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| 1 | Vasoactive intestinal peptide signaling axis in human leukemia显示文摘The vasoactive intestinal peptide (VIP) signaling axis constitutes a master 'communication coordinator' between cells of the nervous and immune systems.To date,VIP and its two main receptors expressed in T lymphocytes,vasoactive intestinal peptide receptor (VPAC)1 and VPAC2,mediate critical cellular functions regulating adaptive immunity,including arresting CD4 T cells in G 1 of the cell cycle,protection from apoptosis and a potent chemotactic recruiter of T cells to the mucosa associated lymphoid compartment of the gastrointestinal tissues.Since the discovery of VIP in 1970,followed by the cloning of VPAC1 and VPAC2 in the early 1990s,this signaling axis has been associated with common human cancers,including leukemia.This review highlights the present day knowledge of the VIP ligand and its receptor expression profile in T cell leukemia and cell lines.Also,there will be a discussion describing how the anti-leukemic DNA binding transcription factor,Ikaros,regulates VIP receptor expression in primary human CD4 T lymphocytes and T cell lymphoblastic cell lines (e.g.Hut-78).Lastly,future goals will be mentioned that are expected to uncover the role of how the VIP signaling axis contributes to human leukemogenesis,and to establish whether the VIP receptor signature expressed by leukemic blasts can provide therapeutic and/or diagnostic information. | Glenn Paul Dorsam Keith Benton Jarrett Failing Sandeep Batra | 2011 | World Journal of Biological Chemistry2011，2，6： | 4 |
| 2 | Estrogenic activity ofmusk fragrances detected by the E-screen assary using hu-man MCF-7cells显示文摘 | Bitsch N Dudas C Failing K | 2002 | Archives of Environmental Contamina-tion and Toxicology2002，43，： | 1 |
| 3 | Radiolabeling of magnetic particles with rhenium-188 for cancer therapy显示文摘 | Gayle Pauer Sarah Failing | 2001 | Journal of Magnetism and Magnetic Materials2001，225，： | 1 |
| 4 | Uric acid validation and appli- hemodynamic staging 显示文摘 | Anker S D and survival Doehner W Rauchhaus in chronic heart fail cation in metabolic functional ure and M | 2003 | Circulation2003，107，15： | 1 |
| 5 | An application of pattern mapping to planemotion显示文摘 | FAIL R W TAYLOR C E | 1990 | Experimental Mechanicals1990，12，： | 1 |
| 6 | Mechanisms of intestinal phos- phate transport in small ruminants显示文摘 | Schroder B Kappner H Failing K | 1995 | British Journal of Nutrition1995，74，5： | 1 |
| 7 | IgG and IgM levels in dairy cows during the periparturient period显示文摘 | M. Herr H. Bostedt K. Failing | 2011 | Theriogenology2011，，2： | 1 |
| 8 | Factors causing patients to delay Seeking treatment after suffering a stroke显示文摘 | John M Palmer P Faile E | 2005 | W V Med J2005，101，1： | 1 |
| 9 | Antecedent hypoglycemiaimpairs autonomic cardiovascular function: Implications for rigorous glycemic control显示文摘 | Adler G K Bonyhay I Failing H | 2009 | Diabetes2009，58，11： | 1 |
| 10 | From equipment to infrastructure: community energy management and greenhouse gas emission reduction显示文摘 | Mark Jaccard Lee Failing Trent Berry | 1997 | Energy Policy1997，，13： | 1 |
| 11 | Validity and reliability of estimating the Scandinavian stroke scale score from medical records 显示文摘 | Barber M Fail M Shields M | 2004 | Cerebrovas Dis2004，17，2： | 1 |
| 12 | Hepatobiliaryelimination of bile acid-modified oligodeoxynucleotides in Wistarand TR rats : evidence for mrp2 as carrier for oligodeoxynucleoti-des显示文摘 | LISCHKA K STARKE D FAILING K | 2003 | Biochem Pharm2003，66，4： | 1 |
| 13 | A study of thecrystal and molecular structures of phenols with onlyintermolecular hydrogen bonding 显示文摘 | PROUT K FAIL J JONES R M | 1988 | J Chem Soc PerkinTrans II1988，，3： | 1 |
| 14 | New approach to preoperative vascular exclusion for carotid body tumor 显示文摘 | Tripp HF Jr Fail PS Beyer MG | 2003 | J Vase Surg2003，38，： | 1 |
| 15 | Characterization of the proliferation state in canine mammary tumors by the standardized AgNOR method with postfixation and immunohistologic detection of Ki - 67 and PCNA显示文摘 | LOHR CV TEIFKE JP FAILING K | 1997 | Vet Pathol1997，34，3： | 1 |
| 16 | Transanal endoscopic drainage of abdominopelvic sepsis 显示文摘 | Abbas MA Fails G | 2008 | JSLS2008，12，3： | 1 |
| 17 | Primary suture of the operative wounds after haem orrhoidectomy显示文摘 | Failes D | 2004 | Aust J Surg2004，36，5： | 1 |
| 18 | Vascularity index distribution within the testis: a technique for guiding testicular sperm extraction显示文摘 | Eytan O Har toov J Fail G et aI | 2001 | Ultrasound Med Biol2001，27，9： | 1 |
| 19 | Nitrofurazone: reproductive assessment by continuous breeding in Swiss mice 显示文摘 | GEORGE 3 D FAIL P A GRIZZLE T B | 2007 | Fundamental and Applied Toxicology2007，34，1： | 1 |
| 20 | New approach to preoperalive vascular exclusion for carotid body tumor显示文摘 | Tripp HF Jr Fail PS Beyer MG et a | 2003 | J Vasc Surg2003，38，2： | 1 |
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