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| 1 | Introducing an enhanced recovery after surgery program in colorectal surgery:A single center experience显示文摘AIM:To study the implementation of an enhanced recovery after surgery(ERAS)program at a large University Hospital from'pilot study'to'standard of care'.METHODS:The study was designed as a prospective single centre cohort study.A prospective evaluation of compliance to a protocol based on full application of all ERAS principles,through the progressive steps of its implementation,was performed.Results achieved in the initial pilot study conducted by a dedicated team(n=47)were compared to those achieved in the shared protocol phase(n=143)three years later.Outcomes were length of postoperative hospital stay,readmission rate,compliance to the protocol and morbidity.Primary endpoint was the description of the results and the identification of critical issues of large scale implementation of an ERAS program in colorectal surgery emerged in the experience of a single center.Secondary endpoint was the identification of interventions that have been proven to be effective for facilitating the transition from traditional care pathways to a multimodal management protocol according to ERAS principles in colorectal surgery at a single center.RESULTS:During the initial pilot study(March 2009 to December 2010;47 patients)conducted by a dedicated multidisciplinary team,compliance to the items of ERAS protocol was 93%,with a median length of hospital stay(LOS)of 3 d.Early anastomotic fistulas were observed in 2 cases(4.2%),which required reoperation(Clavien-Dindo gradeⅢb).None of the patients had been discharged before the onset of the complication,which could therefore receive prompt treatment.There were also four(8.5%)minor complications(ClavienDindo gradeⅡ).Thirty days readmission rate was 4%.Perioperative mortality was nil.After implementation of the protocol throughout the Hospital in unselected patients(May 2012 to December 2012;147 patients)compliance was 74%,with a median LOS of 6 d.Early anastomotic fistulas were observed in 11 cases(7.7%),5(3.5%)of which required reoperation(Clavien-Dindo gradeⅢb).Two early anastomotic fistulas were treated by radiologic/endoscopic manoeuvres and 4 were treated conservatively.There were also 36(25.2%)minor complications,21(14.7%)of which were Clavien-Dindo gradeⅡand 15(10.5%)of which were Clavien-Dindo gradeⅠ.Only two patients whose course was adversely affected by the development of an anastomotic leak had been discharged before the onset of the complication itself,requiring readmission.Readmission rate within 30 d was 4%.Perioperative mortality was 1%.CONCLUSION:Our results confirm that introduction of an ERAS protocol for colorectal surgery allows quickerpostoperative recovery and shortens the length of stay compared to historical series. | Stefano Bona Mattia Molteni Riccardo Rosati Ugo Elmore Pietro Bagnoli Roberta Monzani Monica Caravaca Marco Montorsi | 2014 | World Journal of Gastroenterology2014，20，46： | 30 |
| 2 | The Role of the Plasma Membrane H+-ATPase in Plant-Microbe Interactions显示文摘 | James Mitch Elmore Gitta Coaker | 2011 | Molecular Plant2011，4，3： | 10 |
| 3 | Laparoscopic Rectal Resection for Cancer: Effects of Conversion on Short-Term Outcome and Survival显示文摘 | Matteo Rottoli Stefano Bona Riccardo Rosati Ugo Elmore Paolo P. Bianchi Antonino Spinelli Cristina Bartolucci Marco Montorsi | 2009 | Annals of Surgical Oncology2009，，： | 2 |
| 4 | In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER) {alpha} and ER {beta} null mice indicate a role for ER {beta} in follicular maturation 显示文摘 | Emmen JM Couse JF Elmore SA | 2005 | Endocrinology2005，146，6： | 1 |
| 5 | High performance waterborne coatings based on dispersions of a solid epoxy resin and an amine-functional curing agent 显示文摘 | Galgoei E C P Komar C Elmore J D | 1999 | Journal of Coatings Technology1999，71，891： | 1 |
| 6 | Two-fibre solid-phase microextraction combined with gas chromatography-mass spectrometry for the analysis of volatile aroma compounds in cooked pork 显示文摘 | Elmore J S Mottram D S Hierro E | 2000 | Journal of Chromatography A2000，905，1： | 1 |
| 7 | The mitochondrial permea-bility transition initiates autophagy in rat hepatocytes显示文摘 | Elmore SP Qian T Grissom SF | 2001 | FASEB J2001，15，12： | 1 |
| 8 | Perinatal toxicity and carcinogenicity studies of styrene-acrylonitrile trimer, a ground water contaminant显示文摘 | Behl M Elmore SA Malarkey DE | 2013 | Toxicology2013，314，1： | 1 |
| 9 | The effect of lipid composition on meat-like model systems containing cysteine, ribose and polyunsaturated fatty acids 显示文摘 | Elmore J S Campo M Enser M | 2002 | Journal of Agricultural and Food Chemistry2002，50，2： | 1 |
| 10 | Amino acid composition of germinating cotton seeds 显示文摘 | ELMORE C D KING E E | 1978 | Plant Physiol1978，62，4： | 1 |
| 11 | Apoptosis: A review of programmed cell death 显示文摘 | Elmore S | 2007 | Toxicologic Pathology2007，35，4： | 1 |
| 12 | Selection of diurnal roosts by red bats(Lasiurus borealis)in an intensively managed pine for est in Mississippi显示文摘 | Elmore L W Miller D A ViIella F J | 2004 | Forest Ecology and Management2004，199，1： | 1 |
| 13 | Apoptosis:A review of programmed cell death显示文摘 | Elmore S | 2007 | Toxi-col Pathol2007，35，4： | 1 |
| 14 | Waterborne epoxy protectivecoatings for metal显示文摘 | Elmore J D Kincaid D S Komar P C | 2002 | Journal of Coatings Technology2002，74，931： | 1 |
| 15 | Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis显示文摘 | Elmore LW Hancock AR Chang SF | 1997 | Proc Natl Acad Sci USA1997，94，14： | 1 |
| 16 | Weed management systemsfor conventional and glyphosate-resistant soybean with and without ir-rigation显示文摘 | Heatherly L G Elmore C D Spurlock S R | 2002 | Agronomy Journal2002，94，6： | 1 |
| 17 | The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy 显示文摘 | Lemasters J J Nieminen AL Qian T Trost LC Elmore SP Nishimura Y | 1998 | Biochim Biophys Acta1998，1366，12： | 1 |
| 18 | A preliminary study of the dermal absorption of aluminium from antiperspirants using aluminium-26 显示文摘 | FLAREND R BIN T ELMORE D | 2001 | Food Chem Toxicol2001，39，2： | 1 |
| 19 | Global patterns offo- liar nitrogen isotopes and their relationships with climate, mycor- rhizal fungi foliar nutrient concentrations and nitrogen availability 显示文摘 | Craine J M Elmore A J Aidar M P | 2009 | New Phytologist2009，183，4： | 1 |
| 20 | Challenges in ductalcarcinoma in situ risk communication and decision-making: reportfrom an American Cancer Society and National Cancer Instituteworkshop显示文摘 | Partridge AH Elmore JG Saslow D | 2012 | CA Cancer J Clin2012，62，3： | 1 |
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