|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 短暂性脑缺血发作的定义和评价:美国心脏协会/美国卒中协会卒中委员会、心血管外科和麻醉委员会、心血管放射学和介入委员会、心血管护理委员会和外周血管病跨学科委员会对医疗卫生专业人员发布的科学声明:美国神经病学学会确认该声明作为神经科医生继续教育工具的价值显示文摘本科学声明面向为短暂性脑缺血发作(transient ischemic attacks,TIA)患者提供医疗诊治的临床医生和相关医疗卫生人员。采用正规的证据复习方法对1990-2007年7月期间Medline数据库进行系统的文献检索,并运用证据表、汇总分析和病例资料的合并分析,对数据进行综合处理。本文支持以下基于组织学的TIA定义:局灶性脑、脊髓或视网膜缺血引起的短暂性神经功能障碍发作,且无急性脑梗死。TIA患者的近期卒中风险较高,可根据临床量表、血管影像学和磁共振弥散加权成像进行风险分层。诊断推荐包括:TIA患者应在发病24h内接受神经影像学评价,最好是应用包括弥散序列在内的MRI;应进行无创性颈部血管成像检查,最好是无创性颅内血管成像;对于未能确定血管病因的患者,TIA发病后应尽快进行心电图检查,也应考虑持续心电监测和超声心动图检查;应进行常规血液化验;对于发病72h内就诊并且ABCD^2评分≥3分(提示近期复发风险较高)或在门诊不能迅速完成诊断评价的TIA患者,应收入院治疗。 | J. Donald Easton Jeffrey L. Saver Gregory W. Albers Mark J. Alberts Seemant Chaturvedi Edward Feldmann Thomas S. Hatsukami Randall T. Higashida S. Claibome Johnston Chelsea S. Kidwell Helmi L. Lutsep Elaine Miller Ralph L. Sacco 李海峰 高翔(译) | 2009 | 国际脑血管病杂志2009，，9： | 86 |
| 2 | 中国妇女妊娠前后单纯服用叶酸对神经管畸形的预防效果显示文摘目的 评价妇女在妊娠前后服用单纯 40 0 μg叶酸增补剂对胎 /婴儿神经管畸形 (NTDs)的预防效果。方法 1993~ 1995年在中国北方的NTDs高发地区和南方的NTDs低发地区妇女增补叶酸的推广项目中 ,共募集从孕前或孕后任何时间开始服药的妇女 130 142名 ,未服药的妇女 1176 89名 ;设计的服药方法从婚检时开始到孕满 3个月为止 ,每天服用单纯叶酸片 40 0 μg ;最后对妇女的分娩结局进行监测并进行预防效果的对比评价研究。结果 服药组妇女生育的胎婴儿中共发现 10 2例NTDs ,对照组胎婴儿中共发现 173例NTDs。末次月经前募集的未服药妇女在孕 2 0周以后分娩的胎婴中NTDs发生率 ,北方为 4 8‰ (16 / 3 318) ,南方为 1 0‰ (2 8/ 2 82 6 5 ) ,而妊娠前后服药妇女组则分别为1 0‰ (13/ 13 0 12 )和 0 6‰ (34/ 5 86 38)。与末次月经前募集的未服药妇女组相比 ,北方服药妇女NTDs发生率明显降低 ,其中依从性大于 80 %的服药组妇女预防率达 85 % (95 %CI为 6 2 %~ 94% ) ,南方地区服叶酸的预防率为 41% (95 %CI为 3 %~ 6 4% )。结论 妇女在妊娠前后每天服用单纯叶酸 40 0 | 李竹 RobertJ Berry 李松 J David Erickson 王红 Cynthia A Moore 赵平 Joseph Mulinare 洪世欣 Lee-Yang C Wong 呼和牧人 Jacqueline Gindler 郝玲 Adolfo Correa 朱慧萍 Elaine Gunter | 2000 | 中华医学杂志2000，80，7： | 185 |
| 3 | 风险规避与中国棉农的农药施用行为显示文摘过量施用农药现象在中国农作物生产中普遍存在,本文使用2006~2007年240个棉衣、1429个地块的实地调查数据,结合对农民风险规避程度的实验结果,对风险规避与农民农药施用行为之间的关系进行了实证分析。研究结果表明,农民的风险规避程度对其农药施用行为具有三个方面的重要影响:①具有较高风险规避程度的农民会施用更多的农药来避免可能发生的虫害损失;②具有较高风险规避程度的农民会选择更多种类的农药来避免农业生产的不确定性,以保证农药施用能够有效控制虫害和减少损失;③具有较高风险规避程度的农民会选择购买价格较高的农药。此外,本文也发现,农民对病虫害防治知识的掌握程度对其农药施用行为也有一定影响。因此,提高农民的农业技术知识水平有助于减少农药施用量。 | 米建伟 黄季焜 陈瑞剑 Elaine M.Liu | 2012 | 中国农村经济2012，，7： | 69 |
| 4 | 影响男性参与计划生育的因素:中国定性研究的发现显示文摘本项目于1993~1994年在中国开展。为达到研究的预期目的,在方法学方面采用定性研究技术,即通过集体访谈(FGDs)和个人深入访谈的方式来获取各类访谈对象的观念和行为方面的广泛信息,以探究影响男性参与的深层原因。访谈现场确定在四川、云南和吉林三省。本项目集体访谈对象类型主要包括避孕套使用者及其妻子,五年内男扎接受者及其妻子,采用女性方法的妇女及其丈夫等;个人访谈对象类型主要包括政策制定者、项目管理者、节育技术提供者和宗教领袖等。各省现场调查结束后,研究者使用统一拟定的提纲对集体访谈资料进行观点归类,并以个人访谈获取的关键信息加以补充,进而找出研究之主要发现。研究结果提示,影响男性参与计划生育的因素主要涉及政策与宣传、服务与技术、地理与文化和社会与心理等相互联系的诸多方面。根据主要发现提出的建议要点主要包括改善决策者男扎方面的知识,制定出有利于男性参与的鼓励性政策;加强避孕套提供过程的全面质量管理;进一步提高男扎服务质量并制定切实可行的规范;通过各种渠道宣传男扎知识,改进服务提供者的人际交流技巧,为广大群众提供咨询服务,进一步改善男性参与计划生育的意识并分担责任。 | 刘云嵘 吴世仲 罗琳 郭建 唐莉莎 彭林 李长华 苏兰芬 吴亚平 任涛 兰育智 周连福 李季 赫欣 陈昆 李南伊 Elias Wells Joan Haffy Elaine Douglas | 1995 | 中国计划生育学杂志1995，3，1： | 15 |
