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| 1 | New multi protein patterns differentiate liver fibrosis stages and hepatocellular carcinoma in chronic hepatitis C serum samples显示文摘瞄准:识别一多象用为肝纤维变性(F1-F2 ) 的察觉和区别的提高表面的激光 desorption/ionisation time-of-flight 团 spectrometry (SELDI-TOF-MS ) 的单个蛋白质标记一样的浆液蛋白质模式,在有长期的丙肝病毒(HCV ) 的病人的肝肝硬化(F4 ) andhepatocellular 癌(HCC ) 。方法:有 F1/F2 纤维变性的 39 个病人,的 Serumsamples 有 F4 纤维变性的 44 个病人,有我们重新申请到 CM10 数组并且分析了使用 SELDI-TOF ProteinChip 系统的 HCC 的 34 个病人(PBS-IIc;CiphergenBiosystems ) 在阴离子交换分别以后。所有病人 andhistologically 有长期的丙肝证实的纤维变性 stage/HCC。数据被 multivariatestatistical 技术和人工的神经网络为蛋白质模式分析。结果:4 肽 / 蛋白质 multimarkerpanel (7486, 12843, 44293 和 53598 Da ) 正确地在训练样品(AUROC0.943 ) 的 HCV 肝硬化对 HCV-HCC 的二方法比较与 100% 的敏感和 85% 的特性识别了 HCC。为 HCC 的鉴定的敏感和特性为随机的测试样品是 68% 和 80% 。肝脏硬化症的病人能被歧视有多使用 5peptide/protein 的 F1 或 F2 纤维变性的病人标记模式( 2873 , 6646 , 7775 , 10525 和 67867 Da )与100%和在训练样品( AUROC 0.976 )的85%的敏感和敏感和特性of80%的特性并且67%为随机的测试样品。有 APRI 分数 andalfa-fetopotein (法新社) 的简历标记分类器的联合改进了诊断表演。为肝纤维变性的 6646 Da 标记蛋白质作为 apolipoprotein C-I 被识别。结论:与蛋白质模式分析相结合的 SELDI-TOF-MS 技术与长期的丙肝在病人为肝肝硬化 andhepatocellular 癌的鉴定似乎是一条珍贵途径。最可能,不同浆液标记的联合将帮助以后识别肝肝硬化和早阶段的 hepatocellularcarcinomas。 | Thomas Gbel Sonja Vorderwülbecke Katarzyna Hauck Holger Fey Dieter Hussinger Andreas Erhardt | 2006 | World Journal of Gastroenterology2006，12，47： | 21 |
| 2 | Transient elastography improves detection of liver cirrhosis compared to routine screening tests显示文摘AIM:To investigate the diagnostic significance oftransient elastography(TE) in a daily routine clinical setting in comparison to clinical signs,laboratory parameters and ultrasound.METHODS:TE,ultrasound,laboratory parameters and cutaneous liver signs were assessed in 291 consecutive patients with chronic liver disease of various aetiologies who underwent liver biopsy in daily routine.RESULTS:Sensitivity of TE for the detection of liver cirrhosis was 90.4%,compared to 80.1% for ultrasound,58.0% for platelet count and 45.1% for cutaneous liver signs(P < 0.0001 for comparisons with histology).AUROC for TE was 0.760(95%CI:0.694-0.825).Combination of TE with ultrasound increased sensitivity to 96.1% and AUROC to 0.825(95%CI:0.768-0.882).TE correlated with laboratory parameters of cirrhosis progression like albumin(r =-0.43),prothrombin time(r =-0.44),and bilirubin(r = 0.34; P < 0.001 for each).Particularly,in patients with Child Pugh score A or normal platelet count TE improved sensitivity for the detection of liver cirrhosis compared to ultrasound by 14.1%(P < 0.04) and 16.3%(P < 0.02),respectively.CONCLUSION:Transient elastography is superior to routine diagnostic tests allowing detection of liver cirrhosis in additional 10%-16% of patients with chronic liver disease that would have been missed by clinical examinations. | Thomas Gobel Janine Schadewaldt-Tümmers Lucas Greiner Christopher Poremba Dieter Haussinger Andreas Erhardt | 2015 | World Journal of Gastroenterology2015，21，3： | 8 |
| 3 | 儿童和青少年高血压的药物治疗:一项协作研究荟萃分析显示文摘儿童和青少年高血压对生活方式的改变若没有反应,需要药物治疗,但是没有足够的证据来推荐1类抗高血压药物。该文研究者对现存的儿科抗高血压药物治疗的随机临床试验进行荟萃分析。在总共554项潜在相关研究中,纳入了13项包括≥50例患者,随访≥4周的随机安慰剂对照临床试验。以治疗后收缩压和舒张压降低作为主要的观察指标。 | 刘青 叶鹏 Burrello J Erhardt EM Saint-Hilary G Veglio F Rabbia F Mulatero P Monticone S D'Ascenzo F | 2018 | 中华高血压杂志2018，26，8： | 4 |
