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| 1 | Burden of onchocerciasis-associated epilepsy:first estimates and research priorities显示文摘Background:Since the 1990s,evidence has accumulated of an increased prevalence of epilepsy in onchocerciasisendemic areas in Africa as compared to onchocerciasis-free areas.Although the causal relationship between onchocerciasis and epilepsy has yet to be proven,there is likely an association.Here we discuss the need for disease burden estimates of onchocerciasis-associated epilepsy(OAE),provide them,detail how such estimates should be refined,and discuss the socioeconomic impact of OAE,including a cost-estimate for anti-epileptic drugs.Main body:Providing OAE burden estimates may aid prevention of epilepsy in onchocerciasis-endemic areas by inciting and informing collaboration between onchocerciasis control programmes and mental health services.Epilepsy not only massively impacts the health of those affected,but it also carries a high socioeconomic burden for the households and communities involved.We used previously published geospatial estimates of onchocerciasis in Africa and a separately published logistic regression model quantifying the association between onchocerciasis and epilepsy to estimate the number of OAE cases.We then applied disability weights for epilepsy to quantify the burden in terms of years of life lived with disability(YLD)and estimate the cost of treatment.We estimate that in 2015 roughly 117000 people were affected by OAE across onchocerciasis-endemic areas previously under the African Programme for Onchocerciases control(APOC)mandate where OAE has ever been reported or suspected,and another 264000 persons in onchocerciasis-endemic areas where OAE has never been investigated before.The total number of YLDs due to OAE was 39300 and 88700 in these areas respectively,based on a weighted mean disability weight of 0.336.The burden of OAE is approximately 13%of the total YLDs attributable to onchocerciasis and 10%of total YLDs attributable to epilepsy.We estimated that by 2015 the total costs of treatment with antiepileptic drug for OAE cases would have been a minimum of 12.4 million US$.Conclusions:These estimates suggest a considerable health,social and economic burden of OAE in Africa.The treatment and care for people with epilepsy,especially in hyperendemic onchocerciasis areas with high epilepsy prevalence thus requires more financial and human resources. | Natalie V.S.Vinkeles Melchers Sarah Mollenkopf Robert Colebunders Michael Edlinger Luc E.Coffeng Julia Irani Tresor Zola Joseph N.Siewe Sake Jde Vlas Andrea S.Winkler Wilma A.Stolk | 2018 | Infectious Diseases of Poverty2018，7，1： | 3 |
| 2 | Application of FEM to coupled-electric, thermal and mechanical problem 显示文摘 | Preis K Biro O Dyczij R Edlinger | 1994 | IEEE Transactions on Magnetics1994，30，5： | 1 |
| 3 | Clopidogrel pretreatment is associated with reduced in-hospital mortality in primary percutaneous coronary intervention for acute ST- elevation myocardial infarction 显示文摘 | DORLER J EDLINGER M ALBER H F | 2011 | Eur Heart J2011，32，23： | 1 |
| 4 | Computed tomography guided percutaneous lung biopsies and sus- pected fungal infections in pediatric cancer patients 显示文摘 | Kropshofer G Kneer A Edlinger M | 2014 | Pediatr Blood Cancer2014，5，1： | 1 |
| 5 | Total serum cholesterol and cancer incidence in the Metabolic syndrome and Cancer Project(Me-Can)显示文摘 | Strohmaier S Edlinger M Manjer J | 2013 | PLo S One2013，8，54： | 1 |
| 6 | Association of human herpesvirus 6 infection with drug reaction with eosinophilia and systemic symptoms 显示文摘 | Descamps V Valance A Edlinger C | 2001 | Arch Dermatol2001，137，3： | 1 |
| 7 | Finite element a-nalysis of elastoplastic indentation: application to hard coatings显示文摘 | Montmitonnet P Edlinger M L Felder E | 1993 | ASME Journal of Triology1993，115，1： | 1 |
| 8 | Clopidogrel pre-treatment is associated with reduced in-hospital mortality in primary percutaneous coronary intervention for acute ST-elevation myocardial infarction显示文摘 | Drler J Edlinger M Alber HF | 2011 | Eur Heart J2011，32，23： | 1 |
| 9 | Computedtomography guided percutaneous lung biopsies and suspected fungal infections in pediatric cancer patients 显示文摘 | Kropshofer G Kneer A Edlinger M | 2014 | Pediatr Blood Cancer2014，6，9： | 1 |
| 10 | Comparison of risk for ear- ly-onset sepsis in small-for-gestational-age neonates and appropriate-for-gestational-age neonates based on lower levels of white blood cell, neutrophil, and platelet counts 显示文摘 | Hofer N Edlinger S Resch g | 2014 | Pediatr Neonatol2014，55，4： | 1 |
| 11 | Finite-element analysis of arbitrarily shaped cavity resonators using H1 (curl) elements 显示文摘 | Perepelitsa S G Edlinger R D Lee J F | 1997 | IEEE Transactions on Magnetics1997，33，2： | 1 |
| 12 | A hybrid brain-computer in-terface for smart home control显示文摘 | Edlinger G Holzner C Guger C | | 0，，： | 1 |
| 13 | Patient outcomes in schizophrenia : Correlates with sociodemographic variables, psycho- pathology, and side effects显示文摘 | Hofer A Baumgartner S Edlinger M | 2005 | Eur Psychiatry-2005，20，： | 1 |
| 14 | Neutrophil impairment associated with iron therapy in hemodialysis patients with functional iron deficiency显示文摘 | Patruta SI Edlinger R Sunder-Plassmann G | 1998 | J Am Soc Nephrol1998，9，： | 1 |
| 15 | Association of human herpesvirus 6 infection with drug reaction with eosinophilia and systemic symptoms显示文摘 | Descamps V Valance A Edlinger C | 2001 | Arch Dermatol2001，137，3： | 1 |
| 16 | Compari- son of the prevalence of human papilloma virus infection in histopathologically confirmed premalignant oral lesions and healthy oral mucosa by brush smear detection显示文摘 | Dalla Torre D Burtscher D Edlinger M | 2015 | O- ral Surg Oral Med Oral Pathol Oral Radiol2015，119，3： | 1 |
| 17 | Intracardiac echoand reduced radiocontrast requirements during TAVR 显示文摘 | Bartel T Bonaros N Edlinger M | 2014 | JACC Cardiovasc Imaging2014，7，3： | 1 |
| 18 | How many people are able to operate an EEG-based brain-computer interface BCI显示文摘 | C Guger G Edlinger W Harkam | 2003 | IEEE Transaction on Neural Systems and Rehabilitation Engineering2003，11，2： | 1 |
| 19 | On the existence of different types of central beta rhythms below 30 Hz 显示文摘 | Pfurtschener G Stancak A Edlinger G | 1997 | Eleetroencephalography and Clinical Neurophyslology1997，102，4： | 1 |
| 20 | Modelling the evolution of a bipartite network—Peer referral in interlocking directorates显示文摘 | Johan Koskinen Christofer Edling | 2010 | Social Networks2010，，3： | 1 |
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