| 5 | Vertical Nanowire Array-Based Light Emitting Diodes显示文摘Electroluminescence from a nanowire array-based light emitting diode is reported.The junction consists of a p-type GaN thin fi lm grown by metal organic chemical vapor deposition(MOCVD)and a vertical n-type ZnO nanowire array grown epitaxially from the thin fi lm through a simple low temperature solution method.The fabricated devices exhibit diode like currentvoltage behavior.Electroluminescence is visible to the human eye at a forward bias of 10 V and spectroscopy reveals that emission is dominated by acceptor to band transitions in the p-GaN thin fi lm.It is suggested that the vertical nanowire architecture of the device leads to waveguided emission from the thin fi lm through the nanowire array. | Elaine Lai Woong Kim Peidong Yang | 2008 | Nano Research2008，1，2： | 13 |
| 6 | The Chinese skeleton: insights into microstructure that help to explain the epidemiology of fracture显示文摘Osteoporotic fractures are a major public health problem worldwide, but incidence varies greatly across racial groups and geographic regions. Recent work suggests that the incidence of osteoporotic fracture is rising among Asian populations. Studies comparing areal bone mineral density and fracture across races generally indicate lower bone mineral density in Asian individuals including the Chinese, but this does not reflect their relatively low risk of non-vertebral fractures. In contrast, the Chinese have relatively high vertebral fracture rates similar to that of Caucasians. The paradoxically low risk for some types of fractures among the Chinese despite their low areal bone mineral density has been elucidated in part by recent advances in skeletal imaging.New techniques for assessing bone quality non-invasively demonstrate that the Chinese compensate for smaller bone size by differences in hip geometry and microstructural skeletal organization. Studies evaluating factors influencing racial differences in bone remodeling, as well as bone acquisition and loss, may further elucidate racial variation in bone microstructure. Advances in understanding the microstructure of the Chinese skeleton have not only helped to explain the epidemiology of fracture in the Chinese, but may also provide insight into the epidemiology of fracture in other races as well. | Elaine Cong Marcella D Walker | 2014 | Bone Research2014，2，2： | 13 |
| 7 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 8 | Traditional Chinese Medicine as a Treatment for Rheumatoid Arthritis:From Empirical Practice to Evidence-Based Therapy显示文摘Rheumatoid arthritis(RA)is a common autoimmune condition with an elusive etiology.Conventional and biological disease-modifying drugs sometimes fail or produce only partial responses.Traditional Chinese medicine(TCM)has long been used in China as a treatment for RA and is achieving everincreasing acceptance worldwide.TCM treatments are traditionally guided by the theory of treatment based on TCM syndrome differentiation;however,they remain a matter of empirical practice relying on TCM theories and doctors’own experience,which places severe restrictions on worldwide TCM application.Nevertheless,TCM is a treasure trove for drug discovery,particularly as a treatment for complicated human conditions.The discoveries of artemisinin as a treatment for malaria and of TCM–arsenic trioxide(As2O3)combination therapy as a treatment for acute promyelocytic leukemia(APL)are