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| 1 | Flare-up rate in pulpally necrotic molors in one-visit versus two-visit endodontic treatment显示文摘 | Eleazer P D Eleazer K R | | 0，，09： | 1 |
| 2 | Flare up rate in pulpally necrotic molars in one visit versus two visit endodontic treatment显示文摘 | Eleazer P D Eleazer K R | | 0，，05： | 1 |
| 3 | Clearance of biofilms from dental unit waterlines through the use of hydroperoxide ion-phase transfer catalysts显示文摘 | P A Shepherd M A Shojaei P D Eleazer | 2001 | Quintessence International Dental Digest2001，32，10： | 1 |
| 4 | A comparison of torque required to fracture rotary files with tips bound in simulated curved canal显示文摘 | Guilford W I Lemons F E Eleazer P D | 2005 | J Endod2005，31，： | 1 |
| 5 | Flare-up rate in pulpally necrotic molars in, one-visit versus two-visit endodontic treatment显示文摘 | Eleazer P D Eleazer K R | 1998 | Journal of Endodontics1998，24，9： | 1 |
| 6 | Detoxification of endotoxin by endodontic irrigants and calcium hydroxide显示文摘 | Buck R A Cai J Eleazer P D | 2001 | J Endod2001，27，5： | 1 |
| 7 | Detoxification of endotoxin by endodonfic imgants and caleinm hydroxide 显示文摘 | Buckra P Eleazer D | 2001 | J Endod2001，27，5： | 1 |
| 8 | Flare - up rate in pnlpally necrot- ic molars in one -visit versus two -visit endodontic treatment显示文摘 | ELEAZER P D ELEAZER K R | 1998 | J Endodon1998，24，9： | 1 |
| 9 | Geriatric content in medical school curricula: results of a national survey显示文摘 | Eleazer GP Doshi R Wieland D | 2005 | J Am Geriatr Soc2005，53，1： | 1 |
| 10 | Hare-up rate in pulpally necrotic molors in one visit verustw-visit endodontic treatment显示文摘 | Eleazer D Eleazer K | 1998 | J Endod1998，24，9： | 1 |
| 11 | Inhibition of Rgs10 Expression Prevents Immune Cell Infiltration in Bacteria-induced Inflammatory Lesions and Osteoclast-mediated Bone Destruction显示文摘Regulator of G-protein Signaling 10(Rgs10)plays an important function in osteoclast differentiation.However,the role of Rgs10 in immune cells and inflammatory responses,which activate osteoclasts in inflammatory lesions,such as bacteria-induced periodontal disease lesions,remains largely unknown.In this study,we used an adeno-associated virus(AAV-)mediated RNAi(AAV-shRNA-Rgs10)knockdown approach to study Rgs10’s function in immune cells and osteoclasts in bacteria-induced inflammatory lesions in a mouse model of periodontal disease.We found that AAV-shRNA-Rgs10 mediated Rgs10 knockdown impaired osteoclastogenesis and osteoclast-mediated bone resorption,in vitro and in vivo.Interestingly,local injection of AAV-shRNA-Rgs10 into the periodontal tissues in the bacteria-induced inflammatory lesion greatly decreased the number of dendritic cells,T-cells and osteoclasts,and protected the periodontal tissues from local inflammatory damage and bone destruction.Importantly,AAV-mediated Rgs10 knockdown also reduced local expression of osteoclast markers and pro-inflammatory cytokines.Our results demonstrate that AAVshRNA-Rgs10 knockdown in periodontal disease tissues can prevent bone resorption and inflammation simultaneously.Our data indicate that Rgs10 may regulate dendritic cell proliferation and maturation,as well as the subsequent stimulation of T-cell proliferation and maturation,and osteoclast differentiation and activation.Our study suggests that AAV-shRNA-Rgs10 can be useful as a therapeutic treatment of periodontal disease. | Sen Yang Liang Hao Matthew McConnell Xuedong Zhou Min Wang Yan Zhang John D Mountz Michael Reddy Paul D. Eleazer Yi-Ping Li Wei Chen | 2013 | Bone Research2013，1，3： | 0 |
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