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| 1 | Expression and functional analysis of the rice plasma-membrane intrinsic protein gene family显示文摘血浆膜内在的蛋白质(果仁) 是 aquaporins 的一个亚科越过膜启用水的快、控制的 translocation。在这研究,我们系统地从米饭识别了并且克隆十果仁基因。基于他们编码了的氨基酸序列的类似,这些米饭果仁基因被分类进二个组并且指定了为 OsPIP1-1 到 OsPIP1-3 和 OsPIP2-1 到在玉米跟随果仁基因的名称的 OsPIP2-7。量的 RT-PCR 分析识别了三根特定并且一叶特定的 OsPIP 基因。而且,响应盐,干旱和骆驼毛的织物处理的每 OsPIP 基因的表示侧面详细被检验。OsPIP1 (OsPIP1-1 ) 或在野类型的 Arabidopsis,腌,然而并非腌更高的集中(NaCl 的 150 公里) 的处理的显示出的提高的忍耐(NaCl 的 100 公里) 和干旱(甘露糖醇的 200 公里) 的 OsPIP2 (OsPIP2-2 ) 过去表示的转基因的植物上的分析。总起来说,这些数据响应不同压力建议每 OsPIP 基因的一个不同角色,并且应该把新层加到米饭果仁基因的生理的功能的理解。 | Lei Guo Zi Yi Wang Hong Lin Wei Er Cui Jun Chen Meihua Liu Zhang Liang Chen Li Jia Qu Hongya Gu | 2006 | Cell Research2006，16，3： | 35 |
| 2 | Is nasopharyngeal cancer really a “Cantonese cancer”?显示文摘Nasopharyngeal cancer(NPC) is endemic in Southern China,with Guandong province and Hong Kong reporting some of the highest incidences in the world.The journal Science has called it a 'Cantonese cancer'.We propose that in fact NPC is a cancer that originated in the Bai-Yue('proto-Tai-Kadai' or 'proto-Austronesian' or 'proto-Zhuang') peoples and was transmitted to the Han Chinese in southern China through intermarriage.However,the work by John Ho raised the profile of NPC,and because of the high incidence of NPC in Hong Kong and Guangzhou,NPC became known as a Cantonese cancer.We searched historical articles,articles cited in PubMed,Google,monographs,books and Internet articles relating to genetics of the peoples with high populations of NPC.The migration history of these various peoples was extensively researched,and where possible,their genetic fingerprint identified to corroborate with historical accounts.Genetic and anthropological evidence suggest there are a lot of similarities between the Bai-Yue and the aboriginal peoples of Borneo and Northeast India;between Inuit of Greenland,Austronesian Mayalo-Polynesians of Southeast Asia and Polynesians of Oceania,suggesting some common ancestry.Genetic studies also suggest the present Cantonese,Minnans and Hakkas are probably an admixture of northern Han and southern Bai-Yue.All these populations have a high incidence of NPC.Very early contact between southern Chinese and peoples of East Africa and Arabia can also account for the intermediate incidence of NPC in these regions. | Joseph Tien Seng Wee Tam Cam Ha Susan Li Er Loong Chao-Nan Qian | 2010 | Chinese Journal of Cancer2010，29，5： | 37 |
| 3 | Intranasal recombinant human erythropoietin protects rats against focal cerebral ischemia显示文摘 | Yue - Ping Yu Qiu - Qin Xu Qi Zhang Wei - Ping Zhang Li - Hui Zhang Er - Qing Wei | 2005 | 中国药理通讯2005，22，4： | 20 |
| 4 | Changes in Temporal Concentration Property of Summer Precipitation in China during 1961–2010 Based on a New Index显示文摘Based on the property of entropy,a new index Q was defined to measure the temporal concentration property of summertime daily rainfall in China,based on daily precipitation data collected at 553 observation stations in China during 1961–2010.Furthermore,changes in the temporal concentration property of summer precipitation in China were investigated.The results indicate that the regions with larger Q values were located in most parts of Northwest China and the north of the Yellow River,where daily precipitation tended to become temporally concentrated during the study period.On the contrary,smaller Q values were found in eastern Tibetan Plateau,southeastern Northwest China,and most parts of Southwest and South China.The most obvious increasing trend of Q index was found in South China and most parts of Southwest China,where precipitation showed a temporal concentration trend.However,a decreasing trend of Q index was found in Northwest China,the Tibetan Plateau,and the north of the Huaihe River.Variations of the Q index and the summer rainfall total during 1961–2010 in China both exhibited an increasing trend,implying larger temporal variability in rainfall attributes.It is illustrated that the summer precipitation in general became more temporally concentrated with more intense rainfall events and wetter days. | Hui LI Panmao ZHAI Er LU Wei ZHAO Yang CHEN Huan WANG | 2017 | Journal of Meteorological Research2017，31，2： | 9 |
