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2篇 您的检索式：作者名="Edgar R.Kramer"

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		题名	作者	年代	出处	被引量
	1	The neuroprotective and regenerative potential of parkin and GDNF/Ret signaling in the midbrain dopaminergic system显示文摘Parkinson’s disease(PD)is the second most common neurodegenerative disease after Alzheimer’s disease.The etiology of PD is still not completely understood,but the degeneration of dopaminergic(DA)neurons in the substantia nigra pars compacta(SNpc),loss of DA innervation of the striatum,and protein aggregates in the form of Lewy bodies and neurites	Edgar R.Kramer	2015	Neural Regeneration Research2015，10，11：	2
	2	Is activation of GDNF/RET signaling the answer for successful treatment of Parkinson's disease?A discussion of data from the culture dish to the clinic显示文摘The neurotrophic signaling of glial cell line-derived neurotrophic factor(GDNF)with its canonical receptor,the receptor tyrosine kinase RET,coupled together with the GDNF family receptor alpha 1 is important for dopaminergic neuron survival and physiology in cell culture experiments and animal models.This prompted the idea to try GDNF/RET signaling as a therapeutic approach to treat Parkinson’s disease with the hallmark of dopaminergic cell death in the substantia nigra of the midbrain.Despite several clinical trials with GDNF in Parkinson’s disease patients,which mainly focused on optimizing the GDNF delivery technique,benefits were only seen in a few patients.In general,the endpoints did not show significant improvements.This suggests that it will be helpful to learn more about the basic biology of this fascinating but complicated GDNF/RET signaling system in the dopaminergic midbrain and about recent developments in the field to facilitate its use in the clinic.Here we will refer to the latest publications and point out important open questions in the field.	James A.Conway Edgar R.Kramer	2022	Neural Regeneration Research2022，17，7：	0

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