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| 1 | A unique deubiquitinase that deconjugates phosphoribosyl-linked protein ubiquitination显示文摘Ubiquitination 调整主人免疫的许多方面并且因此是为传染代理人的一个普通目标。最近的研究表明了细菌的病原体 Legionella pneumophila 的方面受动器家庭的成员攻击不要求主人 ubiquitination 机械的 E1 和 E2 酶的新奇 ubiquitination 机制与 endoplasmic 蜂窝胃联系的几小 GTPases。在这种情况中, ubiquitin 被一项 mono-ADP-ribosyltransferase 活动被 ADP-ribosylation 首先在 Arg 42 激活;中介然后被也住在 SdeA 以内的一项 phosphodiesterase 活动劈开,有到经由一个 phosphoribosyl 连接器的底层蛋白质的丝氨酸残余的 ubiquitin 的附件的伴随物。这里,我们证明方面的效果被 SidJ 反对,一个受动器由位于为方面家庭(SdeC, SdeB 和 SdeA ) 的三个成员编码的地点的基因编码了。SidJ 由劈开连接 phosphoribosylated ubiquitin 到蛋白质底层的 phosphodiester 契约颠倒修改方面的底层的 ubiquitination。SidJ 也显示古典 deubiquitinase 活动但是不要求催化半胱氨酸残余。进一步, SidJ 的这些 deubiquitinase 活动为它在 L 的角色是必要的。pneumophila 感染。最后, SidJ 的活动为高效地在细菌的举起以后在一些小时以内在感染的房间减少许多 ubiquitinated Rab33b 被要求。我们的结果作为工作在方面受动器的活动强加时间的规定的 ubiquitin-deconjugating 酶建立 SidJ。SidJ 可能在表明串联的未来研究是重要的由这唯一的 ubiquitination 调停了,潜在地也在真核细胞的房间调整细胞的过程的。 | Jiazhang Qiu Kaiwen Yu Xiaowen Fei Yao Liu Emesto S Nakayasu Paul D Piehowski Jared B Shaw Kedar Puva Chittaranjan Das Xiaoyun Liu Zhao-Qing Luo | 2017 | Cell Research2017，27，7： | 2 |
| 2 | Correction of arterial structure and endothelial dysfunction in human EH by the angiotensin receptor antagonist losartan 显示文摘 | Emesto LS Jeong BP Hope DI | 2000 | Circulation2000，101，14： | 1 |
| 3 | The responsive legislature: Public opinion and law making in a highly disciplined legislature 显示文摘 | Emesto Calvo | 2007 | British Journal of Political Science2007，，37： | 1 |
| 4 | Energy balance measurements in a suburban vegetated area in Mexico City显示文摘 | Barradas V L Adalberto Tejeda-Martinez Emesto Jauregui | 1999 | Atmospheric Environment1999，，34： | 1 |
| 5 | Particle swarm approaches using Lozi map chaotic sequences to fuzzy modeling of an experimental thermal-vacuum system显示文摘 | Emesto A Leandro S | 2008 | Applied Soft Computing2008，8，4： | 1 |
| 6 | Supercritical fluid extraction of essential oil and related products 显示文摘 | Emesto R | 1997 | Joural of Supercritical Fluids1997，，10： | 1 |
| 7 | Robotics and Automation in Construction显示文摘 | Emesto Gambao Carlos Balaguer | | 0，，03： | 1 |
| 8 | Optimal design of horizontal-axis wind turbines using blade-dement theory and evolutionary computation 显示文摘 | Emesto Benini Andrea Toffolo | 2002 | ASME Journal of Solar Energy Engineering2002，124，： | 1 |
| 9 | Single-sided magnetic resonance profiling in biological and materials science显示文摘 | Maxime L Emesto D Juan P Blumich B | 2012 | J Magn Reson2012，215，： | 1 |
| 10 | The metastasis-associated metalloproteinase stromelysin-3 is induced by transforming growth factor-b in osteoblasts and fibroblasts显示文摘 | Anne MD Emesto C | 2001 | Endocrinology2001，142，4： | 1 |
| 11 | Optimal design of horizontal Axis wind turbines using blade, element theory and evolutionary computation 显示文摘 | Emesto Benini Andrea Toffolo | 2002 | ASME Journal of Solar Energy Engineering2002，124，： | 1 |
| 12 | A Web Service Architecture for Enforcing Access Control Policies 显示文摘 | Claudio Agestino Ardagna Emesto Damiani Sabrina De Capitani di Vimercatl Pierangela Samarati | 2006 | Electronic Notes in Theoretical Computer Science2006，142，3： | 1 |
| 13 | Radiotherapy planning: PET/CT scanner performances in the definition of gross tumour volume and clinical target volume 显示文摘 | Emesto Brianzoni Gloria Rossi | 2005 | Eur Nucl Med Mol Imaging2005，32，： | 1 |
| 14 | The flavonoids of leek, Allium porrum显示文摘 | Emesto Fattorusso Virginia Lanzotti Orazio Taglialatela- Scafati | 2001 | Phytochemistry2001，57，： | 1 |
| 15 | Silage preparation from tuna fish wastes and its nutritional evaluation in broilers显示文摘 | Luis A Vizcarra-Magana Emesto Avila Angela Sotelo | 1999 | Journal of the Science of Food and culture1999，79，13： | 1 |
| 16 | Nitrate accumulation, yield and leaf quality of turnip greens in response to nitrogen fertilization显示文摘 | Isabel S Vieira Emesto P | 1998 | Nutrient Cycling in Agroecosystems1998，51，： | 1 |
| 17 | Threshold values for domino effects caused by blast wave interaction with process equipment显示文摘 | Valerio Cozzani Emesto Salzano | 2004 | Journal of Loss Prevention in the Process Industries2004，，17： | 1 |
| 18 | The Time Is out of Joint显示文摘 | Emesto Laclau | 1995 | Diacritics1995，25，2： | 1 |
| 19 | Vascular Biology of Endothelin 显示文摘 | Emesto IS Rhian MT | 1998 | Cardiovascular Pharmacal1998，32，3： | 1 |
| 20 | Effect of capsaicin from red pepper (capsicum) on the deposition of carotenoids in egg yolk显示文摘 | Maricela Gonzalez Eduardo Castano Emesto Avila | 1999 | Sci Food Agric1999，79，： | 1 |
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