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| 1 | Reaction of antibodies to Campylobacter jejuni and cytolethal distending toxin B with tissues and food antigens显示文摘BACKGROUND The bacteria Campylobacter jejuni(C. jejuni) is commonly associated with GuillaneBarré syndrome(GBS) and irritable bowel syndrome(IBS), but studies have also linked it with Miller Fisher syndrome, reactive arthritis and other disorders, some of which are autoimmune. It is possible that C. jejuni and its toxins may be crossreactive with some human tissues and food antigens, potentially leading to autoimmune responses.AIM To measure the immune reactivity of C. jejuni and C. jejuni cytolethal distending toxin(Cdt) antibodies with tissue and food antigens to examine their role in autoimmunities.METHODS Using enzyme-linked immunosorbent assay(ELISA) methodology, specific antibodies made against C. jejuni and C. jejuni Cdt were applied to a variety of microwell plates coated with 45 tissues and 180 food antigens. The resulting immunoreactivities were compared to reactions with control wells coated with human serum albumin(HSA) which were used as negative controls and with wells coated with C. jejuni lysate or C. jejuni Cdt which served as positive controls.RESULTS At 3 SD above the mean of control wells coated with HSA or 0.41 OD, the mouse monoclonal antibody made against C. jejuni showed moderate to high reactions with zonulin, somatotropin, acetylcholine receptor, β-amyloid and presenilin.This immune reaction was low with an additional 25 tissue antigens including asialoganglioside, and the same antibody did not react at all with another 15 tissue antigens. Examining the reaction between C. jejuni antibody and 180 food antigens, we found insignificant reactions with 163 foods but low to high immune reactions with 17 food antigens. Similarly, we examined the reaction of C. jejuni Cdt with the same tissues and food antigens. The strongest reactions were observed with zonulin, intrinsic factor and somatotropin. The reaction was moderate with 9 different tissue antigens including thyroid peroxidase, and reaction was low with another 10 different antigens, including neuronal antigens.The reaction of C. jejuni Cdt antibody with an additional 23 tissue antigens was insignificant. Regarding the reaction of C. jejuni Cdt antibody with different food antigens, 160 out of 180 foods showed insignificant reactions, while 20 foods showed reactions ranging from low to high.CONCLUSION Our findings indicate that C. jejuni and its Cdt may play a role in inflammation and autoimmunities beyond the gut. | Aristo Vojdani Elroy Vojdani | 2019 | World Journal of Gastroenterology2019，25，9： | 3 |
| 2 | Abdominal tuberculosis: Is there a role for surgery?显示文摘It is important that surgeons are familiar with the various manifestations of tuberculosis(TB). Although TB has been declining in incidence in the developed world, itremains an important problem in endemic areas of the developing world. The aim of the review was to elucidate the natural history and characteristics of abdominal TB and ascertain the indications for surgery. TB can affect the intestine as well as the peritoneum and the most important aspect of abdominal TB is to bear in mind the diagnosis and obtain histological evidence. Abdominal TB is generally responsive to medical treatment, and early diagnosis and management can prevent unnecessary surgical intervention. Due to the challenges of early diagnosis, patients should be managed in collaboration with a physician familiar with anti-tuberculous therapy. An international expert consensus should determine an algorithm for the diagnosis and multidisciplinary management of abdominal TB. | Elroy Patrick Weledji Benjamin Thumamo Pokam | 2017 | World Journal of Gastrointestinal Surgery2017，9，8： | 2 |
| 3 | In situ expression of platelet-derived growth factor (PDGF-beta) during chronic rejection is abolished by retransplantation 显示文摘 | Yang HC Mc Elroy RJ Kreider JW | 1995 | J Surg Res1995，59，： | 1 |
| 4 | Species-specific effects on non-enzymatic metmyoglobin reduction in vitro显示文摘 | Elroy NN Rogers J Marl GG | 2015 | Meat Science2015，105，： | 1 |
| 5 | A52-week open-label continuation study of lamotrigine in the treatment of bipolar depression显示文摘 | Mc Elroy SL Zarate CA Cookson J | 2004 | J Clin Psychiatry2004，65，2： | 1 |
| 6 | Efficacy of the Type 2 Diabetes Prevention Using LifeStyle Education Program RCT显示文摘 | Elroy J. Aguiar Philip J. Morgan Clare E. Collins Ronald C. Plotnikoff Myles D. Young Robin Callister | 2016 | American Journal of Preventive Medicine2016，，3： | 1 |
| 7 | China’s CO2emissions estimated from the bottom up:Recent trends spatialdistributions and quantification of uncertainties显示文摘 | Zhao Yu Chris P Nielsen Michael B Mc Elroy | 2012 | Atmospheric Environment2012，，5： | 1 |
| 8 | Tall fescue seedling tolerance to carfentrazone,bromoxynil,quinclorac,and siduron显示文摘 | Mc Elroy J S Breeden G K | 2006 | Hort Science2006，41，1： | 1 |
| 9 | Tourism and crismein the Caribbeat显示文摘 | DEAL BUQUERQUE K ELROY J M C | 1999 | Annals of Tourism Research1999，26，4： | 1 |
| 10 | Constitutive expression of a cowpea trypsin inhibitor gene,CpTi,in transgenie rice plants confers resistance to two mainr rice insect pests显示文摘 | Xu D Xue Q Me Elroy D | 1996 | Molecular Breeding1996，2，2： | 1 |
| 11 | Murphy's law and market anomalies显示文摘 | Elroy Dimson Paul Marsh | 1999 | Journal of Portfolio Management1999，25，2： | 1 |
| 12 | The production of polyclonal antibodies against the mycotoxin derivative Patulin hemiglutarate显示文摘 | Mc Elroy L J Weiss C M | 1993 | Canadian journal of microbiology1993，39，9： | 1 |
| 13 | Anefficient method for dispersing Ds elements in the barley genome as atoll for determining gene function显示文摘 | Mc Elroy D Louwerse J | 2000 | Plant J2000，24，： | 1 |
| 14 | Physiological chages from 58 Year of genetic improvement of short season soybean cultivars in Canada显示文摘 | Morrison J M Harvery D V Elroy R C | 1999 | Agronomy Journal1999，91，： | 1 |
| 15 | Size distribution of fine particles from coal combustion显示文摘 | Mc Elroy M W Carr R C Ensor D S | 1982 | Science1982，215，1： | 1 |
| 16 | A double-blind,placebo-controlled study of quetiapine and paroxetine as monotherapy in adults with bipolar depression(EMBOLDEN II)显示文摘 | Mc Elroy SL Weisler RH Chang W | 2010 | J Clin Psychiatry2010，71，2： | 1 |
| 17 | A double-blind,placebo-controlled study of quetiapine and lithium monotherapy in adults in the acute phase of bipolar depression(EMBOLDEN I)显示文摘 | Young AH Mc Elroy SL Bauer M | 2010 | J Clin Psychiatry2010，71，2： | 1 |
| 18 | Physiological changes from 58 years of genetic improvement of short-season soybean cultivars in Canada显示文摘 | Morrison Malcolm J Harvey D Voldeng Elroy R Cober | 1999 | Agronomy Journal1999，91，： | 1 |
| 19 | Controlling weed in dormant and nondormant alfalfa (Medicago sativa ) 显示文摘 | Elroy J P Mckelvey R A Mattas R | 1984 | Weed Science1984，32，： | 1 |
| 20 | IPO Underpricing over the Very Long Run 显示文摘 | David Chambers and Elroy Dimson | 2009 | The Journal Of FinanceI2009，2009，： | 1 |
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