| 5 | THERMODYNAMIC ANALYSIS OF Mo-La_2O_3 THERMIONIC CATHODE WIRE显示文摘THERMODYNAMICANALYSISOFMo-La_2O_3THERMIONICCATHODEWIRE￥ZhouMeiling;WangJinshu;ZhangJiuxing;NieZuoren;LiEr;ZuoTieyong(Departmen... | Zhou Meiling Wang Jinshu Zhang Jiuxing Nie Zuoren Li Er Zuo Tieyong(Department of Materials Science and Engineering,Beijing Polytechnic University,Beijing 100022) | 1996 | 中国有色金属学会会刊:英文版1996，6，4： | 9 |
| 6 | Meiofauna Distribution in Intertidal Sandy Beaches Along China Shoreline(18?–40?N)显示文摘In this study,the distribution pattern of meiofauna from nine sandy beaches at six latitudinal gradients along Chinese coast between 18 and 40?N was studied on their meiofauna abundance to examine the effect of latitudinal gradients.In general,meiofauna abundance was lower in four subtropical beaches in Xiamen(24?N) and Zhoushan(29?N) than that in other beaches.Meiofauna abundance differed little between tropical and temperate beaches.The taxonomic structure of meiofauna showed a dominance of nematode in colder area.The relative composition of turbellarians and polychaetes increased in warmer area.In addition to latitudinal gradient,salinity,oxygenation,sediment grain size affect also the meiofauna latitudinal distribution.As for horizontal distribution,the highest meiofauna abundance was found in low tidal zone at tropical beaches,and in middle tidal zone at temperate beaches.The horizontal distribution of meiofauna was controlled by both physical and biotic factors including feeding and anthropogenic activities.Although meiofauna abundance exhibited a horizontal difference,the composition of meiofaunal main taxa was unanimous horizontally at all beaches at the same sampling latitude. | HUA Er ZHANG Zhinan ZHOU Hong MU Fanghong LI Jia ZHANG Ting CONG Bingqing LIU Xiaoshou | 2016 | Journal of Ocean University of China2016，15，1： | 7 |
| 7 | Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance显示文摘有非小的房间肺癌症(NSCLC ) 的最对待 gefitinib 的病人将最后开发抵抗。从 LC Hemsl 的 Lysimachia capillipes (LC ) capilliposide 摘录。在 vitro 并且在 vivo 反癌症效果出现。在这研究,我们调查了在有 gefitinib 的联合的 LC capilliposide 是否能克服 NSCLC 房间的抵抗到 gefitinib 并且识别包含的发信号的小径。有 LC capilliposide 的治疗独自禁止了 NSCLC 房间线(PC-9, H460, H1975, H1299 和 PC-9-GR ) 的一块面板的生长对有在 g/mL 的范围的 IC 50 价值的 gefitinib 敏感或抵抗。在 gefitinib 抵抗的 PC-9-GR 房间(它有一个 T790M EGFR 变化) , LC capilliposide (在 IC30, i.e.1.2 g/mL ) 显著地与它的 IC50 价值提高了 gefitinib 的禁止的效果从 6.80 | Shi-rong ZHANG Ya-si XU Er JIN Lu-cheng ZHU Bing XIA Xu-feng CH EN Fan-zhu LI Sheng-lin MA | 2017 | Acta Pharmacologica Sinica2017，38，1： | 7 |
| 8 | Challenges and strategies for next-generation bispecific antibody-based antitumor therapeutics显示文摘Bispecific antibodies(bsAbs)refer to a large family of molecules that recognize two different epitopes or antigens.Although a series of challenges,especially immunogenicity and chain mispairing issues,once hindered the development of bsAbs,they have been gradually overcome with the help of rapidly developing technologies in the past 5 decades.In the meantime,an increasing number of bsAb platforms have been designed to satisfy different clinical demands.Currently,numerous preclinical and clinical trials are underway,portraying a promising future for bsAb-based cancer treatment.Nevertheless,bsAb drugs still face enormous challenges in their application as cancer therapeutics,including tumor heterogeneity and mutational burden,intractable tumor microenvironment(TME),insufficient costimulatory signals to activate T cells,the necessity for continuous injection,fatal systemic side effects,and off-target toxicities to adjacent normal cells.Therefore,we provide several strategies as solutions to these issues,which comprise generating multispecific bsAbs,discovering neoantigens,combining bsAbs with other anticancer therapies,exploiting natural killer(NK)-cell-based bsAbs and producing bsAbs in situ.In this review,we mainly discuss previous and current challenges in bsAb development and underscore corresponding strategies,with a brief introduction of several typical bsAb formats. | Heliang Li Phei Er Saw Erwei Song | 2020 | Cellular & Molecular Immunology2020，17，5： | 6 |
