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| 1 | The circulating non-coding RNA landscape for biomarker research: lessons and prospectsfrom cardiovascular diseases显示文摘人的染色体的弥漫的抄写为无数非编码的 RNA 分子(ncRNAs ) 的生产负责有规章的功能的他们的一些。在心血管的生物学的 ncRNAs 的枢轴的角色在最后十年被揭开了,从在心血管的开发和功能的 micro-RNAs 的参与的描述开始,并且作为心血管的疾病的 biomarkers 由传播 ncRNAs 的使用列在后面。人的非编码的 secretome 被几 RNA 种填写在身体液体传播并且能为诊断和结果预言被用作 biomarkers。在心血管的疾病,分泌了 ncRNAs 包括心肌的梗塞,心脏的失败,和 atrial 纤维性颤动被描述了为几个条件的 biomarkers。在传播之中, ncRNAs, micro-RNAs (miRNAs ) ,长 noncoding RNA (lncRNAs ) 和圆形的 RNA (circRNAs ) 在不同心血管的疾病作为 biomarkers 被建议了。与标准 biomarkers 比较, ncRNAs 的生物化学的性质为更好的稳定性和灵活存储提供样品,和增加的敏感和特性的条件。在这评论,我们把当前的趋势和 ncRNA secretome 部件的使用的未来前景描述为心血管的疾病的 biomarkers,包括与他们的分泌物机制和规章的行动联系的开的问题。 | Ewa STFPIEN Marina C COSTA Szczepan KURC Anna DROZDZ Nuno CORTEZ-DIAS Francisco J ENGUITA | 2018 | Acta Pharmacologica Sinica2018，39，7： | 14 |
| 2 | Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer显示文摘Objective:Long-term survivors(LS)of non-small cell lung cancer(NSCLC)without driver alterations,displaying an overall survival(OS)of more than 3 years,comprise around 10%of cases in several series treated with chemotherapy.There are classical prognosis factors for these cases[stage,Eastern Cooperative Oncology Group(ECOG),etc.],but more data are required in the literature.In this multi-center study,we focused on LS of advanced NSCLC with OS above 36 months to perform a clinical-pathological and molecular characterization.Methods:In the first step,we conducted a clinical-pathological characterization of the patients.Afterwards,we carried out a genetic analysis by comparing LS to a sample of short-term survivors(SS)(with an OS less than 9 months).We initially used whole-genome RNA-seq to identify differentiating profiles of LS and SS,and later confirmed these with reverse transcription-polymerase chain reaction(RT-PCR)for the rest of the samples.Results:A total of 94 patients were included,who were mainly men,former smokers,having adenocarcinoma(AC)-type NSCLC with an ECOG of 0-1.We obtained an initial differential transcriptome expression,displaying 5 over-and 33 under-expressed genes involved in different pathways:namely,the secretin receptor,surfactant protein,trefoil factor 1(T FF1),serpin,Ca-channels,and Tolllike receptor(TLRs)families.Finally,RT-PCR analysis of 40(20 LS/20 SS)samples confirmed that four genes(surfactant proteins and SFTP)were significantly down-regulated in SS compared to LS by using an analysis of covariance(ANCOVA)model:SFTPA1(P=0.023),SFTPA2(P=0.027),SFTPB{P=0.02),and SFT PC(P=0.047).Conclusions:We present a sequential genetic analysis of a sample of NSCLCLS with no driver alterations,obtaining a differential RNA-seq/RT-PCR profile showing an abnormal expression of SF genes. | Juan Moreno-Rubio Santiago Ponce Rosa Alvarez Maria Eugenia Olmedo Sandra Falagan Xabier Mielgo Fatima Navarro Patricia Cruz Luis Cabezon-Gutierrez Carlos Aguado Gonzalo Colmenarejo Marta Munoz-Fernandez de Leglaria Ana Belen Enguita Maria Cebollero Amparo Benito Isabel Alemany Carolina del Castillo Ricardo Ramos Ana Ramirez de Molina Enrique Casado Maria Sereno | 2020 | Cancer Biology & Medicine2020，17，2： | 4 |
| 3 | Is there a role for systemic targeted therapy after surgical treatment for metastases of renal cell carcinoma?显示文摘Metastatic renal cell carcinoma(m RCC) is a challenging disease. Despite the new targeted therapies, complete remissions occur only in 1%-3% of the cases, and the most effective first-line treatment drugs have reached a ceiling in overall survival(ranging from 9 to 49 mo). Metastasectomy remains to be the only curative option in most patients with m RCC. Prognostic nomograms have been recently published, so we have tools to classify patients in risk groups, allowing us to detect the cases with the higher risk of recurrence after metastasectomy. Although sparse, there is some evidence of effectiveness of neoadjuvant targeted therapy before metastasectomy; but with an increase in surgical complications due to the effects of these new drugs in tissue healing. We have aimed to answer the question: Is there a role for systemic targeted therapy after surgical treatment for metastases of renal cell carcinoma? We have made a search in Pubmed database. As far as we know, evidence is low and it's based in case reports and small series of patients treated with adjuvant drugs after neoadjuvant therapy plus metastasectomy in cases of partial response to initial systemic treatment. Despite the limitations and high risk of bias, promising results and cases with longterm survival with this approach have been described. Two ongoing clinical trials may answer the question that concerns us. | Adrian Husillos Alonso Manuel Carbonero García Carmen González Enguita | 2015 | World Journal of Nephrology2015，4，2： | 3 |
| 4 | MicroRNA Profiling in Plasma or Serum Using Quantitative RT-PCR显示文摘 | Costa MC Leita o AL Enguita FJ | 2014 | Methods Mol Biol2014，1182，： | 1 |
| 5 | Substrate and dioxygen binding to the endospore coat laccase from Bacillus subtilis 显示文摘 | ENGUITA F J MARCAL D MARTINS L O | 2004 | J Biol Chem2004，279，23： | 1 |
| 6 | Neuronal pentraxin 1 contributes to the neuronal damage evoked by amyloidbeta and is overexpressed in dystrophic neurites in Alzheimer's brain 显示文摘 | Abad MA Enguita M DeGregorio-Rocasolano N | 2006 | J Neurosci2006，26，12： | 1 |
| 7 | Hematuria of papillary or medullar origin: a difficult diagnosis entity 显示文摘 | Gonzalez Enguita C G6mez Mufioz J Martin Vivas C | 2008 | Arch Esp Urol2008，61，5： | 1 |
| 8 | Neuronal pentraxin 1 contributes to the neuronal damage evoked by amyloid-beta and is overexpressed in dystrophic neurites in Alzheimer's brain显示文摘 | Abad MA Enguita M DeGregorio-Rocasolano N | | 0，，49： | 1 |
| 9 | Crystal Structure of a Bacterial Endospore Coat Component 显示文摘 | Francisco J Enguita Ligia O M artins Adriano O H Enrique | 2003 | The Journal of Biological Chemistry2003，278，19： | 1 |
| 10 | Crystal structure of a bacterial endospore coat component--A laccase with enhanced thermostability properties显示文摘 | Enguita FJ Martins LO Henriques AO | 2003 | Journal of Biological Chemistry2003，278，19： | 1 |
| 11 | Crystal structure of a bacterial endospore coat component:a laccase with enhanced thennostability properties 显示文摘 | Enguita F J Martins L O Hennques A O | 2003 | J Biol Chem2003，278，19： | 1 |
| 12 | Apolipoprotein D expression in metastasic lymph nodes of brest cancer显示文摘 | Lamelas ML Vazquez J Enguita MI | 2000 | Int J Surg Investig2000，2，4： | 1 |
| 13 | A two-protein component 7u-cephem-methoxylase encoded by two genes of the cephamycin C cluster converts cephalosporin C to 7-methoxycephalosporin C显示文摘 | Coque J J R Enguita F J Marti N J F et ai | 1995 | J Bacteriol1995，177，8： | 1 |
| 14 | Inhibition of phosphatidylcholine synthesis is associated with excitotoxic cell death in cerebellar granule cell cultures 显示文摘 | Gasull T DeGregorio Rocasolano N Enguita M | 2002 | Amino Acids2002，23，13： | 1 |
| 15 | Semi-mechanistic description of the in-vitro antiproliferative effect of different antitumour agents 显示文摘 | Moreno D Troconiz IF Enguita M | 2008 | J Pharm Pharmaco12008，60，1： | 1 |
| 16 | Crystal structure of a bacterial endospore coat component a laccase with enhanced thermostability properties 显示文摘 | Enguita FJ Martins LO Henriques AO | 2003 | J Biol Chem2003，278，19： | 1 |
| 17 | Effect of exogenous lysine on the expression of early cephamycin C biosynthetic genes and antibiotic production in Nocardia lactamdurans MA4213 显示文摘 | Leit:o AL Enguita F J Martin JF | 2001 | Appl Microbiol Biotechnol2001，56，56： | 1 |
| 18 | Crystal structure of a bacterial endospore coat component显示文摘 | Enguita F J Martins F O Henrique A O | 2003 | The Journal of Biological Chemistry2003，278，19： | 1 |
| 19 | A guide for miRNA tar- get prediction and analysis using web-based applications显示文摘 | Leitao A L Costa M C Enguita F J | 2014 | Meth Mol Biol2014，1182，： | 1 |
| 20 | The new IASLC/ ATS/ERS lung adeuocarcinoma classification from a clinicalperspective : current concepts and future prospects 显示文摘 | Zugazagoitia J Enguita AB Nunez JA | 2014 | J Thorac Dis2014，6，5： | 1 |
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