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| 1 | Approach to the endoscopic resection of duodenal lesions显示文摘Duodenal polyps or lesions are uncommonly found on upper endoscopy. Duodenal lesions can be categorized as subepithelial or mucosally-based, and the type of lesion often dictates the work-up and possible therapeutic options. Subepithelial lesions that can arise in the duodenum include lipomas, gastrointestinal stromal tumors, and carcinoids. Endoscopic ultrasonography with fine needle aspiration is useful in the characterization and diagnosis of subepithelial lesions. Duodenal gastrointestinal stromal tumors and large or multifocal carcinoids are best managed by surgical resection. Brunner's gland tumors, solitary Peutz-Jeghers polyps, and non-ampullary and ampullary adenomas are mucosally-based duodenal lesions, which can require removal and are typically amenable to endoscopic resection. Several anatomic characteristics of the duodenum make endoscopic resection of duodenal lesions challenging. However, advanced endoscopic techniques exist that enable the resection of large mucosally-based duodenal lesions. Endoscopic papillectomy is not without risk, but this procedure can effectively resect ampullary adenomas and allows patients to avoid surgery, which typically involves pancreaticoduodenectomy. Endoscopic mucosal resection and its variations(such as cap-assisted, cap-band-assisted, and underwater techniques) enable the safe and effective resection of most duodenal adenomas. Endoscopic submucosal dissection is possible but very difficult to safely perform in the duodenum. | Jonathan P Gaspar Edward B Stelow Andrew Y Wang | 2016 | World Journal of Gastroenterology2016，22，2： | 17 |
| 2 | Gastric intestinal metaplasia is associated with gastric dysplasia but is inversely correlated with esophageal dysplasia显示文摘AIM To determine which clinical factors might be associated with gastric intestinal metaplasia(IM) in a North American population.METHODS Pathology and endoscopy databases at an academicmedical center were reviewed to identify patients with and without gastric IM on biopsies for a retrospective cohort study. Patient demographics, insurance status, and other clinical factors were reviewed.RESULTS Four hundred and sixty-eight patients with gastric IM(mean age: 61.0 years ± 14.4 years, 55.5% female) and 171 without gastric IM(mean age: 48.8 years ± 20.8 years, 55.0% female) were compared. The endoscopic appearance of atrophic gastritis correlated with finding gastric IM on histopathology(OR = 2.05, P = 0.051). Gastric IM was associated with histologic findings of chronic gastritis(OR = 2.56, P < 0.001), gastric ulcer(OR = 6.97, P = 0.015), gastric dysplasia(OR = 6.11, P = 0.038), and gastric cancer(OR = 6.53, P = 0.027). Histologic findings of Barrett's esophagus(OR = 0.28, P = 0.003) and esophageal dysplasia(OR = 0.11, P = 0.014) were inversely associated with gastric IM. Tobacco use(OR = 1.73, P = 0.005) was associated with gastric IM.CONCLUSION Patients who smoke or have the endoscopic finding of atrophic gastritis are more likely to have gastric IM and should have screening gastric biopsies during esophagogastroduodenoscopy(EGD). Patients with gastric IM are at increased risk for having gastric dysplasia and cancer, and surveillance EGD with gastric biopsies in these patients might be reasonable. | Justin M Gomez James T Patrie Wissam Bleibel Jeanetta W Frye Bryan G Sauer Vanessa M Shami Edward B Stelow Christopher A Moskaluk Andrew Y Wang | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 3 |