| 9 | Grape Seed Procyanidin Extract Attenuate Sodium Fluoride-induced Oxidative Damage and Apoptosis in Rat Kidneys显示文摘Fluoride is widely distributed in nature,and it can lead to fluorosis if intake is excessive.In addition to its established effects on the skeleton and teeth,fluoride can also exert toxic effects on the kidneys.Fluoride can induce abnormal renal function in humans and other animals[1-3],but the mechanisms through which fluoride exerts such effects remain obscure. | WANG Er Hui YU Zeng Li PING Guan Fang ZHAI De Sheng | 2020 | Biomedical and Environmental Sciences2020，33，6： | 5 |
| 10 | Recombinant scorpion insectotoxin AaIT kills specifically insect cells but not human cellss显示文摘The nucleotide sequence deduced from the amino acid sequence of the scorpion insectotoxin AaIT was chemically synthesized and was expressed in Escherichia coli. The authenticity of this in vitro expressed peptide was confirmed by N-terminal peptide sequencing. Two groups of bioassays, artificial diet incorporation assay and contact insecticidal effect assay, were carried out separately to verify the toxicity of this recombinant toxin. At the end of a 24 h experimental period, more than 60% of the testing diamondback moth (Plutella xylostella) larvae were killed in both groups with LCs0 value of 18.4 uM and 0.70 μM respectively. Cytotoxicity assay using cultured Sf9 insect cells and MCF-7 human cells demonstrated that the toxin AaIT had specific toxicity against insect cells but not human cells. Only 0.13 μM recombinant toxin was needed to kill 50% of cultured insect cells while as much as 1.3μM toxin had absolutely no effect on human cells. Insect cells produced obvious intrusions from their plasma membrane before broken up. We infer that toxin AaIT bind to a putative sodium channel in these insect cells and open the channel persistently, which would result in Na+ influx and finally cause destruction of insect cells. | SHENG JIAN JI, FENG LIU, ER Qiu LI, Yu XIAN ZHUThe National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China | 2002 | Cell Research2002，12，2： | 4 |
| 11 | Human Immunodeficiency Virus Infection-Associated Mortality during Pulmonary Tuberculosis Treatment in Six Provinces of China显示文摘Objective To investigate the risk factors attributable to tuberculosis-related deaths in areas with human immunodeficiency virus(HIV) infection epidemics. Methods A prospective cohort study of newly registered patients in tuberculosis(TB) dispensaries in six representative Chinese provinces was conducted from September 1, 2009 to August 31, 2011. Risk factors for TB-associated death were identified through logistic regression analysis. Results Of 19,103 newly registered pulmonary TB patients, 925(4.8%) were found to be HIV-positive. Miliary TB and acid-fast bacillus smear-negative TB were more common among these patients. Out of a total of 322(1.7%) deaths that occurred during TB treatment, 85(26%) of the patients were co-infected with HIV. Multivariate analysis revealed that HIV infection was the strongest predictor of death [adjusted odds ratio(aO R) 7.86]. Other significant mortality risk factors included presentation with miliary TB(aO R 4.10; 95% confidence interval: 2.14-7.88), ≥35 years of age(aO R 3.04), non-Han ethnicity(aO R 1.67), and farming as an occupation(aO R 1.59). For patients with TB/HIV co-infection, miliary TB was the strongest risk factor for death(aO R 5.48). A low CD4 count(≤ 200 cells/μL)(aO R 3.27) at the time of TB treatment initiation and a lack of antiretroviral therapy(ART) administration(aO R 3.78) were also correlated with an increased risk of death. Conclusion Infection with HIV was independently associated with increased mortality during TB treatment. Offering HIV testing at the time of diagnosis with TB, early TB diagnosis among HIV/acquired immunodeficiency syndrome patients, and the timely provision of ART were identified as the key approaches that could reduce the number of HIV-associated TB deaths. | LAI Yu Ji LIU Er Yong WANG Li Ming Jamie P MORANO WANG Ning Kaveh KHOSHNOOD ZHOU Lin CHENG Shi Ming | 2015 | Biomedical and Environmental Sciences2015，28，6： | 4 |