excellent examples of the great value of TCM.Regarding RA treatments,many Chinese medicinal herbs and their formulas,extracts,ingredients,and even single compounds have been used in clinical applications.Several Chinese proprietary medicines(CPMs)derived from TCM formulas or herbal bioactive components,such as the controlled-release ZhengQingFengTongNing(ZQFTN)Tablets,Tripterygium Glycoside Tablets,and Total Glucosides of Peony(TGP)Capsules,have been included in the National Health Insurance Directory of China,and show comparable therapeutic efficacies to those of western chemical drugs with fewer side effects.As TCM research has advanced,particularly in the use of multidisciplinary technologies,the scientific foundations and characteristics of the use of TCM to treat RA have been revealed,and the quality of TCM treatments have been increasingly enhanced.However,TCM generally lacks sufficient clinical and laboratory data to be consistent with international standards for quality,safety,and efficacy in order to support its application worldwide.Therefore,intensive basic and clinical studies on TCM are required.In particular,investigations that use cutting-edge technologies in analytical chemistry,biology,and biomedical sciences,and the development of randomized clinical trials(RCTs)and personalized pragmatic randomized controlled trials(PPRCTs)are necessary.Researchers should also collaborate to advance TCM from empirical practice to evidence-based therapy,thus consistently promoting TCM development and globalization in a vital,beneficial,and contributable manner. | Hu-Dan Pan Yao Xiao Wan-Ying Wang Ru-Tong Ren Elaine Lai-Han Leung Liang Liu | 2019 | Engineering2019，5，5： | 12 |
| 9 | 变革与绩效:高等教育的质量保障显示文摘随着高等教育规模和数量的扩大 ,世界各国都越来越关注高等教育的绩效和质量保障 ,采用各种方法来进行质量控制。文章介绍各国的经验和做法 ,指出由于高等教育的复杂性 ,不可能只有一个质量保障的方法 ,而由于每种方法都有其缺陷 ,评价绩效和质量保障必须采用多种方法。 | Elaine El-Khawas 陈小红 | 2004 | 复旦教育论坛2004，2，3： | 11 |
| 10 | The Clock Protein CCA1 and the bZIP Transcription Factor HY5 Physically Interact to Regulate Gene Expression in Arabidopsis显示文摘生理节奏的钟调整象编码轻收获的叶绿素 A/B (Lhcb ) 的那些那样的一连串的 Arabidopsis 基因的表示蛋白质。我们以前学习了二这些 Arabidopsis genesLhcb1 *1 的倡导者, Lhcb1 *3and 识别了绑钟蛋白质的一个序列联系的生理节奏的钟 1 (CCA1 ) 。这个序列,指明的 CCA1 有约束力的地点(CBS ) ,为 phytochrome 和这些基因的生理节奏的应答是必要的。在到这个序列的靠近的最近,在那里存在被显示了在另外的调整光的植物倡导者绑 bZIP 抄写因素 HY5 的一个 G 盒子核心元素。在现在的学习,我们检验了抄写因素绑定的相互作用的重要性在 Lhcb 基因的正常生理节奏的有韵律的表示的控制的 CBS 和 G 盒子核心元素。我们的结果证明 HY5 能明确地在 Lhcb 倡导者绑 G 盒子元素并且 CCA1 能改变 HY5 的有约束力的活动。我们进一步证明 CCA1 和 HY5 罐头身体上交往并且他们能在酵母记者基因试金对抄写 synergistically 起作用。HY5 的缺席导致 Lhcb1 *1 的一个更短的时期生理节奏的表示但是不影响 CATALASE3 (CAT3 ) 的生理节奏的表示,其倡导者缺乏一个 G 盒子元素。我们的结果建议 Lhcb 倡导者上的 HY5 和 CCA1 蛋白质的那个相互作用为 Lhcb 基因的正常生理节奏的表示是必要的。 | Christos Andronis Simon Barak Stephen M. Knowles Shoji Sugano Elaine M. Tobin | 2008 | Molecular Plant2008，1，1： | 9 |
