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| 1 | Reduced bone mineral density and altered bone turnover markers in patients with non-cirrhotic chronic hepatitis B or C infection显示文摘AIM: Previous studies suggest that loss of bone mineral density (BMD) frequently occurs in patients with chronic viral liver disease, presenting with histologically proven liver cirrhosis. However, little is known about the occurrence of bone disease in non-cirrhotic patients with chronic hepatitis B or C. Therefore, it was the aim of this study to evaluate this particular population for BMD and bone turnover markers.METHODS: Biochemical markers of bone turnover and BMD were measured in 43 consecutive patients with HCV (n = 30)or HBV (n = 13) infection without histological evidence for liver cirrhosis. Mean age was 49 years (range 26-77 years). BMD was measured by dual X-ray absorptiometry in the femoral neck (FN) and the lumbar spine (LS) region. In addition, bone metabolism markers were measured.RESULTS: BMD was lowered in 25 (58%) of the patients with chronic hepatitis B or C (FN: 0.76 (0.53-0.99); LS:0.96 (0.62-1.23) g/cm2). Eight (32%) osteopenic patients were diagnosed with osteoporosis. Bone-specific alkaline phosphatase (P = 0.005) and intact parathyroid hormone (iPTH) (P = 0.001) were significantly elevated in the more advanced stages of fibrosis. Mean 7-score value was lower in patients with chronic hepatitis C as compared to patients suffering from chronic hepatitis B; however, the difference was not statistically significant (P = 0.09).CONCLUSION: There was a significantly reduced BMD in non-cirrhotic patients with chronic hepatitis B or C infection. Alterations of bone metabolism already occurred in advanced liver fibrosis without cirrhosis. According to our results, these secondary effects of chronic viral hepatitis should be further investigated. | Ingolf Schiefke Andreas Fach Marcus Wiedmann Andreas V.Aretin Eva Schenker Gudrun Borte Manfred Wiese Joachim Moessner | 2005 | World Journal of Gastroenterology2005，11，12： | 23 |
| 2 | Evaluation of the'GeneDisc” real-time PCR system for detection of en-terohaemorrhagic Escherichia coli (EHEC) O26,O103,O111,O145 and O157 strains according to their virulence markers and their O-and H-antigen-associated genes显示文摘 | BEUTIN L JAHN S FACH P | | 0，，04： | 1 |
| 3 | Delivery strategies to achieve therapoutic myocardial angiogenesis显示文摘 | Kornowski R Fachs S Leon MB | 2000 | Circulation2000，101，3： | 1 |
| 4 | Polymerase chain reactin for Salmonella virulence-associated plasmid genes:a new tool in Salmonella epidemiolygy显示文摘 | REXACH L DILASSIER F FACH P | 1994 | Epidemiolog Infect1994，112，： | 1 |
| 5 | Efficient secretion of biologically active recombinant OB protein (Leptin) in Escherichia coil, purification from the peripiasm and characterization 显示文摘 | Guisez Y Fache I Campfield L A | 1998 | Protein Expression and Purification1998，12，： | 1 |
| 6 | Comparison of different PCR tests for detecting Shigatoxin-Producing Escherichia coli O157 and development of an ELISA-PCR assay for specific identification of the bacteria显示文摘 | Perelle S Grout J | 2003 | Journal of Microbiological Methods2003，55，： | 1 |
| 7 | Diagnostic real-time PCR for detection of Salmonella in food显示文摘 | Malorny B Paccassoni E Fach P | 2004 | Applied and Environmental Microbiology2004，70，12： | 1 |
| 8 | Detection by in vitro amplification of the alpha-toxin (phospholipase C)gene from Clostridium perfringens 显示文摘 | GUILLOU J P | 1993 | J Appl Bacteriol1993，74，： | 1 |
| 9 | Synthesis of TS-1 in fluoride medium,A new way to a cheap and efficient catalyst for phenol hydroxylation显示文摘 | Grieneisen J L Kessler H Fache E | 2000 | Microporous and Mesoporous Materials2000，37，3： | 1 |
| 10 | Diagnostic real- time PCR for detection of Salmonella in food显示文摘 | MALORNY B PACCASSONI E FACH P | 2004 | Applied and Environmental Microbiology2004，70，12： | 1 |
| 11 | Adaptive frequency sampling algorithm for fast and accurate S-parameter modeling of general planar structure显示文摘 | DHAENE T UREEL J FACHE N | 1995 | IEEE MTT-S International Microwave Symposium Digest1995，3，： | 1 |
| 12 | Genotypes and virulence characteristics of Shiga toxin-producing Escherichia coli O 104 strains from different origins and sources 显示文摘 | Miko A Delannoy S Fach P | 2013 | Int J Med Microbiol2013，303，8： | 1 |
| 13 | Comparison of different PCR tests for detecting Shiga toxin - Producing Escherichia coli O157 and development of an ELISA - PCR assay for specific identification of the bacteria 显示文摘 | Fach P Perelle S Grout J | 2003 | J Microbiol Methods2003，55，： | 1 |
| 14 | Comparison of different PCR tests for detecting Shiga toxin-producing Escherichia coli 0157 and development of an ELISA- PCR assay for specific identification of the bacteria 显示文摘 | Fach P Perelle S Grout J | 2003 | J Microbiol Methods2003，55，2： | 1 |
| 15 | Enantioselective Catalytic Reduction of Ketones Using C2-Symmetric Diamines as Chiral Ligands显示文摘 | Gamez P Fache F Mangeney P lemaire M | 1993 | Tetrahedron Lett1993，34，43： | 1 |
| 16 | SVISS--A novel transient gene silencing system for gene function discovery and validation in tobacco plants 显示文摘 | Gossele V Fache 1 Meulewaeter F | 2002 | Plant J2002，32，5： | 1 |
| 17 | Diagnostic real-time PCR of Salmonella in food显示文摘 | Malorny B Paccassoni E Fach P | 2004 | Appl Environ Microbiol2004，70，： | 1 |
| 18 | Reduced numbers of circulating endothelial progenitor cells in patients with coronary artery disease associated with long-term statin treatment显示文摘 | Hristov M Fach C Becker C | 2007 | Atherosclerosis2007，192，： | 1 |
| 19 | Detection by invitroamplification of the alpha toxin (phospholipase C ) gene from Clostridium peoCringens 显示文摘 | Fach P GuiUou JP | 2003 | Jappl Bacte- riol2003，74，5： | 1 |
| 20 | Flavonoid biosynthe- sis in petals of Rhododendron simsii 显示文摘 | DECOOMAN L EVERACRT E S W FACHE P | 1993 | Phytochemistry1993，33，： | 1 |
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