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| 1 | Linoleic acid metabolic pathway allows for an efficient increase of intramuscular fat content in pigs显示文摘Background: Intramuscular fat(IMF) content is a relevant trait for high-quality meat products such as dry-cured ham,but increasing IMF has the undesirable correlated effect of decreasing lean growth.Thus,there is a need to find selection criteria for IMF independent from lean growth.In pigs,the proportion of linoleic(C18:2) and arachidonic(C20:4) acids decline with fat deposition and therefore they can be considered as indicators of fatness.The aim of this research was to estimate the genetic variation for C18:2 and C20:4 in IMF and their genetic correlations with IMF and lean growth traits,with the objective to assess their potential as specific biomarkers of IMF.The analysis was conducted using a full-pedigreed Duroc resource line with 91,448 records of body weight and backfat thickness(BT) at 180 days of age and 1371 records of fatty acid composition in the muscle gluteus medius.Results: The heritability estimates for C18:2 and C20:4 in IMF,whether expressed in absolute(mg/g of muscle) or in relative(mg/g of fatty acid) terms,as well as for their ratio(C20:4/C18:2),were high(> 0.40),revealing that the C18:2 to C20:4 pathway is subjected to substantial genetic influence.Litter effects were not negligible,with values ranging from8% to 15% of the phenotypic variance.The genetic correlations of C18:2 and C20:4 with IMF and BT were negative(-0.75 to-0.66,for IMF,and-0.64 to-0.36,for BT),if expressed in relative values,but almost null(-0.04 to 0.07),if expressed in absolute values,except for C18:2 with IMF,which was highly positive(0.88).The ratio of C20:4 to C18:2 also displayed a stronger genetic correlation with IMF(-0.59) than with BT(-0.10).Conclusions: The amount of C18:2 in muscle can be used as an IMF-specific biomarker.Selection for the absolute amount of C18:2 is expected to deliver a similar response outcome as selection for IMF at restrained BT.Further genetic analysis of the C18:2 metabolic pathway may provide new insights into differential fat deposition among adipose tissues and on candidate genes for molecular markers targeting specifically for one of them. | Sofia Gol Rayner Gonzalez-Prendes Lluis Bosch Marc Tor Josep Reixach Ramona N.Pena Joan Estany | 2019 | Journal of Animal Science and Biotechnology2019，10，3： | 3 |
| 2 | Genetic parameters for egg number, egg weight, and eggshell color in the three Catalan poultry breeds 显示文摘 | Francesch A Estany J Alfonso L | 1997 | Poult Sci1997，76，12： | 1 |
| 3 | High prevalence of and pro- gression to low bone mineral density in HIV-infeeted patients: a longitudinal cohort study 显示文摘 | Bonjoch A Figueras M Estany C | 2010 | Aids2010，24，18： | 1 |
| 4 | Comparison of fatty acid profiles of edible meat, adipose tissues and muscles be- tween cocks and capons 显示文摘 | Tor M Estany J Francesch A | 2005 | Animal Research2005，54，5： | 1 |
| 5 | Combination therapy with rituximab and intravenous or oral fludarabine in the frostline, systemic treatment of patients with extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type显示文摘 | Salar A Domingo-Domenech E Estany C | 2009 | Cancer2009，115，22： | 1 |
| 6 | Predictive control strategy for DC/AC converters based on direct power control显示文摘 | Sergio A L Miguel A R V Estanis O | 2007 | IEEE Trans on Industrial Electronics2007，54，3： | 1 |
| 7 | Combination therapy with rituximab and intravenous or oral fludarabine in the first-line,systemic treatment of patients with extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type显示文摘 | Salar A Domingo-Domenech E Estany C | | 0，，22： | 1 |
| 8 | High prevalence of and progression to low bone mineral density in HIV infected patients: a longitudinal cohort study显示文摘 | Bonjoch A Figueras M Estany C | 2010 | AIDS2010，24，18： | 1 |
| 9 | Estimation of genetic parameters for litter size in Danish Landrace and Yorkshire pigs显示文摘 | ESTANY J SORENSEN D | 1995 | Anim Sci1995，60，2： | 1 |
| 10 | Combination therapy with rituximab and intravenous or oral fludarabine in the first-line,systemic treatment of patients with extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type显示文摘 | Salar A Domingo-Domenech E Estany C | 2009 | Cancer2009，115，22： | 1 |
| 11 | Combination therapy with rituximab and intravenous or oral fludarabine in the first-line,systemic treatment of patients with extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type显示文摘 | Salar A Domingo-Domenech E Estany C | 2013 | Cancer2013，115，： | 1 |
| 12 | Risk assessment of PSE condition due to pre-slaughter conditions and RYR1 gene in pigs显示文摘 | Guàrdia M D Estany J Balasch S | 2004 | Meat Science2004，67，3： | 1 |
| 13 | Risk assessment of DFD meat due to pre-slaughter conditions in pigs显示文摘 | GU-RDIA M D ESTANY J BALASCH S | 2005 | Meat Science2005，70，4： | 1 |
| 14 | A functional variant in thestearoyl-CoA desaturase gene promoter enhances fatty acid de-saturation in pork显示文摘 | Estany J Ros-Freixedes R’Tor al | 2014 | PLoS One2014，，86： | 1 |
| 15 | Risk assessment of PSE condition due to pre-slaughter conditions and RYR1 gene in pigs显示文摘 | GUARDIA M D ESTANY J BALASH S | 2004 | Meat Science2004，67，3： | 1 |
| 16 | Isolation of tissue-type plasminogen activator, cathepsin H, and non-specific cross-reacting antigen from SK-PC-1 pancreas cancer cells using subtractive hybridization显示文摘 | Rosanna Paciucci Georgina Berrozpe Montserrat Torà Estanis Navarro Antonio García de Herreros Francisco X. Real | 1996 | FEBS Letters1996，，1： | 1 |
| 17 | Genetic parameters for egg number, egg weight, and eggshell color in the catalan poultry breeds显示文摘 | Francesch A Estany J Alfonso L | 1997 | Poult Sci1997，76，12： | 1 |
| 18 | Risk assessment of PSE condition due to pre-slaughter conditions and RYRlgene in pigs显示文摘 | Gucirdia M D Estany J Balasch S | 2004 | Meat Science2004，67，： | 1 |
| 19 | Combined treatment with anti-CD20 (rituximab) and CHOP in relapsed advanced-stage follicular lymphomas 显示文摘 | Domingo-Domenech E Gonzalez-Barca E Estany C | 2002 | Haematologica2002，87，11： | 1 |
| 20 | Risk assessment of PSE condition due to pre-slaughter conditions and RYRlgene in pigs显示文摘 | Guardia M D Estany J Balasch S0 | 2004 | Meat Science2004，67，： | 1 |
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