| 12 | Designing Advanced Aqueous Zinc-Ion Batteries:Principles,Strategies,and Perspectives显示文摘Aqueous zinc-ion batteries(AZIBs)are an appealing battery system due to their low cost,intrinsic safety,and environmental-friendliness,while their application is plagued by the obstacles from the cathode,electrolyte,and zinc anode.Summarizing the design principles and strategies toward the optimization of cathode,electrolyte,and zinc anode is crucial for the development of AZIBs.Herein,we present a comprehensive analysis of the design principles and promising strategies toward the improvement of AZIBs.Firstly,the various reaction mechanisms are summarized and the existing issues associated with the cathode,electrolyte,and zinc anode are discussed to guide the rational design of AZIBs.Subsequently,we provide an in-depth and comprehensive discussion on the design principles and strategies for the electrodes/electrolyte/separator optimization,and analyze the advantages and disadvantages of various strategies.Importantly,the design principles and strategies of the newly appeared conversion-type AZIBs,such as Zn-S battery and Zn-Se battery,are also discussed and analyzed.The effect of design strategies on the electrochemical performance and the relationship between the current issues and strategies are also unveiled in detail.Finally,some research trends and perspectives are provided for designing better AZIBs. | Yan Li Zhouhao Wang Yi Cai Mei Er Pam Yingkui Yang Daohong Zhang Ye Wang Shaozhuan Huang | 2022 | Energy & Environmental Materials2022，5，3： | 4 |
| 13 | Performance Comparison and Analysis of IP and MPLS Networks显示文摘With the increasing need for Quality of Service( QoS ),the traditional IP network is becoming less competitive. In order to give readers quantitative and convictive performance comparisons between IP and MPLS network,we choose Berkeleys NS 2 simulator [1] in our research on network throughput and end to end TCP behavior. Using NS 2 simulator,we analyze the performance of a network with MPLS Traffic Engineering( MPLS TE ).Specifically,the throughput and TCP end to end delay time under two different queuing algorithms are obtained and compared between the MPLS network and traditional IP network. We find that in the IP network using SFQ queuing algorithm will help traffic balance compared to the simple FIFO scheme,but it still can not utilize the available bandwidth,which in turn leads to the poor performance as in the FIFO case.With MPLS TE , the throughput will be higher and the end to end TCP delay time remains almost the same even in heavy load case.We notice that if flows are isolated partially,using SFQ scheme will have a comparable performance as the fully isolation case using FIFO scheme in a MPLS network,and that if flows are isolated fully for FIFO and SFQ schemes,both will have the same result.Finally,we conclude that a better queuing algorithm will help reduce the label space requirement. | LIU Er wu, CAO Ming cui, CHEN Chun han, LI Feng (State Key Laboratory of Laser Technology, Huazhong University of Science and Technology, Wuhan 430074, P.R.China) | 2001 | The Journal of China Universities of Posts and Telecommunications2001，8，2： | 3 |
| 14 | Petroleum Accumulation:from Continuous to Discontinuous显示文摘1 Introduction Petroleum accumulations from the Earth’s crust can be grouped into conventional and unconventional ones.The history of the world’s petroleum exploration is a history from the exploration of conventional accumulations to that of unconventional ones.Nevertheless,petroleum accumulation is actually a contrary process starting | ZHAO Jingzhou CAO Qing BAI Yubin ER Chuang LI Jun WU Weitao SHEN Wuxian | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 2 |
| 15 | A small functional intramolecular region of NodD was identified by mutation显示文摘在根瘤细菌属 leguminosarum bv。viciae,作为 LysR 类型 transcriptional 管理者(LTTR ) 的一个成员, NodD 施加自动调整并且面对 naringenin 激活另外的点头基因的抄写。LTTR 典型地由 N 终端 DNA 有约束力的领域和 C 终端组成规章的领域。在这研究,由系统的插入变化,在一些 NodD 的 12 氨基酸的一个区域作为功能的领域被识别。在这个区域的插入异种看起来获得组成地激活 nodA 基因的能力并且保留了他们的自动调整性质。这个识别区域被显示是通过用 Swiss-PDB 观众软件造的模型揭示了的 NodD 的绞链。报导作为 LysR 家庭的一个成员, NodD 被显示了包含影响它的性能的短 intramolecular 域是第一次。 | Bihe Hou Fengqing Li Xiao'er Yang Guofan Hong | 2009 | Acta Biochimica et Biophysica Sinica2009，41，10： | 2 |
