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| 1 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 2 | Digital modulation in techniques for a 34 Mbit/s radio channel using orthogonal frequency division multiplexing显示文摘 | Engels V Rohling H | 1995 | Wireless Personal Communications-Special Issue on Multi-carrier Communications1995，2，12： | 2 |
| 3 | Resonance Attractors of Spiral waves in Excitable Media under Global Feedback显示文摘 | ZYKOV V S ENGEL H | 2002 | Phys Rev2002，66，01： | 1 |
| 4 | Spatial load forecasting显示文摘 | Willis H L Engel M V Buri M J | 1995 | IEEE Computer Applications in Power1995，8，2： | 1 |
| 5 | Chilling pig carcasses:effects on temperature,weight loss and ultimate meat quality显示文摘 | VANDERWAL P G ENGEL B BEEK G V | 1995 | Meat Science1995，40，： | 1 |
| 6 | Inhibition of Growth of Experimental Human Endometrial Cancer by an Antagonist of Growth Hormone-Releasing Hormone显示文摘 | Engel Jorg B Keller Gunhild Schally Andrew V | 2005 | Joumal of Clinical Endocrinology&Metabolism2005，90，6： | 1 |
| 7 | Spatial load forecasting显示文摘 | Willis H L Engel M V Buri M J | 1995 | IEEE Computer Applications in Power1995，8，2： | 1 |
| 8 | Cell density of human lens epithelium in women higher than in men 显示文摘 | Guggenmoos-Hoizmann I Engel B Henke V | 1989 | Invest Ophthalmol Vis Sci1989，30，： | 1 |
| 9 | Evaluation of endometrial and subendometrial vascularization and endometrial volume by 3 -D power doppler ultrasound and its relationship with age and pregnancy in intrauterine insemination cycles显示文摘 | Engels V Sanfrutos L Perez -Medina T | 2011 | Gynecol Ohstet Invest2011，72，2： | 1 |
| 10 | Light and electron microscopic localization of beta-amyloid protein in muscle biopsies of patients with inclusion-body myositis显示文摘 | ASKANAS V ENGEL W K ALVAREZ R B | 1992 | Am J Pathol1992，141，1： | 1 |
| 11 | Dynamics of spiral waves under global feedback in excitable domains of different shapes显示文摘 | Zykov V Engel H | 2004 | Phys Rev E2004，70，01： | 1 |
| 12 | Photodisso-ciaiton of water in the first absorption band:a prototypefor dissociation on a repulsive potential energy surface显示文摘 | Engel V Staemmler V Vander R L | | 0，，： | 1 |
| 13 | Prion protein is abnormally accumulated in inclusion-body myositis显示文摘 | ASKANAS V BILAK M ENGEL W K | 1993 | Neuroreport1993，5，1： | 1 |
| 14 | Resonance attractors of spiral waves in excitable media under global feedback显示文摘 | Zykov V S Engel H | 2002 | Phys Rev E2002，66，01： | 1 |
| 15 | Optimizarions to Power Distribution显示文摘 | H L Willis H Tram M V Engel | | 0，，04： | 1 |
| 16 | The effect of electric fields on the burning velocity of various flames显示文摘 | JAGGERS H C ENGEL A V | | 0，，3： | 1 |
| 17 | Abnormal accumulation of prion protein mRNA in muscle fibers of patients with sporadic inclusion-body myositis and hereditary inclusion-body myopathy显示文摘 | SARKOZI E ASKANAS V ENGEL W K | 1994 | Am J Pathol1994，145，6： | 1 |
| 18 | The antiviral activity of naturally occurring proteins and their peptide fragments after chemical modification显示文摘 | Oevermann A Engels M Thomas V | 2003 | Antiviral Res2003，59，1： | 1 |
| 19 | A combined OFDM/SDMA approach 显示文摘 | Perre L V D Engels M G E | 2000 | IEEE J Select Areas Commun2000，18，11： | 1 |
| 20 | Human NKT cell express granulysin and exhibit antimicro -bacterial activity 显示文摘 | Gansert JL Kieler V Engele M | 2003 | J Immunol2003，170，6： | 1 |
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