| 11 | Regulation of cytokine production during phagocytosis of apoptotic cells显示文摘自我忍耐的损失和汽车反应的淋巴细胞的扩大是汽车免疫的基础。当保证的协调过程与非病理学的结果调整了细胞质和压力反应, Apoptosis 和由吞噬细胞的 apoptotic 房间的快速的清理通常发生。在 apoptotic 房间的清理的缺点将贡献自我反应的淋巴细胞的产生,它驾驶象风湿性关节炎(RA ) 和全身的豺狼座 erythematosus (SLE ) 那样的自体免疫的混乱。cytokines (IL-12, IL-23,和 IL-27 ) 和 IL-10 的 IL-12 家庭被吞噬细胞的巨噬细胞生产并且在对病原体的有免疫力的回答期间在介绍抗原的房间(APC ) 和受动器淋巴细胞的规定起关键作用。这些 cytokines 和他们的 dysregulated 活动的不恰当的表示强烈在几自体免疫的疾病的致病被含有。由吞噬细胞的 APC 的支持 inflammatory 和反煽动性的 cytokines 的生产精巧地作为内在的机制的部分在 apoptotic 房间的摄取期间被调整阻止煽动性的自体免疫的反应。怎么导出房间的信号调整的 apoptotic cytokine 生产糟糕被理解。由我们的组的最近的研究证明由激活的巨噬细胞的 apoptotic 房间的那个吞噬作用由激活一个新奇抄写抑压者导致 IL-12 p35 基因表示的强壮的抑制,我们把它称为 GC 有约束力的蛋白质(GC-BP ) ,通过酷氨酸 dephosphorylation。我们开始也正在理解位于 apoptotic 下面的分子的机制由吞噬细胞的 IL-10 的被触发房间的生产。阐明的这些研究愿望帮助一些新奇有免疫力的规章的机制并且与潜力探索对汽车抗原的有免疫力的回答的规定为自体免疫的混乱的处理发现新治疗学的目标。 | Elaine Y Chung Sun Jung Kim Xiao Jing Ma | 2006 | Cell Research2006，16，2： | 9 |
| 12 | 普适设计和可及性设计显示文摘普适设计(universal design)是一种建筑设计的方法,它考虑了人类能力和潜能的全部范围,以及人们如何在有生之年使用建筑及产品。这一方法超出了仅仅满足规范中最低可及性要求的那些技术标准;并通过对设计加以扩展来增强不同年龄段和能力水平的男性、女性和儿童的能力。 | John P.S.Salmen Elaine Ostroff 方晓风(翻译) | 2008 | 装饰2008，，10： | 9 |
| 13 | Patients with irritable bowel syndrome-diarrhea have lower disease-specific quality of life than irritable bowel syndrome-constipation显示文摘AIM: To determine effect of irritable bowel syndrome(IBS) subtype on IBS-specific quality of life(QOL) questionnaire and its subscales.METHODS: We studied IBS patients visiting our functional gastroenterology disorder clinic at a tertiary care center of Unites States.IBS and IBS subtype were diagnosed using Rome-Ⅲ questionnaire.QOL was assessed using IBS-QOL questionnaire.IBSQOL assesses quality of life along eight subscales: dysphoria,interference with activities,body image,health worry,food avoidance,social reactions,sexual health,and effect on relationships.IBS-QOL and its subscales were both scored on a range of 0-100 with higher scores suggestive of better QOL.Results of overall IBS-QOL scores and subscale scores are expressed as means with 95%CI.We compared mean IBS-QOL score and its subscales among various IBSsubtypes.Analysis of variance(ANOVA) was used to compare the mean difference between more than two groups after controlling for age and gender.A posthoc analysis using Bonferroni correction was used only when P value for ANOVA was less than 0.05.RESULTS: Of 542 patients screened,243 had IBS as per Rome-Ⅲ criteria.IBS-mixed(IBS-M) was the most common IBS subtype(121 patients,49.8%) followed by IBS- diarrhea(IBS-D)(56 patients,23.1%),IBSconstipation(IBS-C)(54 patients,22.2%) and IBSunspecified(IBS-U)(12 patients,4.9%).Overall IBSQOL scores were significantly different among various IBS-subtypes(P = 0.01).IBS-QOL of patients with IBS-D(61.6,95%CI: 54.0-69.1) and IBS-M(63.0,95%CI: 58.1-68.0) was significantly lower than patients with IBS-C(74.5,95%CI: 66.9-82.1)(P = 0.03 and 0.02 respectively).IBS-D patients scored significantly lower than IBS-C on food avoidance(45.0,95%CI: 34.8-55.2 vs 61.1,95%CI: 50.8-71.3,P = 0.04) and interference with activity(59.6,95%CI: 51.4-67.7 vs 82.3,95%CI: 74.1-90.6,P < 0.001).IBS-M patients had more interference in their activities(61.6,95%CI: 56.3-66.9 vs 82.3,95%CI: 74.1-90.6,P = 0.001) and greater impact on their relationships(73.3,95%CI: 68.4-78.2 vs 84.7,95%CI: 77.2-92.2,P = 0.02) than IBS-C patients.Patients with IBS-M also scored significantly lower than IBS-C on food