| 16 | Hot Deformation Behavior of Low Carbon Steel during Compression at Elevated Temperature显示文摘Hot compression tests of low carbon steel were carried out on Gleeble-3500 system in the temperature range from 750 to 900 ℃ and in the strain rate range from 0.001 to 1.0 s-1, and the associated microstructural evolution was studied by observations with a metallographic microscope. The results show that the stress-strain curves exhibit a peak stress at critical strain, after which the fl ow stresses decrease monotonically until reaching high strains, showing a dynamic fl ow softening. The peak stress level decreases with increasing deformation temperature and decreasing strain rate, which can be represented by the Zener-Hollomon parameter Z in the hyperbolic sine equation. The fl ow stress increases with increasing strain rate and decreasing deforming temperature. The fl ow stress can be described by constitutive equation in hyperbolic sine function and can also be described by a Zener–Hollomon parameter Z. With increasing deformation temperature and decreasing strain rate, the grain size as well as the volume fraction of the recrystallized grains increase. The safe region for hot working of the alloy has been determined according to the processing map and microstructure at the true strain of 0.5, which is the deformation temperature of 840-940 ℃ and the strain rate of 0.001-1.0 s-1. | 刘和平 LIU Bin LI Dazhao SUN Hu'er SUN Feng'er JIN Xuejun ZHANG Yongtao | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，3： | 2 |
| 17 | The petroleum system:a new classification scheme based on reservoir qualities显示文摘A new classification of petroleum systems(PSs) based on reservoir qualities is proposed. We classify PSs into the following three basic types:(1) source-rock petroleum system(SPS);(2) tight-reservoir or tight petroleum system(TPS);and(3) conventional-reservoir or conventional petroleum system(CPS). The CPS is a PS in which hydrocarbons accumulate in conventional reservoirs, and all the essential elements and processes are significant and indispensable. Oil and gas accumulations are geographically discrete and therefore exist as discontinuous accumulations. The TPS is a PS where hydrocarbons accumulate in tight reservoirs and the source rock, reservoir, seal, migration, and trap are also indispensable,but the traps are mostly non-anticlinal and the accumulations are primarily quasi-continuous and secondarily discontinuous. The SPS is a PS where both hydrocarbon generation and accumulation occurred in source rocks and traps and migration are unnecessary or inconsequential; the hydrocarbon distribution is extensive and continuous and has no distinct boundaries. The aforementioned three PSs can be derived from a common hydrocarbon source kitchen and are closely linked in terms of their formation and distribution. Therefore, to maximize the exploration efficiency, a comprehensive study and different strategies are needed by considering the SPS, TPS, and CPS as parts of a greater whole. | Jing-Zhou Zhao Jun Li Wei-Tao Wu Qing Cao Yu-Bin Bai Chuang Er | 2019 | Petroleum Science2019，16，2： | 2 |
| 18 | Nematode Community Structure and Diversity Pattern in Sandy Beaches of Qingdao,China显示文摘We investigated the diversity and structure of free-living marine nematode communities at three sandy beaches representing typical intertidal environments of a temperate zone in Qingdao,Shandong Province,China.Average nematode abundance ranged from 1006 to 2170 ind.10 cm-2,and a total of 34 nematode genera were recorded,of which only 8 were common in all the studied beaches.Pielou's evenness and Shannon-Wiener diversity index were the lowest at the second beach where nematode abundance was the highest.The highest species diversity index coincided with the lowest nematode abundance at Shilaoren beach.Sediment median grain size,sorting coefficient,and chlorophyll-a content were essential for differentiation in nematode abundance and species diversity,whereas taxonomic diversity of nematode was homogeneous across the three beaches.In 0–20 cm sediment profile,nematode abundance declined abruptly with depth,whereas nematode diversity changed gently with obvious difference in 16–20 cm layer.Sediment granulometry and chlorophyll-a content were the two foremost factors which influenced the vertical distribution pattern of nematode generic diversity.Non-selective deposit feeders constituted the most dominant trophic group,followed by epistratum feeders.Bathylaimus(family:Tripyloididae) dominated at the second and Yangkou beach,while Theristus(family:Xyalidae) prevailed at Shilaoren beach.Omnivores and predators became important at Shilaoren beach because of the high proportion of Enoplolaimus.Even though,nematode community of the studied beaches did not differ significantly from each other. | HUA Er MU Fanghong ZHANG Zhinan YANG Shichao ZHANG Ting LI Jia | 2016 | Journal of Ocean University of China2016，15，1： | 2 |
