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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Prediction of tensile strength of friction stir welded 6061 Al plates显示文摘The present paper investigates the prediction of tensile strength after friction stir welding(FSW)using artificial neural network(ANN)in the MATLAB program.The experimental results are used to develop the mathematical model.The combined influence of welding speed,rotation speed,and axial force on the tensile strength of 6061 Al plates is simulated.Results of the tensile test are used to train and test the ANN model.A multi-layer solution is developed using the ANN model to predict tensile strength.Back propagation(BP)method is initially trained using 80%of the experimental data,then,testing is performed with the rest of the data.Results indicate that predicted values are close to the corresponding measured values. | Farghaly Ahmed A El-Nikhaily Ahmed E Essa A R S | 2019 | China Welding2019，28，3： | 4 |
| 3 | A new approach for the recovery of precious metals from solution and from leachates derived from electronic scrap 显示文摘 | Maeaskie L E Creamer N J Essa A M M Brown N L | 2007 | Biotechnology and Bioengineering2007，96，4： | 1 |
| 4 | Solar drying characteris-tics of strawberry显示文摘 | Behagya A E Gamea G R Essa A H A | 2007 | Journal of Food Engi- neering2007，78，2： | 1 |
| 5 | A new approach for the reeovery of preeious metals from solution and from leachates derived from electronic serap显示文摘 | Macaskie L E Creamer N J Essa A M M | | 0，，： | 1 |
| 6 | A New Approach for the Recovery, of Precious Metals from Solution and fromLeach ates Derived from Electronic Scrap 显示文摘 | Macaskie L E Creamer N J Essa A M M | 2006 | Biotechnology and Bio-engineering2006，96，4： | 1 |
| 7 | Solar drying characteristics of strawberry显示文摘 | BELTAGYA A E GAMEA G R ESSA A H A | 2007 | Journal of Food Engineering2007，78，2： | 1 |
| 8 | New least-square algorithm for model parameters estimation using self- potential anomalies显示文摘 | Abdelrahman E M Essa K S Abo-Ezz E R | 2008 | Computers & Geosciences2008，34，： | 1 |
| 9 | A new approach for the recovery of precious metals from solution and from leachates derived from electronic scrap显示文摘 | Macaskie L E Creamer N J Essa A M | 2006 | Biotechnology and Bioengineering2006，96，4： | 1 |
| 10 | Shape and depth determinations from second moving average residual self-potential anomalies显示文摘 | Abdelrahman E M El-Araby T M Essa K S | 2009 | Journal of Geophysics and Engineering2009，，6： | 1 |
| 11 | Electroporation and ultradeformable liposomes, human skin barrier repair by phospholipid 显示文摘 | ESSA E A BONNER M C BARRY B W | 2003 | J Controlled Release2003，92，12： | 1 |
| 12 | Electrically assisted skin delivery of liposomal estradiol, phospholipid as damage retardant 显示文摘 | ESSA E A BONNER M C BARRY B W | 2004 | J Controlled Release2004，95，3： | 1 |
| 13 | A new approach for the recovery' of precious metals from solution and from leachates de- rived from electronic scrap显示文摘 | Macaskie L E Creamer N J Essa A M M | 2007 | Biotechnology and Bioengineering2007，96，4： | 1 |
| 14 | Cardiovascular magnetic resonance in wet beriberi 显示文摘 | Essa E Velez M R Smith S | 2011 | J Cardiovasc Magn Reson2011，13，1： | 1 |
| 15 | A new approach for the recovery of precious metals from solution and from leachates derived from electronic scrap 显示文摘 | Macaskie L E Creamer N J Essa A M M | 2007 | Biotechnology and bioengineering2007，96，4： | 1 |
| 16 | A new approach for the recovery of precious metals from solution and from leachates derived from electronic scrap 显示文摘 | MACASKIE L E CREAMER N J ESSA A M | 2006 | Biotechnology and Bioengineering2006，96，4： | 1 |
| 17 | A new approach for the recovery of precious metals from solution and from leachatederived from electronic scrap显示文摘 | Macaskie L E Creamer N J Essa A M M | | 0，，04： | 1 |
| 18 | Cardiovascular magnetic resonance in wet beriberi 显示文摘 | Essa E Michael R V S akima S | 2011 | Journal of Cardiovascular Magnetic Resonance2011，，13： | 1 |
| 19 | Liquisolid systems to improve the dissolution of furosemide显示文摘 | Akinlade B Elkordy A A Essa E A | 2010 | Sci Pharm2010，78，2： | 1 |
| 20 | Bioremoval capacity of three heavy metals by some microalgae species (Egyptian isolates) 显示文摘 | Shanab S Essa A Shalaby E | 2012 | Plant Signal Behavior2012，7，3： | 1 |
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