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| 1 | Combination antiretroviral studies for patients with primary biliary cirrhosis显示文摘Following the characterization of a human betaretrovirus in patients with primary biliary cirrhosis(PBC),pilot studies using antiretroviral therapy have been conducted as proof of principal to establish a link of virus with disease and with the eventual aim to find better adjunct therapies for patients unresponsive to ursodeoxycholic acid.In the first open label pilot study,the reverse transcriptase inhibitor lamivudine had little demonstrable biochemical or histological effect after 1 year.Whereas,lamivudine in combination with zidovudine was associated with a significant reduction in alkaline phosphatase as well as improvement in necroinflammatory score,cholangitis and ductopenia over a 12 mo period.A double blind,multi-center randomized controlled trial using lamivudine with zidovudine for 6 mo confirmed a significant reduction in alkaline phosphatase,ALT and AST in patients on antiviral therapy.However,none of the patients achieved the stringent endpoint criteria for normalization of alkaline phosphatase.Furthermore,some patients developed biochemical rebound consistent with drug resistance.A major fault of these studies has been the inability to measure the viral load in peripheral blood and therefore,provide a direct correlation between improvement of hepatic biochemistry and reduction in viral load.Nevertheless,viral mutants to lamivudine with zidovudine were later characterized in the NOD.c3c4 mouse model of PBC that has been used to test other antiretroviral regimens to betaretrovirus.The combination of tenofovir and emtricitabine reverse transcriptase inhibitors and the HIV protease inhibitor,lopinavir were found to abrogate cholangitis in the NOD.c3c4 mouse model and the same regimen normalized the liver tests in a PBC patient with HIV and human betaretrovirus infection.This combination antiretroviral therapy has now been used in a double blind randomized controlled crossover study for patients with PBC followed by an open label extension study.Only a third of the PBC patients were able to tolerate the lopinavir but those maintained on tenofovir,emtricitabine and lopinavir experienced sustained and clinically meaningful reduction in hepatic biochemistry.While we await the histological and virological evaluation,it is clear that better tolerated regimens of antiretroviral treatment will be required in future clinical trials. | Ellina Lytvyak Aldo J Montano-Loza Andrew L Mason | 2016 | World Journal of Gastroenterology2016，22，1： | 2 |
| 2 | Extracellular matrix-associated (GAGs, CTGF), angiogenic (VEGF) and inflammatory factors (MCP-1, CD40, IFN-γ) in type 1 diabetes mellitus nephropathy显示文摘 | Olga Ellina Antonios Chatzigeorgiou Sophia Kouyanou Maria Lymberi Christina Mylona-Karagianni Emmanouil Tsouvalas Elli F. Kamper | 2011 | Clinical Chemistry and Laboratory Medicine2011，，1： | 2 |
| 3 | The hydrogen-induced modification of the properties of the metal surface coated with oil and lubricant显示文摘 | Lunarska Ellina Samatowicz Danuta | 2000 | Trihology International2000，33，7： | 1 |
| 4 | Study of high amylose corn starch as food grade enteric coating in a microcapsule model system 显示文摘 | Anna Dimantov Menahem Greenberg Ellina Kesselman | 2004 | Innovative Food Science and Emerging Technologies2004，，5： | 1 |
| 5 | Serum soluble urokinase plasminogen activator receptor as a screening test for the early diagnosis of hepatocellular carcinoma显示文摘 | Athina Chounta Christofer Ellinas Vassiliki Tzanetakou Fani Pliarhopoulou Virginia Mplani Angelos Oikonomou Kostantinos Leventogiannis Evangelos J. Giamarellos‐Bourboulis | 2015 | Liver Int2015，，2： | 1 |
| 6 | Discrimination and Politi- cal Violence: A Cross-National Study with Two Time Periods显示文摘 | Ellina Maro Will H. Moore | | 0，，： | 1 |
| 7 | Mechanics of Ship/Jack-up Collisions显示文摘 | Ellinas C P | 1995 | Construct Steel Research1995，33，： | 1 |
| 8 | Stereo image compression using wavelet coefficients morphology 显示文摘 | Ellinas J N Sangriotis M S | 2004 | Image and Vision Computing2004，22，4： | 1 |
| 9 | Pipeline design based on strain criteria 显示文摘 | ELLINAS C P | 1999 | Chemical Business1999，13，5： | 1 |
| 10 | Bilateral primary lymphoma of the breast:a case report initially diagnosed by FNAC显示文摘 | Manunis N Ellina E Papadaki TH | | 0，，02： | 1 |
| 11 | US of the shoulders: rotatorcuff and non-rotator cuff disorders显示文摘 | Papatheodorou A Ellinas P Takis F | 2006 | Radiograhics2006，，26： | 1 |
| 12 | Cholestatic liver injury after glimepiride therapy显示文摘 | Chounta A Zouridakis S Ellinas C | 2005 | J Hepatol2005，42，6： | 1 |
| 13 | Key Enabling Technologies for Optical-Wireless Networks: Optical Millimeter-Wave Generation, Wavelength Reuse, and Architecture 显示文摘 | ZHENSHENG JIA JIANJUN YU GEORGIOS ELLINAS | 2007 | Journal of Lightwave Technology2007，25，11： | 1 |
| 14 | Stereo image compressionusing wavelet coefficients morphology显示文摘 | Ellinas J N Sangriotis M S | 2004 | Image and Vision Computing2004，22，4： | 1 |
| 15 | Protection cycles in mesh WDM networks显示文摘 | Ellinas G Hailemariam A G Stern T E | 2000 | IEEE Journal on Selected Areas in Communications2000，18，10： | 1 |
| 16 | Lightpath-and light-tree-based group cast routing and wavelength assignment in mesh optical networks显示文摘 | Rahman T Ellinas G Ali M | 2009 | Journal of Optical Communications and Networking2009，1，2： | 1 |
| 17 | Key Enabling Technologies for Optical -Wireless Networks: Optical Millimeter-Wave Generation, Wavelength Reuse, and Architecture 显示文摘 | JIA Z YU J ELLINAS G | 2007 | Journal of Lightwave Technology2007，25，11： | 1 |
| 18 | Stereo Image Compression Using Wavelet Coefficients Morphology 显示文摘 | ELLINAS J N SANGRIOTIS M S | 2004 | Image and Vision Computing2004，22，： | 1 |
| 19 | Collision Damage of Jack-ups显示文摘 | Charles P Ellinas Raymond Kwok Kevin A J Williams | 1989 | Marine Structure1989，2，35： | 1 |
| 20 | Mechanism of textural changes induced by microwave reheating of a surimi shrimp imitation显示文摘 | UZZANA M ELLINA K RAMONB O | 2006 | Journal of Food Engineering2006，74，2： | 1 |
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