|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Roles of micro RNA-140 in stem cell-associated early stage breast cancer显示文摘An increasing body of evidence supports a stepwise model for progression of breast cancer from ductal carcinoma in situ(DCIS) to invasive ductal carcinoma(IDC). Due to the high level of DCIS heterogeneity, we cannot currently predict which patients are at highest risk for disease recurrence or progression. The mechanisms of progression are still largely unknown, however cancer stem cell populations in DCIS lesions may serve as malignant precursor cells intimately involved in progression. While genetic and epigenetic alterations found in DCIS are often shared by IDC, m RNA and mi RNA expression profiles are significantly altered. Therapeutic targeting of cancer stem cell pathways and differentially expressed mi RNA could have significant clinical benefit. As tumor grade increases, mi RNA-140 is progressively downregulated. mi R-140 plays an important tumor suppressive role in the Wnt, SOX2 and SOX9 stem cell regulator pathways. Downregulation of mi R-140 removes inhibition of these pathways, leading to higher cancer stem cell populations and breast cancer progression. mi R-140 downregulation is mediated through both an estrogen response element in the mi R-140 promoter region and differential methylation of Cp G islands. These mechanisms are novel targets for epigenetic therapy to activate tumor suppressor signaling via mi R-140. Additionally, we briefly explored the emerging role of exosomes in mediating intercellular mi R-140 signaling. The purpose of this review is to examine the cancer stem cell signaling pathways involved in breast cancer progression, and the role of dysregulation of mi R-140 in regulating DCIS to IDC transition. | Benjamin Wolfson Gabriel Eades Qun Zhou | 2014 | World Journal of Stem Cells2014，6，5： | 11 |
| 2 | Long non-coding RNAs in stem cells and cancer显示文摘An overwhelming majority of the transcribed genome encodes for non-coding RNA(ncR NA) sequences. Deep sequencing of the transcriptome has uncovered tens of thousands of long ncR NA(lncR NA) sequences. However, little is known regarding the possible functions for a vast majority of these sequences. Among those lncR NAs whose function has been experimentally validated, most serve as regulators of gene expression. LncR NAs have been found to be critical to development and homeostasis and they have been implicated in several pathologies including cancer. Here, we examine the functions and underlying mechanisms of lnc RNAs in stem cells and in cancer biology, areas linked by the actions of lncR NAs. | Gabriel Eades Yong-Shu Zhang Qing-Lin Li Ji-Xiang Xia Yuan Yao Qun Zhou | 2014 | World Journal of Clinical Oncology2014，5，2： | 10 |
| 3 | Adipocyte activation of cancer stem cell signaling in breast cancer显示文摘Signaling within the tumor microenvironment has a critical role in cancer initiation and progression. Adipocytes, one of the major components of the breast microenvironment,have been shown to provide pro-tumorigenic signals that promote cancer cell proliferation and invasiveness in vitro and tumorigenicity in vivo. Adipocyte secreted factors such as leptin and interleukin-6(IL-6) have a paracrine effect on breast cancer cells. In adipocyte-adjacent breast cancer cells, the leptin and IL-6 signaling pathways activate janus kinase 2/signal transducer and activatorof transcription 5, promoting the epithelial-mesenchymal transition, and upregulating stemness regulators such as Notch, Wnt and the Sex determining region Y-box 2/octamer binding transcription factor 4/Nanog signaling axis. In this review we will summarize the major signaling pathways that regulate cancer stem cells in breast cancer and describe the effects that adipocyte secreted IL-6 and leptin have on breast cancer stem cell signaling. Finally we will introduce a new potential treatment paradigm of inhibiting the adipocyte-breast cancer cell signaling via targeting the IL-6 or leptin pathways. | Benjamin Wolfson Gabriel Eades Qun Zhou | 2015 | World Journal of Biological Chemistry2015，6，2： | 6 |
| 4 | Algorithms for drawing graphs: an annotated bibliography 显示文摘 | BATTISTA G D EADES P TAMASSIA R | 1994 | Computational Geometry: Theory and Applications1994，4，5： | 1 |
| 5 | A heuristic for graph drawing显示文摘 | EADES P | 1984 | Congressus Nutnerantiunt1984，，42： | 1 |
| 6 | The effects ofmorphine-and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog显示文摘 | Martin WR Eades CG Thompson JA | 1976 | J Pharmacol Exp Ther1976，197，3： | 1 |
| 7 | Turbulent openchannel flow in circular corru gated culverts显示文摘 | Ead S A Rajaratnam N Katopodis C | | 0，，10： | 1 |
| 8 | miR-200a regulates Nrf2 activation by targeting Keapl mRNA in breast cancer cells显示文摘 | Eades G Yang M Yao Y | 2011 | J Biol Chem2011，286，40： | 1 |
| 9 | Railway vehicle internal noise显示文摘 | EADE P W HARDY A E J | 1977 | Journal of Sound and Vibration1977，51，3： | 1 |
| 10 | On Interpreting Security Returns During the Ex - dividend Period 显示文摘 | Eades K Hess P Kim E | 1984 | Journal of Financial Economics1984，13，： | 1 |
| 11 | On Interpreting Security Returns During the Ex-Dividend Period显示文摘 | EADES K M HESS P J KIM E H | | 0，，： | 1 |
| 12 | Turbidity-Controlled Suspended Sediment Sampling显示文摘 | Lewis J Eads R | 1996 | Water Resources Research1996，32，7： | 1 |
| 13 | Epigenetic patterns in the progression of esophageal adenocarcinoma显示文摘 | Eads CA Lord RV Wickramasinghe K | 2001 | Cancer Res2001，61，8： | 1 |
| 14 | Primary cutaneous adenoid cystic carcinoma:a case report and review of the literature显示文摘 | Salzman MJ Eades E | 1991 | Plast Reconstr Surg1991，88，： | 1 |
| 15 | Intrahepatic cholestasis of pregnancy: a critical revie w显示文摘 | Palmer DG Eads J | 2000 | J Perinatai Nurs2000，14，： | 1 |
| 16 | Intranepatic cholestasis of pregnancy crit ical review显示文摘 | Palmer DG Eads J | 2000 | J Perinat Neonatal Nurs2000，14，： | 1 |
| 17 | Interregional brain interactions in children with unilateral hearing loss显示文摘 | Tibbetts K Ead B Umansky A | 2011 | Otolaryngol Head Neck Surg2011，14，4： | 1 |
| 18 | A quick test to determine lime requirement for lime stabilization显示文摘 | EADES J L GRIM R E | 1966 | Highway Research Record National Research Council1966，139，： | 1 |
| 19 | Straight-line drawing algorithms for hierarchical graphs and clustered graphs 显示文摘 | EADES P FENG Q W | 1997 | Comput- er Science1997，，1190： | 1 |
| 20 | MethyLight: A high-throughput assay to measure DNA methylation 显示文摘 | Eads C A Danenberg K D Kawakami K | 2000 | Nucleic Acids Res2000，28，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员