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| 1 | Hepatitis C virus resistance to new specifically-targeted antiviral therapy: A public health perspective显示文摘Until very recently, treatment for chronic hepatitis C virus(HCV) infection has been based on the combination of two non-viral specific drugs: pegylated interferon-α and ribavirin, which is effective in, overall, about 40%-50% of cases. To improve the response to treatment, novel drugs have been designed to specifically block viral proteins. Multiple compounds are under development, and the approval for clinical use of the first of such direct-acting antivirals in 2011(Telaprevir and Boceprevir), represents a milestone in HCV treatment. HCV therapeutics is entering a new expanding era, and a highly-effective cure is envisioned for the first timesince the discovery of the virus in 1989. However, any antiviral treatment may be limited by the capacity of the virus to overcome the selective pressure of new drugs, generating antiviral resistance. Here, we try to provide a basic overview of new treatments, HCV resistance to new antivirals and some considerations derived from a Public Health perspective, using HCV resistance to protease and polymerase inhibitors as examples. | Karina Salvatierra Sabrina Fareleski Alicia Forcada F Xavier López-Labrador | 2013 | World Journal of Virology2013，2，1： | 2 |
| 2 | The Effect of Melatonin on the Secretion of Progesterone in Sheep and on the Development of Ovine Embryos in Vitro显示文摘 | Abecia J A Forcada F Zuniga O | 2002 | Vet Res Commun2002，26，2： | 1 |
| 3 | Repeated superovulation using a simplified FSH/e CG treatment for in vivo embryo production in sheep显示文摘 | Forcada F Ait Amer-Meziane M Abecia J A | 2011 | Theriogenology2011，75，4： | 1 |
| 4 | Repeated superovu-lation using a simplified FSH/eCG treat-ment for in vivo embryo production in sheep显示文摘 | FORCADA F AIT AMER-MEZIANE M ABECIA JA | 2011 | Theriogenology2011，75，4： | 1 |
| 5 | Ge- netic relationships and population structure of local olive tree ac- cessions from Northeastern Spain revealed by SSR markers 显示文摘 | MARTI A F I FORCADA C F I COMPANY R S I | 2014 | Acta Physiologiae Plantarum2014，37，1： | 1 |
| 6 | Pharmaceutical control of reproduction in sheep and goats显示文摘 | Abecia J A Forcada F Gonzdlez-Bulnes A | 2011 | Vet Clin North Am Food Anita Practice2011，27，1： | 1 |
| 7 | Undernutrifion and exogenousmelatonin can affect the in vitro developmental competence of ovineoocytes on a seasonal basis 显示文摘 | Vazquez M1 Forcada F Casao A | 2010 | Reprod Domest Anita2010，45，4： | 1 |
| 8 | The effect of melatonin on thesecretion of progesterone in sheep and on the development of ovineembryos in vitro 显示文摘 | Abecia J A Forcada F Zuniga O | 2002 | Vet Res Commun2002，26，2： | 1 |
| 9 | Effect of level dietary energy and protein on embryo survival and progesterone production on day eight of pregnancy in Rasa Aragonesa ewes 显示文摘 | Abecia J A Lozano J M Forcada F | 1997 | Anim Reprod Sci1997，48，24： | 1 |
| 10 | Non-invasive assessment of atherosclerotic plaques effects on the segment-to-segment human carotid visco-elasticity and filtering显示文摘 | Bia D Pessana F Forcada P | 2010 | Conf Proc IEEE Eng Med Biol Soc2010，20，10： | 1 |
| 11 | Effect of melatonin treatment in spring and feed intake on wool growth and thyroxine secretion in Rasa Aragonesa ewes显示文摘 | Abecia J A Ziga O Forcada F | 2001 | Small Rumin Research2001，41，： | 1 |
| 12 | The effect of me- latonin treatment on wool growth and thyroxine se- cretion in sheep显示文摘 | Abecia J A Valares J A Forcada F | 2005 | Small Ruminant Research2005，56，： | 1 |
| 13 | Effect of undernutrition on uterine progesterone and oestrogen receptors and on endocrine profiles during the ovine oestrous cycle显示文摘 | Sosa C Abecia J A Forcada F | 2006 | Reprod Fertil Dev2006，18，4： | 1 |
| 14 | Repeated surgical embryo recovery and embryo production in rabbits显示文摘 | FORCADA F LOPEZ M | 2000 | Anim Reprod Sci2000，64，12： | 1 |
| 15 | The effect of melatonin treatment on wool growth and thyroxine secretion in sheep显示文摘 | Abecia J A Valares J A Forcada F | 2005 | Small Rumin Res2005，56，： | 1 |
| 16 | Effect of melatonin treatment in spring and feed intake on wool growth and thyroxine secretion in Rasa Aragon- esa ewes 显示文摘 | J A Abecia O Ztifiiga F Forcada | 2001 | Small Ruminant Research2001，41，3： | 1 |
| 17 | Theeffect of melatonin on wool growth and thyroxine se-cretion in sheep显示文摘 | ABECIA J A VALARES J A FORCADA F | 2005 | Small Rumin Res2005，56，： | 1 |
| 18 | The effect of melatonin treatment on wool growth and thyroxine secretion in sheep 显示文摘 | J A Abecia J A Valares F Forcada | 2005 | Small Ruminant Research2005，56，13： | 1 |
| 19 | The effect of melatonin on the secretion of progesterone in sheep and on the development of ovine embryos in vitro显示文摘 | Abecia JA Forcada F Zuniga O | 2002 | Vet Res Commun2002，26，2： | 1 |
| 20 | Repeated superovulation of high-prolificacy Rasa Aragonesaewes before culling as an inexpensive way to obtain high-quality embryos 显示文摘 | Forcada F Abecia JA Lozano JM | 2000 | Livestock ProductionScience2000，，66： | 1 |
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