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| 1 | Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis显示文摘AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark Agouti rats(n = 8/group) were gavaged daily(1 mL) with water, high-dose RE(HDR; 200 mg/kg) or low-dose RE(LDR; 20mg/kg) for eight days. Intestinal mucositis was induced(day 5) with 5-FU(150 mg/kg) via intraperitoneal injection. Intestinal tissue samples were collected for myeloperoxidase(MPO) activity and histological examination. Xenopus oocytes expressing aquaporin 4 water channels were prepared to examine the effect of aqueous RE on cell volume, indicating a potential mechanism responsible for modulating net fluid absorption and secretion in the gastrointestinal tract. Statistical significance was assumed at P < 0.05 by one-way ANOVA. RESULTS B o d y w e i g h t w a s s i g n i f i c a n t l y r e d u c e d i n r a t s administered 5-FU compared to healthy controls(P < 0.01). Rats administered 5-FU significantly increased intestinal MPO levels(≥ 307%; P < 0.001), compared to healthy controls. However, LDR attenuated this effect in 5-FU treated rats, significantly decreasing ileal MPO activity(by 45%; P < 0.05), as compared to 5-FU controls. 5-FU significantly reduced intestinal mucosal thickness(by ≥ 29% P < 0.001) as compared to healthy controls. LDR significantly increased ileal mucosal thickness in 5-FU treated rats(19%; P < 0.05) relative to 5-FU controls. In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure. As water efflux was unaltered by the presence of extracellular RE, the directional flow of water across the epithelial barrier, in the presence of extracellular RE, indicated that RE may alleviate water loss across the epithelial barrier and promote intestinal health in chemotherapy-induced intestinal mucositis.CONCLUSION In summary, low dose RE improves selected parameters of mucosal integrity and reduces ileal inflammation, manifesting from 5-FU-induced intestinal mucositis. | Juliana E Bajic Georgina L Eden Lorrinne S Lampton Ker Y Cheah Kerry A Lymn Jinxin V Pei Andrea J Yool Gordon S Howarth | 2016 | World Journal of Gastroenterology2016，22，37： | 3 |
| 2 | Strategy in emerging economies 显示文摘 | Hoskisson R E Eden L Lau C M Wright M | 2000 | Academy of Management Journal2000，43，3： | 1 |
| 3 | The E2F - regulated gene Chkl is highly expressed in triple - negative estrogen receptor - / progesterone receptor -/HER - 2 - breast carcinomas 显示文摘 | Vedinden L Bempt IV Eden G | 2007 | Cancer Res2007，67，14： | 1 |
| 4 | Cloning of cDNA encoding the sweet-tasting plant protein thaumatin and its expression in Escher&hia coli 显示文摘 | Edens L Heslinga L Klock R | 1982 | Gene1982，18，： | 1 |
| 5 | The endurance of metals显示文摘 | EDEN E M ROSE W N CUNNINGHAM F L | 1911 | Proceedings of the Institution of Mechanical Engineers1911，81，4： | 1 |
| 6 | Stem cell and growth factor based regen-erative therapies for avascular necrosis of the femoral head显示文摘 | RACKWITZ E EDEN L REPPENHAGEN S | 2012 | Stem Cell Res Ther2012，3，1： | 1 |
| 7 | Cloning of cDNA encoding the sweet tasting plant protein thaumatin and its expression in Escherichia coli 显示文摘 | Heslinga L Klok R | 1982 | Gene1982，18，： | 1 |
| 8 | alpha,25-Dihydroxyvitamin D3-induced down-regulation of the checkpoint proteins,Chk1 and Claspin,is mediated by the pocket proteins p107 and p130显示文摘 | Verlinden L Eden G Van Hellemont R | 2007 | J Steroid Biochem Mol Biol2007，103，35： | 1 |
| 9 | Governance in multilateral R&D alliances 显示文摘 | Li D Eden L Hitt M A | 2011 | Organization Science2011，23，4： | 1 |
| 10 | Is there a liability of localness? How emerging market firms respond to regulatory punctua- tions显示文摘 | Perez-Batres L A Eden L | 2008 | Journal of International Management2008，14，3： | 1 |
| 11 | Biomechanical comparison of the Locking Compression superior anterior clavicle plate with seven and ten hole reconstruction plates in midshaft clavicle fracture stabilization显示文摘 | Eden L Doht S Frey SP | | 0，，12： | 1 |
| 12 | Battery management systems in electric and hybrid vehicles显示文摘 | Xing Yinjiao Eden W M Tsui K L | 2011 | Energies2011，4，12： | 1 |
| 13 | Biomeehanical comparison of the locking compres- sion superior anterior clavicle plate with seven and ten hole recon- struction plates in midshaft clavicle fracture stabilisation 显示文摘 | Eden L Doht S | 2012 | lnt Or- thop2012，12，： | 1 |
| 14 | Parent-offspring aggression in moorhens 显示文摘 | Hom A G and Eden S F | 1988 | Behav Ecol Sociobiol1988，23，： | 1 |
| 15 | Experi- mental determination of scanning probe microscope canti- lever spring constants utilizing a nanoindentation appara- tus 显示文摘 | HOLBERY J D EDEN V L SARIKAYA M | 2000 | Review of Scientific Instruments2000，71，10： | 1 |
| 16 | Friends, acquaintances, or strangers? Partner selection in R&D alliances显示文摘 | Li D Eden L Hitt M A | 2005 | Academy of Management Journal2005，51，2： | 1 |
| 17 | Strat- egy in Emerging Economies显示文摘 | HOSKISSON R E EDEN L LAU C M | 2000 | Academy of Manage- ment Journal2000，43，3： | 1 |
| 18 | Friends, acquaintances, or strangers? Partner selection in R&D alliances 显示文摘 | Li D Eden L Hitt MA | 2008 | Academy of Management Journal2008，51，2： | 1 |
| 19 | Spray Cooling Thermal Management for Increased Device Reliability 显示文摘 | Cader T Westra L J Eden R C | 2004 | IEEE Transactions on Device and Materials Reliability2004，4，60： | 1 |
| 20 | Strategy in emerging economies 显示文摘 | Hoskisson R E Eden L Lau C M Wright M | 2000 | Academy of Management Journal2000，45，3： | 1 |
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