| 4 | Could sport be part of pediatric obesity prevention and treatment? Expert conclusions from the 28th European Childhood Obesity Group Congress显示文摘The prevalence of pediatric obesity continues to increase worldwide,bringing with it various metabolic,functional,social,and psychological complications.1 Both the prevention and treatment of childhood obesity must be based on multidisciplinary approaches combining nutrition,physical activity(PA),and psychological support.2 As an essential element of these multicomponent strategies,regular physical activity has been acknowledged as having beneficial effects on children's and adolescents,body composition,physical fitness,and metabolic profile,as well as on their health-related quality of life,social and psychological health,and academic achievement.3,4 Given that only a relatively small proportion of children and adolescents meet the public health recommendations for PA,5 and given that weight loss exercise-based interventions suffer from a high attrition rate,there is a clear need for appropriate PAs. | Susanne Ring-Dimitriou Peter Krustrup Manuel J Coelho-E-Silva Jorge Mota Andera Seabra Carla Rego Artur Mazur Elpis Vlachopapadopoulou Margerita Caroli Marie-Laure Frelut Eva Erhardt Anders Forslund Ema Boyland Daniel Weghuber David Thivel | 2019 | Journal of Sport and Health Science2019，8，4： | 3 |
| 5 | Conserved Cytochrome P450 Evolved in Seed Plants Regulates Flower Maturation显示文摘植物染色体的全球检查识别越过 taxa 并且在强壮的净化的选择下面在低拷贝维持的基因,它是可能的有必要功能。基于这个基本原理,我们调查了在种子植物早出现了并且在强壮的否定选择下面演变的低副本的 CYP715 细胞色素 P450 基因家庭的功能。Arabidopsis CYP715A1 在开花期之上在花芽的 tapetum 并且在花药细丝显示出限制织物特定的表情。cyp715a1 插入线在花粉 intine 免职的花瓣开发,和短暂改变显示出一个强壮的缺点。比较表达式分析揭示了涉及花粉开发,房间墙生物的续生说,荷尔蒙动态平衡,和花的 sesquiterpene 的基因的 downregulated 表达式生合成,特别 TPS21 和调整象 MYB21, MYB24,和 MYC2 那样的花的开发的几关键基因。因此,花的 sesquiterpene 排放在 cyp715a1 异种被压制。另外,花荷尔蒙介绍显示了 gibberellinhomeostasis 和 jasmonic 酸衍生物的周转的强壮的骚乱的修正。花瓣生长被活跃赤霉素 GA 3 或 jasmonoyl 异白氨酸的功能的类似物部分恢复, coronatine。CYP715 看起来作为花成熟的一个关键管理者工作,同步花瓣扩大和不稳定的排放。是一个重要决定因素 offlower 昆虫相互作用因此被期望。 | Zhenhua Liu Benoit Boachon RaphaelLugan Raquel Tavares Mathieu Erhardt Jerome Mutterer Valerie Demais Stephanie Pateyron Veronique Brunaud Toshiyuki Ohnishi Ales Pencik Patrick Achard Fan Gong Peter Hedden Daniele Werck-Reichhart Hugues Renault | 2015 | Molecular Plant2015，8，12： | 3 |
| 6 | A Non-canonical Transferred DNA Insertion at the BRI1 Locus in Arabidopsis thaliana显示文摘Agrobacterium-mediated transformation is widely used in transgenic plant engineering and has been proven to be a powerful tool for insertional mutagenesis of the plant genome.The transferred DNA(T-DNA) from Agrobacterium is integrated into the plant genome through illegitimate recombination between the T-DNA and the plant DNA.Contrasting to the canonical insertion,here we report on a locus showing a complex mutation associated with T-DNA insertion at the BRI1 gene in Arabidopsis thaliana.We obtained a mutant line,named salade for its phenotype of dwarf stature and proliferating rosette.Molecular characterization of this mutant revealed that in addition