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| 1 | First isolation of glutinol and a bioactive fraction with good antiinflammatory activity from n-hexane fraction of Peltophorum africanum leaf显示文摘Objective: To investigate the anti-inflammatory activity of different fractions and glutinol(isolated compound),using nitric oxide synthase and cyclooxygenase(COX) inhibition as an indication of anti-inflammatory activity,Methods: Anti-inflammatory activity was evaluated using an in vitro assay determining the inhibition of the activity of pro-inflammatory enzyme model,Cyclooxygenases and inducible nitric oxide synthase are crucial enzymes involved in the pathogenesis of many chronic inflammatory conditions,Results: Sub-fraction F3.3 that was derived from n-hexane fraction of PA leaves significantly inhibited(P = 0.01) the catalytic activity of COX-2(IC50 = 0.67 μg/m L) better than isolated compound,glutinol(IC50 = 1.22 μg/m L),compound 2(CP2)(IC50 = 1.71 μg/m L) and sub-fraction F3.3.0(IC50 = 1.30 μg/m L),A similar trend was observed in investigation of the inhibition of nitric oxide synthesis in RAW 264.7 cells by F3.3,glutinol,CP2 and F3.3.0,Inducible COX-2 and inducible nitric oxide synthase are among potent signalling enzymes that exacerbate inflammation,Conclusions: Bioactive sub-fractions(F3.3 and F3.3.0) derived from the n-hexane fraction of PA had good anti-inflammatory activity,and the isolated compound,and glutinol may be useful as a template for the development of new anti-inflammatory drugs. | Salmon A Adebayo Leshweni J Shai Jacobus N Eloff | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，1： | 2 |
| 2 | A Sensitive and Quick Microplate Method to Determine the Minimal Inhibitory Concentration of Plant Extracts for Bacteria显示文摘 | J. Eloff | 1998 | Planta Med1998，，08： | 2 |
| 3 | The effect of temperature on specific growth rate and activation energy of Microcystis and Synechococcus isolates relevant to the onset of natural blooms 显示文摘 | Kruger G H J Eloff J N | 1978 | Journal of the Limnological Society of Southern Africa1978，4，： | 1 |
| 4 | Effect of temperature and light on the toxicity and growth of the blue-green alga Microcystis aeruginosa ( UV- 006 ) 显示文摘 | Van der Westhuizen A J Eloff J N | 1985 | Plant1985，163，： | 1 |
| 5 | Access Control in Document-centric Workflow Systems-An Agent-based Approach显示文摘 | Reinhardt A Botha Jan H P Eloff | 2001 | Computers & Security2001，20，6： | 1 |
| 6 | A Framework and Assessment Instrument for Information Security Culture 显示文摘 | Vciga A Eloff J | 2010 | Computers & Security2010，，29： | 1 |
| 7 | Biological activity of five antibacterial flavonoids from Combretum erythrophyllum (Combretaceae)显示文摘 | ND Mertini DRP Katerere JN Eloff | 2005 | Journal of Ethnopharmacology2005，102，： | 1 |
| 8 | Pharmacological modulation of cardiac gap junctions to enhance cardiac conduction:evidence supporting a novel target for antiarrhythmic therapy显示文摘 | Gilat E Wan X | 2003 | Circulation2003，108，25： | 1 |
| 9 | A Common Criteria Framework for the E- valuation ,gf Information Technology Systems Security 显示文摘 | Kruger R Eloff J H P | 1997 | Computers and Security1997，16，3： | 1 |
| 10 | Food safety:importance of composi- tion for assessing genetically modified cassava(Manihot esculenta Crantz) 显示文摘 | van Rijssen FW Morris EJ Eloff JN | 2013 | J Agric Food Chem2013，61，35： | 1 |
| 11 | The use of Real-time Risk Analysis to enable dynamic activation of countermeasures显示文摘 | L Labuschagne JHP Eloff | 1998 | Computers & Security1998，17，4： | 1 |
| 12 | Effect of temperature and light on the toxicity and growth of the blue-green alga Microcystis aeruginosa (UV-006)显示文摘 | A. J. Westhuizen J. N. Eloff | 1985 | Planta1985，，1： | 1 |
| 13 | A Sensitive and Quick Microplate Method to Determine the Minimal Inhibitory Concentration of Plant Extracts for Bacteria显示文摘 | J. Eloff | 1998 | Planta Med1998，，08： | 1 |
| 14 | Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects显示文摘 | Petrich BG Eloff BC Lerner DL | 2004 | J Biol Chem2004，279，15： | 1 |
| 15 | Enhanced password authenticationthrough fuzzy logic显示文摘 | De Ru W G Eloff J H P | 1997 | IEEE Expert1997，12，6： | 1 |
| 16 | Assessment of dermal exposure and skin condition of workers exposed to nickel at a South African base metal refinery 显示文摘 | Du Plessis Johannes L Eloff Frederik C Badenhorst Casper J | 2010 | Annals of occupa- tional hygiene2010，54，1： | 1 |
| 17 | Planning the Safety of Atrial Fibrillation Ablation Registry Initia- tive(SAFARI)as a Collaborative Pan-Stakeholder Critical Path Registry Model:a Cardiac Safety Research Consortium 'Incubator'Think Tank 显示文摘 | Al-Khatib S M Calkins H Eloff B C | 2010 | American heart journal2010，159，1： | 1 |
| 18 | Effect of temperature and light on the toxicity and growth of the blue-green alga Microcystis aeruginosa (UV-006)显示文摘 | A. J. Westhuizen J. N. Eloff | 1985 | Planta1985，，1： | 1 |
| 19 | Biological activity of five antibacterial flavonoids from Combretum erythrophyllum(Combretaceae)显示文摘 | Martini N D Katerere D R P Eloff J N | 2004 | Ethnopharmacology2004，93，： | 1 |
| 20 | Screening of twenty-four south African Combretum and six Terminalla species(Combretaceae) for antioxidantactivity显示文摘 | MASOKOAB P ELOFF J N | 2007 | Complementary and Alternative Medicines2007，4，2： | 1 |
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