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48篇 您的检索式:作者名="Erster"
    题名 作者 年代 出处 被引量
1p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity显示文摘p53 的 apoptotic 节目由抄写依赖者和抄写无关的小径组成。在后者,在 mitochondrial p53 和 anti-apoptotic 和 mitochondrial 渗透管理者的 Bcl2 家庭的 pro-apoptotic 成员之间的物理相互作用是中央的。用有定义缺乏的 isogenic 房间系统,我们详细描绘 mitochondrial p53 怎么贡献 mitochondrial permeabilization,到什么程度,它的行动依靠另外的关键 Bcl2 家庭成员并且定义它的版本活动。我们证明 mitochondrial p53 在由严重地破坏外部、内部的 mitochondrial 膜正直导致可溶、不可溶解的 apoptogenic 因素的版本是高度有效的。这个行动与 Bax, Bak 和 VDAC 和在 p53 和 cyclophilin D 之间的导致压力的内长的建筑群的形成的野类型的导致 p53 的 oligomerization 被联系,通常在内部膜定位了。导出肿瘤的 p53 异种在激活 Bax/Bak 类脂化合物毛孔是缺乏的。这些行动独立于美洲狮和 Bax。重要地,后者把 mitochondrial 与 cytosolic p53 死亡小径区分开来。Sonja Wolff Susan Erster Gustavo Palacios Ute M Moll 2008Cell Research2008,18,7:9
2p53 has a direct apoptogenic role at the mitochondria显示文摘Mihara M Erster S Zaika A 2003Mol Cell2003,11,3:1
3p53 has a direct apoptogenic role at the mitochondria显示文摘Mihara M Erster S Zaika A 2003Mol Cell2003,11,3:1
4Polymerase chain reaction analysis of fragile X mutations显示文摘Erster SH Brown WT Goonewardena P 1992Hum Genet1992,90,12:1
5p53 has a direct apoptogenic role at the mitochondria显示文摘Mihara M Erster S Zaika A 2003Mol Cell2003,11,3:1
6p53 has a direct apoptogenic role at the mitochondria显示文摘Mihara M Erster S Zaika A 2003Mol Cell2003,3,:1
7Monoubiquityla- tion promotes mitochondrial p53 translocation 显示文摘Marchenko ND Wolff S Erster S 2007EMBO J2007,26,4:1
8Polymerase chain reaction analysis of fragile X mutation显示文摘Erster SH Brown WT Goonewardena P 1992Hum gene1992,90,:1
9P53 has a direct apoptogenic role at the mitochondria显示文摘Mihara M Erster S Zaika A 2003Mol Cell2003,11,:1
10p53 has a direct apoptogenic role at the mitochondria显示文摘Mihara M Erster S Zaika A 0,,:1
11P53 has a direct apoptogenic role at the mitochondria显示文摘Mihara M Erster S Zaika A 2003Mol Cell2003,11,3:1
12Delta P73,adominant negative inhibitor of wide type P53 and TAP73, is upregulated in human tumors显示文摘Zaika AI Slade N Erster SH 2002J Exp Med2002,196,6:1
13Np73, A dominant-negative inhibitor of wild-type p53 and TAp73 is up-regulated in human tumors显示文摘ZAIKA AI SLADE N ERSTER SH 2002J Exp Med2002,196,6:1
14P53, P^53 and P^73-solos, alliances and feuds among family members显示文摘Moll UM Erster S Zaika A 2001Biochem Biophys Acta2001,1552,:1
15p53 has a direct apoptogenic role at the mitoehondria 显示文摘MIHRA M ERSTER S ZAIKA A 2003Mol Cell2003,11,:1
16DeltaNp73,a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors显示文摘Zaika AI Slade N Erster SH 2002J Exp Med2002,196,6:1
17A modified inverse PCR procedure for insertion, deletion, or replacement of a DNA fragment in a target sequence and its application in the ligand interaction scan method for generation of ligand-regulated proteins显示文摘Erster O Liscovitch M 2010Methods in Molecular Biology2010,,634:1
18WT p53, but not tumor-derived mutants, bind to Bel2 via the DNA binding domain and induce mitoehondrial permeabilization 显示文摘Tomita Y Marchenko N Erster S 2006J Biol Chem2006,281,13:1
19p53 has a direct apoptogenic role at the mitochondria显示文摘Mihara M Erster S Zaika A 2003Mol Cell2003,11,3:1
20p53,p63 and p73- solos, alliances andfeuds among family members显示文摘Moll UM Erster S Zaika A 2001Biochem Biophys Acta2001,1552,:1
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