to T-DNA a non-T-DNA-localized transposon from bacteria was inserted in the Arabidopsis genome and that a region of more than 11.5 kb of the Arabidopsis genome was deleted at the insertion site.The deleted region contains the brassinosteroid receptor gene BRI1 and the transcription factor gene WRKY13.Our finding reveals non-canonical T-DNA insertion,implicating horizontal gene transfer and cautioning the use of T-DNA as mutagen in transgenic research. | Zhong Zhao Yan Zhu Mathieu Erhardt Ying Ruan Wen-Hui Shen | 2009 | Journal of Integrative Plant Biology2009，51，4： | 2 |
| 7 | Caspase 3 activation is essential for neuroprotection in preconditioning 显示文摘 | McLaughlin B Hartneu KA Erhardt JA | 2003 | Proc Natl Acad Sci USA2003，100，： | 1 |
| 8 | Cigarette smoking:an undertreated risk factor for cardiovascular disease显示文摘 | Erhardt L | 2009 | Atherosclerosis2009，205，1： | 1 |
| 9 | HFE mutations and chronic hepatitis C:H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis显示文摘 | ERHARDT A MASCHNER-OLBERG A MELLENTHIN C | 2003 | J Hepatol2003，38，3： | 1 |
| 10 | Influence of different surface conditioning protocols on microtensile bond strength of self-adhesive resin cements to dentin显示文摘 | Pisani-Proenga J Erhardt MC Amaral R | 2011 | J Prosthet Dent2011，105，4： | 1 |
| 11 | SB239063, a novel p38 inhibitor, attenuates early neuronal injury following ischemia显示文摘 | Legos JJ Erhardt JA White RF | 2001 | Brain Res2001，892，： | 1 |
| 12 | Quantitative changes in interleukin proteins following focal stroke in the rat显示文摘 | LEGOS J J WHITMORE R G ERHARDT J A | 2000 | Neurosci Lett2000，282，3： | 1 |
| 13 | Pharmacologically elevated levels of endogenous kynurenic acid prevent nicotine-induced activation of nigral dopamine neurons显示文摘 | Erhardt S (o)berg H Engberg G | 2001 | Naunyn Schmiedebergs Arch Pharmacol2001，363，1： | 1 |
| 14 | Sampling Count Variables with specified Pearson Correlation-a Comparison between a naive and a C-vine Sampling Approach显示文摘 | Zenz Erhardt Claudia Czado | 2011 | Dependence modeling2011，，62： | 1 |
| 15 | Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation显示文摘 | ERHARDT S MELLONE B G BETTS C M | 2008 | J Cell Biol2008，183，： | 1 |
| 16 | Hepatitis C virus core protein induces cell proliferation and activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell line显示文摘 | Erhardt A Hassan M Heintges T | 2002 | Virology2002，292，2： | 1 |
| 17 | Caspase 3 activation is essential for neuroprotection in preconditioning显示文摘 | McLaughlin B Hartnett KA Erhardt JA | 2003 | Proc Natl Acad Sci USA2003，100，2： | 1 |
| 18 | Mutations of the core promoter and response to inferferon treatment in chronic replicative hepatitis B显示文摘 | ERHARDT A REINEKE U BONDIN D | 2000 | Hepatology2000，31，： | 1 |
| 19 | Cloning and molecular characterization of human high affinity antibody fragments against hepatitis C virus NS3 helicase 显示文摘 | Tessmann K Erhardt A Haussinger D | 2002 | J Virol Methods2002，103，1： | 1 |
| 20 | Recent Research on Team and Organizational Diversity:Swot Analysis and Implications 显示文摘 | Jackson SE Joshi A Erhardt NL | 2003 | Journal of Management2003，29，6： | 1 |
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