some plant pathogenic fungi from the vapor phase 显示文摘 | Edris AE Farrag ES | 2003 | Nahr- ung2003，47，2： | 1 |
| 15 | The role of pre-operative CT-guided FNAB for parapharyngeal space tumors显示文摘 | FARRAG T Y LIN F R KOCH W M | 2007 | Otolaryngol Head Neck Surg2007，136，： | 1 |
| 16 | Comparative Histopathological and Histochemical Studies on IGR, Lufenuron and Profenofos Insecticide Albino Rats 显示文摘 | Abdel R Farrag Shehata EM | 2007 | J Appl Sci Res2007，3，5： | 1 |
| 17 | Development of an accelerated creep testing procedure for Geosynthetics, Part 1 :Testing 显示文摘 | Farrag K | 1997 | Geotechincal Testing Journal1997，20，4： | 1 |
| 18 | The use of the medifled hypo-osmotic swelling test for the selection of immotile testicular spermatozoa in patients treated with ICSI: a randomized con-trolled study显示文摘 | Sallam HN Farrag A Agameya AF | 2005 | Hum Repred2005，20，12： | 1 |
| 19 | Angiotensin II type 1 receptor gene polymorphism and telomere shortening in essentialhypertension 显示文摘 | Farrag W Eid M E1-Shazly S | 2011 | Mol Cell Biochem2011，351，12： | 1 |
| 20 | Egyptian artichoke volatile compounds protect against lead-induced hepatic and renal toxicity in male rats显示文摘 | Ghanem K Z Ramadan M M Farrag A R H | | 0，，02： | 1 |
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