| 19 | Extraction of coal-tar pitch using NMP/ILs mixed solvents显示文摘Coal-tar pitch(CP)is a promising carbon raw material for producing needle coke,carbon fiber etc.During processing,the H/C ratio,ash content,and quinoline insoluble(QI)in the CP are the key factors that influence the material preparation.In this study,NMP was selected to extract CP first;then[BMIM]Cl/NMP mixed solvent was used;and finally a series of ionic liquids(ILs)mixtures with NMP were developed for the extraction of CP to obtain the refined pitch.The extracts were analyzed via elemental analysis,TGA,FT-IR,and 13C-NMR.Results indicate that different NMP/IL mass ratios or different kinds of ILs have impact on the extraction yield.The relationship of the hydrogen to carbon(H/C)ratio changed with different solvents and QI extracts were obtained.Results showed that the H/C ratios changed little between NMP extracts and could be adjusted by changing the NMP/ILs mass ratio or using different ILs.The extracts are suitable for preparation mesophase pitch because of no ash content,low QI,and appropriate H/C ratios.As a result,NMP can be used to refine pitch.In addition,[BMIM]Cl is good mixed with NMP for CP extraction,because it can obtain a relatively high yield under the same extraction conditions. | HUANG Jin Cheng LI Chun Shan BAI Lu NIE Yi WANG Er Qiang HE Yu Jian ZHANG Suo Jiang | 2014 | Science China Chemistry2014，57，12： | 2 |
| 20 | Combination of a biopharmaceutic classification system and physiologically based pharmacokinetic models to predict absorption properties of baicalein in vitro and in vivo显示文摘Objective: To determine the in vitro and in vivo absorption properties of active ingredients of the Chinese medicine, baicalein, to enrich mechanistic understanding of oral drug absorption.Methods: The Biopharmaceutic Classification System(BCS) category was determined using equilibrium solubility, intrinsic dissolution rate, and intestinal permeability to evaluate intestinal absorption mechanisms of baicalein in rats in vitro. Physiologically based pharmacokinetic(PBPK) model commercial software GastroPlus~(TM) was used to predict oral absorption of baicalein in vivo.Results: Based on equilibrium solubility, intrinsic dissolution rate, and permeability values of main absorptive segments in the duodenum, jejunum, and ileum, baicalein was classified as a drug with low solubility and high permeability. Intestinal perfusion with venous sampling(IPVS) revealed that baicalein was extensively metabolized in the body, which corresponded to the low bioavailability predicted by the PBPK model. Further, the PBPK model predicted the key indicators of BCS, leading to reclassification as BCS-II. Predicted values of peak plasma concentration of the drug(C_(max)) and area under the curve(AUC)fell within two times of the error of the measured results, highlighting the superior prediction of absorption of baicalein in rats, beagles, and humans. The PBPK model supported in vitro and in vivo evidence and provided excellent prediction for this BCS class II drug.Conclusion: BCS and PBPK are complementary methods that enable comprehensive research of BCS parameters, intestinal absorption rate, metabolism, prediction of human absorption fraction and bioavailability, simulation of PK, and drug absorption in various intestinal segments across species. This combined approach may facilitate a more comprehensive and accurate analysis of the absorption characteristics of active ingredients of Chinese medicine from in vitro and in vivo perspectives. | Yang Liu Jing Sun Linying Zhong Yu Li A Na Er Tong Li Le Yang Ling Dong | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，3： | 2 |
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