avoidance(47.2,95%CI: 40.7-53.7 vs 61.1,95%CI: 50.8-71.3,P = 0.04) and social reaction(66.1,95%CI: 61.1-71.1 vs 80.0,95%CI: 72.1-87.7,P = 0.005).CONCLUSION: IBS-D and IBS-M patients have lower IBS-QOL than IBS-C patients.Clinicians should recognize food avoidance,effects on daily activities and relationship problems in these patients. | Prashant Singh Kyle Staller Kenneth Barshop Elaine Dai Jennifer Newman Sonia Yoon Shahar Castel Braden Kuo | 2015 | World Journal of Gastroenterology2015，21，26： | 9 |
| 14 | Cancer stem cell plasticity and tumor hierarchy显示文摘The origins of the complex process of intratumoral heterogeneity have been highly debated and different cellular mechanisms have been hypothesized to account for the diversity within a tumor. The clonal evolution and cancer stem cell(CSC) models have been proposed as drivers of this heterogeneity. However, the concept of cancer stem cell plasticity and bidirectional conversion between stem and non-stem cells has added additional complexity to these highly studied paradigms and may help explain the tumor heterogeneity observed in solid tumors. The process of cancer stem cell plasticity in which cancer cel s harbor the dynamic ability of shifting from a non-CSC state to a CSC state and vice versa may be modulated by specific microenvironmental signals and cellular interactions arising in the tumor niche. In addition to promoting CSC plasticity, these interactions may contribute to the cellular transformation of tumor cells and affect response to chemotherapeutic and radiation treatments by providing CSCs protection from these agents. Herein, we review the literature in support of this dynamic CSC state, discuss the effectors of plasticity, and examine their role in the development and treatment of cancer. | Marina Carla Cabrera Robert E Hollingsworth Elaine M Hurt | 2015 | World Journal of Stem Cells2015，7，1： | 8 |
| 15 | 中国和美国强直性脊柱炎的临床比较显示文摘强直性脊柱炎(As)是一种常见的风湿性疾病,20多年来,尤其是发现本病与HLAB(?)7强相关以后,对本病的认识日渐深刻。既往认为本病在我国属于少见。 | 曾庆馀 叶士圻 James Mcguire Elaine Lambert | 1991 | 广东医学1991，12，3： | 8 |
| 16 | Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis显示文摘Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. | Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui | 2022 | Bioactive Materials2022，7，7： | 8 |
| 17 | Cellular arsenic transport pathways in mammals显示文摘Natural contamination of drinking water with arsenic results in the exposure of millions of people world-wide to unacceptable levels of this metalloid. This is a serious global health problem because arsenic is a Group 1(proven) human carcinogen and chronic exposure is known to cause skin, lung, and bladder tumors. Furthermore, arsenic exposure can result in a myriad of other adverse health effects including diseases of the cardiovascular,respiratory, neurological, reproductive, and endocrine systems. In addition to chronic environmental exposure to arsenic, arsenic trioxide is approved for the clinical treatment of acute promyelocytic leukemia, and is in clinical trials for other hematological malignancies as well as solid tumors. Considerable