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98篇 您的检索式：作者名="Ermann"

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	题名	作者	年代	出处	被引量
1	Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts显示文摘Multiple regulatory mechanisms control osteoblast differentiation and function to ensure unperturbed skeletal formation and remodeling. In this study we identify histone lysine-specific demethylase 1(LSD1/KDM1 A) as a key epigenetic regulator of osteoblast differentiation. Knockdown of LSD1 promoted osteoblast differentiation of human mesenchymal stem cells(hMSCs)in vitro and mice lacking LSD1 in mesenchymal cells displayed increased bone mass secondary to accelerated osteoblast differentiation. Mechanistic in vitro studies revealed that LSD1 epigenetically regulates the expression of WNT7 B and BMP2. LSD1 deficiency resulted in increased BMP2 and WNT7 B expression in osteoblasts and enhanced bone formation, while downregulation of WNT7 B-and BMP2-related signaling using genetic mouse model or small-molecule inhibitors attenuated bone phenotype in vivo. Furthermore, the LSD1 inhibitor tranylcypromine(TCP) could increase bone mass in mice. These data identify LSD1 as a novel regulator of osteoblast activity and suggest LSD1 inhibition as a potential therapeutic target for treatment of osteoporosis.	Jun Sun Joerg Ermann Ningning Niu Guang Yan Yang Yang Yujiang Shi Weiguo Zou	2018	Bone Research2018，6，3：	5
2	Macropores and water flow in soils 显示文摘	I Beven K C ermann P	1982	Water Resources1982，18，5：	1
3	Autoimmune diseases:genes,bugs and failed regulation显示文摘	ERMANN J FATHMAN CG	2001	Nat Immunol2001，9，：	1
4	CD4CD25 cells facilitate the induction of T cell anergy显示文摘	Ermann J Szanya V Ford GS	2001	J Immunol2001，167，8：	1
5	Vitamin D status and mortality risk in CKD: a meta-analysis of prospective studies 显示文摘	PILZ S IODICE S ZITI'ERMANN A	2011	Am J Kidney Dis2011，58，3：	1
6	Donor-type CD4+CD25+ regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation显示文摘	Hoffinann P Ermann J Edinger M		0，，03：	1
7	Donor-type CD4^+ CD25^+ regulatory T cells suppress lethal acute graftversus-host disease after allogeneic bone marrow transplantation 显示文摘	Hoffmann P Ermann J Edinger M	2002	J Exp Med2002，196，6：	1
8	Sun, vitamin D, and cardiovas- cular disease显示文摘	ZIT'I'ERMANN A GUMMERT J F	2010	J Photobio B2010，101，2：	1
9	CD4 (+) CD25 (+) T cells facilitate the induction of T cell anergy显示文摘	Ermann J Szanya V Ford GS	2001	J Immunol2001，167，8：	1
10	Donor - type CD4^+ CD25^+ regulatory T cells suppress lethal acute graft - versus - host disease after allogeneic bone marrow transplantation 显示文摘	Petra Hoffmann Joerg Ermann Matthlas Edinger	2002	The Journal of Experimental Medicine2002，196，：	1
11	CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft- versus-host disease after bone marrow transplantation 显示文摘	Edinger M Hoffmann P Ermann J	2003	Nat Med2003，9，9：	1
12	Energy-adjustedab initio pseudopotentials for the second and third row transition elements显示文摘	D. Andrae U. H?u?ermann M. Dolg H. Stoll H. Preu?	1990	Theoretica Chimica Acta1990，，2：	1
13	Dermal substitution with Matridenn in bums on the dorsurn of the hand显示文摘	Ryssel H C ermann G Kloeters O	2010	Bums2010，36，8：	1
14	CD4^+ CD25^+ T Ceils facilitate the induction of T Cell anergy 显示文摘	Ermann J Szanya V Ford G S	2001	J Immunol2001，167，：	1
15	Energy- adjusted ab Initio Pseudo Potentials for the Second and Tthird Row Transition Ele- ments 显示文摘	Andrae D Haulβermann U Dolg M	1990	Theor Chim Acta1990，77，：	1
16	Protein microarrays for multiplex analysis is of signal transduction pathways 显示文摘	Chan SM Ermann J Su L	2004	Nat medicine2004，10，12：	1
17	Properties and ap- plications of gadolinium oxysulfide based ceramic scintil- lators 显示文摘	Rossner W Ostertag M J ermann F	2005	Electrochemical Society Proceedings2005，98，24：	1
18	Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury:a randomized control ed trial显示文摘	Wright D W Kel ermann A L Hertzberg V S		0，，：	1
19	After GWAS: mice to the rescue?显示文摘	Joerg Ermann Laurie H Glimcher	2012	Current Opinion in Immunology2012，，：	1
20	Donor - type CD4 + CD25 + regulatory T cells suppress lethal acute graft - versus - host disease after allogeneic bone marrow transplantation 显示文摘	Hoffmann P Ermann J Edinger M	2002	J Exp Med2002，196，3：	1

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