| 3 | Tracking domestic ducks:A novel approach for documenting poultry market chains in the context of avian influenza transmission显示文摘Agro-ecological conditions associated with the spread and persistence of highly pathogenic avian influenza(HPAI) are not well understood, but the trade of live poultry is suspected to be a major pathway. Although market chains of live bird trade have been studied through indirect means including interviews and questionnaires, direct methods have not been used to identify movements of individual poultry. To bridge the knowledge gap on quantitative movement and transportation of poultry, we introduced a novel approach for applying telemetry to document domestic duck movements from source farms at Poyang Lake, China. We deployed recently developed transmitters that record Global Positioning System(GPS) locations and send them through the Groupe Spécial Mobile(GSM) cellular telephone system. For the first time, we were able to track individually marked ducks from 3 to 396 km from their origin to other farms, distribution facilities, or live bird markets. Our proof of concept test showed that the use of GPS-GSM transmitters may provide direct, quantitative information to document the movement of poultry and reveal their market chains. Our findings provide an initial indication of the complexity of source-market network connectivity and highlight the great potential for futuretelemetry studies in poultry network analyses. | Chang-Yong Choi John Y Takekawa XIONG Yue LIU Ying Martin Wikelski George Heine Diann J Prosser Scott H Newman John Edwards Fusheng Guo Xiangming Xiao | 2016 | Journal of Integrative Agriculture2016，15，7： | 3 |
| 4 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 5 | A segmentation algorithm for noisy images: design and evaluation显示文摘 | Xu Y Olman V Edward C U | 1998 | Pattern Recognition Letters1998，19，13： | 1 |
| 6 | A new technique for measuring the mechanical properties of thin films 显示文摘 | Shape W N Bin Y Edwards R L | 1997 | Journal of Microelectromech System1997，，6： | 1 |
| 7 | The holocene asian monsoon: links to solar changes and North Atlantic climate 显示文摘 | Wang Y J Cheng H Edwards R L | 2005 | Science2005，308，： | 1 |
| 8 | Terahertz Pulsed Imaging in Vivo: Measurements andProcessing Methods 显示文摘 | Parrott Edward P J Sy Stanley M Y Blu Thierry | 2011 | Journal of Biomedical Optics(S1083-3668)2011，16，10： | 1 |
| 9 | CLIC4 regulates TGF-]3- dependent myofibroblast differentiation to produce a cancer stroma显示文摘 | Shukla A Edwards R Yang Y | 2014 | Oncogene2014，33，7： | 1 |
| 10 | Millennial-and orbital-scale changes in the East Asian monsoon over the past 224,000 years显示文摘 | Cheng H Edwards R | 2008 | Nature2008，451，： | 1 |
| 11 | National Healthcare Safety Network(NHSN)report:data summary for 2006through 2008,issued December 2009显示文摘 | Edwards JR Peterson KD Mu Y | 2009 | Am J Infect Control2009，37，10： | 1 |
| 12 | The Holocene Asian Monsoon: links to solar changes and North Atlantic climate显示文摘 | Wang Y J Cheng H Edwards R L | 2005 | Science2005，308，： | 1 |
| 13 | Thermal chondroplasty with bipolar and monopolar radiofrequency energy: effect of treatment time on chondrocyte death and surface contouring 显示文摘 | LU Y EDWARDS RB 3RD NHO S | 2002 | Arthroscopy2002，18，7： | 1 |
| 14 | Influence of residual stress on bonding strength and fracture of plasma-sprayed hydroxyapatite coatings on Ti-6Al-4V substrfate显示文摘 | Yang Y C Chang Edward | 2001 | Biomaterials2001，22，： | 1 |
| 15 | The Holocene Asian mon- soon: links to solar changes and North Atlantic climate显示文摘 | Wang Y J Cheng H Edwards R L | 2005 | Science2005，308，5723： | 1 |
| 16 | Representing moving images with layers显示文摘 | John Y A Wang Edward H Adelson | 1994 | IEEE Transactions on Image Processing1994，3，62： | 1 |
| 17 | A high-resolution absolute-dated Late Pleistocene monsoon record from Hulu Cave,China显示文摘 | Wang Y J Cheng H Edwards R L | 2001 | Science2001，294，： | 1 |
| 18 | National Health- care Safety Network (NHSN) report: datasummary for 2006 through 2008,issue December 2009显示文摘 | Edwards JR Peterson KD MU Y | 2009 | Ami Infect Control2009，37，10： | 1 |
| 19 | Gene overexpression/suppression analysis of candidate virulence factors of Candida albicans 显示文摘 | Fu Y Luo G Spellberg BJ Edwards JE Jr Ibrahim AS | 2008 | Eukaryot Cell2008，7，3： | 1 |
| 20 | Improvements in 230Th dating, 230Th and 254U half-life values, and U Th isotopic measurements by multi--collector inductively coupled plasma mass spectroscopy 显示文摘 | Cheng H Edwards R L Shen C C Po Asrnerom Y Woodhed J Hellstrom J Wang Y Kon6 X Spotl C Wang X Alexander Jr E C | 2013 | Earth and Planetary Science Letters2013，3713，72： | 1 |
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