inter-individual variability in susceptibility to arsenic-induced disease and toxicity exists, and the reasons for such differences are incompletely understood. Transport pathways that influence the cellular uptake and export of arsenic contribute to regulating its cellular, tissue, and ultimately body levels. In the current review, membrane proteins(including phosphate transporters, aquaglyceroporin channels, solute carrier proteins, and ATP-binding cassette transporters) shown experimentally to contribute to the passage of inorganic, methylated, and/or glutathionylated arsenic species across cellular membranes are discussed. Furthermore, what is known about arsenic transporters in organs involved in absorption, distribution, and metabolism and how transport pathways contribute to arsenic elimination are described. | Barbara A.Roggenbeck Mayukh Banerjee Elaine M.Leslie | 2016 | Journal of Environmental Sciences2016，28，11： | 7 |
| 18 | STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer显示文摘Accumulated evidences have demonstrated that signal transducer and activator of transcription 3(STAT3)is a critical link between inflammation and cancer.Multiple studies have indicated that persistent activation of STAT3 in epithelial/tumor cells in inflammation-associated colorectal cancer(CRC)is associated with sphingosine-1-phosphate(S1P)receptor signaling.In inflammatory response whereby interleukin(IL)-6 production is abundant,STAT3-mediated pathways were found to promote the activation of sphingosine kinases(SphK1and SphK2)leading to the production of S1P.Reciprocally,S1P encourages the activation of STAT3 through a positive autocrine-loop signaling.The crosstalk between IL-6,STAT3 and sphingolipid regulated pathways may play an essential role in tumorigenesis and tumor progression in inflamed intestines.Therapeutics targeting both STAT3 and sphingolipid are therefore likely to contribute novel and more effective therapeutic strategies against inflammation-associated CRC. | Andrew V Nguyen Yuan-Yuan Wu Elaine Y Lin | 2014 | World Journal of Gastroenterology2014，20，30： | 7 |
| 19 | Foreign Language Reading Anxiety显示文摘 | YoshikoSaito Thomas J.Garza Elaine K.Horwitz | 2002 | The Modern Language Journal2002，，2： | 7 |
| 20 | FIXED-POINT CONTINUATION APPLIED TO COMPRESSED SENSING:IMPLEMENTATION AND NUMERICAL EXPERIMENTS显示文摘Fixed-point continuation (FPC) is an approach,based on operator-splitting and continuation,for solving minimization problems with e_1-regularization:min||x||_1 +μf(x).We investigate the application of this algorithm to compressed sensing signal recovery,inwhich f(x) = 1/2||Ax-b||_M^2,A ∈R^(m×n) and m≤n.In particular,we extend the originalalgorithm to obtain better practical results,derive appropriate choices for M and μ under agiven measurement model,and present numerical results for a variety of compressed sensingproblems.The numerical results show that the performance of our algorithm comparesfavorably with that of several recently proposed algorithms. | Elaine T.Hale | 2010 | Journal of Computational Mathematics2010，28，2： | 7 |
您所在的机构暂未开通此部分的功能，请联系管理员