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| 1 | Urogenital schistosomiasis and soiltransmitted helminthiasis(STH)in Cameroon:An epidemiological update at Barombi Mbo and Barombi Kotto crater lakes assessing prospects for intensified control interventions显示文摘Background:The crater lakes of Barombi Mbo and Barombi Kotto are well-known transmission foci of schistosomiasis and soil-transmitted helminthiasis having had several important control initiatives previously.To collect contemporary epidemiological information,a cross-sectional survey was undertaken inclusive of:signs and symptoms of disease,individual treatment histories,local water,sanitation and hygiene(WASH)-related factors and malacological surveillance,with molecular characterisation of specimens.Methods:At each lake,a community cross-sectional survey was undertaken using a combination of stool and urine parasitological sampling,and interview with pro-forma questionnaires.A total of 338 children and adults participated.Material from snail and parasite species were characterised by DNA methods.Results:Egg-patent prevalence of urogenital schistosomiasis was 8.7%at Barombi Mbo(all light-intensity infections)and 40.1%at Barombi Kotto(21.2%heavy-intensity infections).Intestinal schistosomiasis was absent.At Barombi Kotto,significantly more women reported signs and symptoms associated with female genital schistosomiasis.While there had been extensive recent improvement in WASH-related infrastructure at Barombi Mbo,water contact risk scores were higher among schistosomiasis-infected participants(P<0.001)and at Barombi Kotto in general(P<0.001).Across both lakes,mean prevalence of STH was very low(6.3%)evidencing an impressive decrease of 79.0%over the last decade;neither Strongyloides stercoralis nor Ascaris lumbricoides were found.A total of 29 freshwater sampling sites were inspected for snails,13 in Barombi Mbo and 16 in Barombi Kotto;water chemistry differed significantly(P<0.0001)between lakes for both mean pH(7.9 v.9.6)and mean conductivity(64.3μS v.202.1μS)respectively.Only two Bulinus camerunensis found on the central island of Barombi Kotto were observed to shed schistosome cercariae,but schistosome DNA was later detected in Bulinus sampled from both lakes as well as in Indoplanorbis exustus,an invasive species from Asia.Conclusions:STH is currently at very low levels while urogenital schistosomiasis is of greatest concern at Barombi Kotto.This assessment highlights a unique opportunity for further study of the epidemiological dynamics at these crater lakes,to evaluate future intensified interventions both in terms of gaining and sustaining control at Barombi Kotto or in moving towards local interruption of transmission of both diseases at Barombi Mbo. | Suzy J.Campbell J.Russell Stothard Faye O’Halloran Deborah Sankey Timothy Durant Dieudonne Eloundou Ombede Gwladys Djomkam Chuinteu Bonnie LWebster Lucas Cunningham EJames LaCourse Louis-Albert Tchuem-Tchuente | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 2 | Intestinal schistosomiasis in Uganda at high altitude(>1400 m):malacological and epidemiological surveys on Mount Elgon and in Fort Portal crater lakes reveal extra preventive chemotherapy needs显示文摘Background:Intestinal schistosomiasis is of public health importance in Uganda but communities living above 1400 m are not targeted for control as natural transmission is thought unlikely.To assess altitudinal boundaries and at-risk populations,conjoint malacological and epidemiological surveys were undertaken on Mount Elgon(1139 m-3937 m),in Fort Portal crater lakes and in the Rwenzori Mountains(1123 m-4050 m).Methods:Seventy freshwater habitats[Mount Elgon(37),Fort Portal crater lakes(23),Rwenzori Mountains(8)and Lake Albert(2)]were inspected for Biomphalaria species.Water temperature,pH and conductivity were recorded.A parasitological examination of 756 schoolchildren[Mount Elgon(300),Fort Portal crater lakes(456)]by faecal microscopy of duplicate Kato-Katz smears from two consecutive stool samples was bolstered by antigen(urine-CCA dipstick)and antibody(SEA-ELISA)diagnostic assays.Results:Biomphalaria spp.was found up to 1951 m on Mount Elgon and 1567 m in the Fort Portal crater lakes.Although no snail from Mount Elgon shed cercariae,molecular analysis judged 7.1%of snails sampled at altitudes above 1400 m as having DNA of Schistosoma mansoni;in Fort Portal crater lakes three snails shed schistosome cercariae.Prevalence of intestinal schistosomiasis as measured in schoolchildren by Kato-Katz(Mount Elgon=5.3%v.Fort Portal crater lakes=10.7%),CCA urine-dipsticks(18.3%v.34.4%)and SEA-ELISA(42.3%v.63.7%)showed negative associations with increasing altitude with some evidence of infection up to 2000 m.Conclusions:Contrary to expectations,these surveys clearly show that natural transmission of intestinal schistosomiasis occurs above 1400 m,possibly extending up to 2000 m.Using spatial epidemiological predictions,this now places some extra six million people at-risk,denoting an expansion of preventive chemotherapy needs in Uganda. | Michelle CStanton Moses Adriko Moses Arinaitwe Alison Howell Juliet Davies Gillian Allison EJames LaCourse Edridah Muheki Narcis BKabatereine J.Russell Stothard | 2017 | Infectious Diseases of Poverty2017，6，1： | 3 |
