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| 1 | RAAS and adrenergic genes in heart failure: Function, predisposition and survival implications显示文摘It is well appreciated that several neurohormones and signaling cascades are activated that promote long-term deterioration of cardiac function and structure. Activation of the renin-angiotensin-aldosterone system (RAAS) and the adrenergic system is closely related to heart failure. Common gene variants that encode neurohormonal, adrenergic and intracellular proteins have been demonstrated to modulate the course and consequences of heart failure. However, the literature is replete with conflicting results and it remains uncertain as to whether particular gene variants predispose heart failure. Therefore, the main purpose of this review was to discuss the effects of single nucleotide polymorphisms (SNPs) that are located in genes encoding elements of the RAAS and the adrenergic system on the predisposition to and survival from heart failure. Most studies indicate that common SNPs encoding elements of the RAAS and the adrenergic system do not predispose individuals to heart failure. Conversely, it has been demonstrated that ARB1 Arg389Gly, GRK5 Gln41Leu, ACE I/D, CYP11B2 C-344T and AGTR1 A+1166C modulate pharmacological responses and have a considerable impact on cardiacrelated survival. It should not be expected, however, that a single polymorphism determines survival, given that multiple gene products and environmental factors contribute to the pathogenesis of heart failure. Therefore, future studies should consider the interaction effects of multiple genes in populations that are as homogeneous as possible with respect to environmental characteristics. | Alberto J Alves Nir Eynon José Oliveira Ehud Goldhammer | 2010 | World Journal of Cardiology2010，2，7： | 3 |
| 2 | Genes for Elite Power and Sprint Perfonnance:ACTN3 Leads the Way 显示文摘 | Eynon N Hanson ED Lucia A | 2013 | Sports Med2013，43，9： | 1 |
| 3 | Impact of a physical fitness program in a blue-collar worksite显示文摘 | Eddy JM Eynon D | 1990 | Health Value1990，14，3： | 1 |
| 4 | Digital natives:where is the evidence?显示文摘 | Helsper E J Eynon R | 2010 | British Educational Research Journal2010，36，3： | 1 |
| 5 | Altering the rest interval during high-intensity interval training does not affect muscle or performance adaptations显示文摘 | EDGE J EYNON N MCKENNA M J | 2013 | Exp Physiol2013，98，2： | 1 |
| 6 | Genes and elite athletes sa roadmap for future research 显示文摘 | Eynon N Ruiz JR Oliveira L | 2011 | J Physiol2011，589，13： | 1 |
| 7 | Cough associated with ACE inhibitor:Increased frequency in renal failure 显示文摘 | Soroosian M Eynon CA Webb DJ | 1991 | Eur J Inter Med1991，2，： | 1 |
| 8 | Perceptions of sole practitioners on ethics training in the profession显示文摘 | Eynon G Hill N.T Stevens K.T | | 0，，04： | 1 |
| 9 | A gene expression signature that predicts the future onset of drug-induced renal tubular toxicity显示文摘 | Fielden MR Eynon BP Natsoulis G | 2005 | Toxicol Pathol2005，33，6： | 1 |
| 10 | ACTN3 R577X polymorphism and Israeli top-level athletes 显示文摘 | Eynon N Duarte lA Oliveira 1 | 2009 | Int 1 Sports Med2009，30，9： | 1 |
| 11 | The ACTN3 R577X polymorphism across three ~oups of elite male European athletes 显示文摘 | Eynon N Ruiz lR Femia P | 2012 | PLoS One2012，7，43： | 1 |
| 12 | The variability of rainfall acidity显示文摘 | EYNON B P SWITZER P | 1983 | Canadian Journal of Statistics1983，11，1： | 1 |
| 13 | A typology of young people' s Inter- net use: Implications for education显示文摘 | Eynon R Malmberg L E | 2011 | Computers & Educa- tion2011，56，3： | 1 |
| 14 | RAAS and adrenergic genes in heart failure:Function, predisposition and survival implications显示文摘 | Alves AJ Eynon N Ofiveira J | | World J Cardiol0，2，7： | 1 |
| 15 | The response of circulating brain natriuretic peptide to academic stress in college students显示文摘 | Amir O Sagiv M Eynon N | 2010 | Stress2010，13，1： | 1 |
| 16 | Triangulated spatial models and neighborhood search:an experimental comparison with quadtrees显示文摘 | Jones C B Ware J M Eynon C D | 1999 | The Visual Computer1999，15，5： | 1 |
| 17 | Genes for elite pow- er and sprint performance: ACTN3 leads the way显示文摘 | Eynon N Hanson ED Lucia A | 2013 | Sports Med2013，43，9： | 1 |
| 18 | Digital natives: where is the evidence? 显示文摘 | HELSPER E J EYNON R | 2010 | British educational research journal2010，36，3： | 1 |
| 19 | Is there an ACE ID-ACTN3 R577X polymorphisms interaction that influences sprint performance? 显示文摘 | Eynon N Alves Aj Yamin C | 2009 | Int 1 Sports Med2009，30，12： | 1 |
| 20 | Is the interaction between HIFIA P582S and ACTN3 R577X determinant for power/sprint performance? 显示文摘 | Eynon N Alves Aj Meckei Y | 2010 | Metabolism2010，59，6： | 1 |
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