| 3 | Randomised double blind trial of intravenous diltazem versus Glyceryl trinitrate for unstable angina pectoris显示文摘 | EJAM Gobel | 1995 | The Lancet1995，346，3： | 1 |
| 4 | Surgical treatment of acute and chronic acromioclavicular dislocation Tossy type III and V using the Hook plate显示文摘 | Ejam S Lind T Falkenberg B | 2008 | Acta Orthopaedica Belgica2008，74，4： | 1 |
| 5 | Effects of complex training on explosive strength in adolescent male basketball players 显示文摘 | Santos EJAM and Janeira MAAS | 2008 | J Strength Cond Res2008，22，： | 1 |
| 6 | Surgical treatment of acute and chronic acromioclavicular dislocation Tossy type 111 mad V using the Hook plate显示文摘 | Ejam S Lind T Falkenberg B | 2008 | Acta Orthop Belg2008，74，4： | 1 |
| 7 | Surgical treatment of acute and chronic acromioclavicular dislocation Tossy type III and V using the Hookplate显示文摘 | Ejam S Lind T Falkenberg B | | 0，，： | 1 |
| 8 | Randomized double blind trial of intravenous diltazem versus Glyceryl trinitrate for unstable angina pectoris 显示文摘 | EJAM Gobel | 1995 | Lancet1995，346，： | 1 |
| 9 | Surgical treatment of acute and chronic acromioclavicular dislocation Tossy type In and V using the Hook plate显示文摘 | Ejam S Lind T Falkenberg B | 2008 | Acta Orthop Belg2008，74，4： | 1 |
| 10 | Surgical treatment of a- cute and chronic acromioclavicular dislocation Tossy type Ⅲ and V using the Hook plate 显示文摘 | Ejam S Lind T Falkenberg B | 2008 | Acta Orthop Belg2008，74，4： | 1 |
| 11 | Surgical treatment of acute and chronic acromioclavicular dislocation Tossy type ill and V using the Hook plate显示文摘 | Ejam S Lind T Falkenberg B | 2008 | Acta Orthop Belg2008，74，： | 1 |
| 12 | Surgical treatment of acute and chronic acromioclavicular dislocation Tossy type Ⅲ and V using the Hook plate显示文摘 | Ejam S Lind T Falkenberg B | | 0，，04： | 1 |
| 13 | Preparation and characterization of poly(d,l-lactic-co-glycolic acid) mi- crospheres containing desferrioxamine 显示文摘 | SCHLICHER EJAM POSTMA NS ZUIDEMA J | 1997 | lnt J Pharm1997，153，： | 1 |
| 14 | Long term follow-up after early intervention with intravenous diltiazem or intravenous nitro glycerin for unstable angina pectoris显示文摘 | Gilst WHV Kam PJD | 1998 | Eur heart J1998，19，： | 1 |
| 15 | Random ised double blind trial of intravenous diltazem versus Glyceryl trinitrate for unstable angina pectoris显示文摘 | | 1995 | The Lancet1995，346，： | 1 |
| 16 | α-Synuclein arginylation in the human brain显示文摘Background: Alpha-synuclein (α-syn) exhibits pathological misfolding in many human neurodegenerative disorders. We previously showed that α-syn is arginylated in the mouse brain and that lack of arginylation leads to neurodegen-eration in mice. Methods: Here, we tested α-syn arginylation in human brain pathology using newly derived antibodies in combina-tion with Western blotting, biochemical assays, and experiments in live neurons. Results: We found that α-syn was arginylated in the human brain on E46 and E83, two sites previously implicated in α-syn pathology and familial cases of Parkinson’s disease. The levels of arginylation in different brain samples ranged between ~ 3% and ~ 50% of the total α-syn pool, and this arginylation nearly exclusively concentrated in the subcellu-lar α-syn fraction that sedimented at low centrifugation speeds and appeared to be simultaneously targeted by multi-ple posttranslational modifications. Arginylated α-syn was less susceptible to S129 phosphorylation and pathological aggregation in neurons. The arginylation level inversely correlated with the overall α-syn levels and with patient age, suggesting a possible causal relationship between arginylation decline and α-syn-dependent neuropathology. Conclusion: We propose that α-syn arginylation constitutes a potential neuroprotective mechanism that prevents its abnormal accumulation during neurodegeneration and aging in the human brain. | Jun Zhao Buyan Pan Marie Fina Yun Huang Marie Shimogawa Kelvin C.Luk Elizabeth Rhoades EJames Petersson Dawei W.Dong Anna Kashina | 2022 | Translational Neurodegeneration2022，11，1： | 0 |
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