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| 1 | Simulation of cemented granular materials, II: Micromechanical description and strength mobilization at the onset of macroscopic yielding显示文摘 | ESTRADA N LIZCANO A | 2010 | Physical Review E2010，82，01： | 1 |
| 2 | Temperature related distribution of Lucifer typus (Crustacea:Decapoda) in the Gulf of California显示文摘 | Hendrickx M E Estrada N F D | 1994 | Rev Biol Trop1994，，42： | 1 |
| 3 | Communicability in complex networks显示文摘 | Estrada E Hatano N | 2008 | Physical Review E2008，77，03： | 1 |
| 4 | Decellularized liver ma trix as a carrier for the transplantation of human fetal and pri- mary hepatocytes in mice 显示文摘 | Zhou P Lessa N Estrada DC | 2011 | laver Transpl2011，17，： | 1 |
| 5 | Extension of edge connectivity index Relationships to line graph indices and QSPR applications 显示文摘 | ESTRADA E GUEVARA N GUTMAN I | 1998 | Journal of Chemical Information and Modeling1998，38，3： | 1 |
| 6 | Carbaz- de-based cyano-stilbene highly fluorescent microcrys- tats显示文摘 | Upamall K A N Estrada L A De P K et 01 | 2011 | Langrauir2011，27，5： | 1 |
| 7 | Neutralization of venom-induced hemorrhage by equine antibodies raised by immunization with a plasmid encoding a novel P-II metalloproteinase from the lancehead pitviper Bothrops asper显示文摘 | Viviana Arce-Estrada Gabriela Azofeifa-Cordero Ricardo Estrada Alberto Alape-Girón Marietta Flores-Díaz | 2008 | Vaccine2008，，3： | 1 |
| 8 | Predicting trophic position in sharks of the north-west Atlantic Ocean using stable isotope analysis显示文摘 | Rice A N Lutcavage M E | 2003 | J Mar Biol Assoc UK2003，83，： | 1 |
| 9 | Grouth,structure and optical characterization of high quality ZnO thin films obtained by spray pyrolysis显示文摘 | PARAGUAY F D ESTRADA W L ACOSTA D R N | 1999 | Thin Solid Films1999，350，12： | 1 |
| 10 | Clinical and Serologic Response to the 23-valent Polysaccharide Pneumococcal Vaccine in Children and Teens with Recurrent Upper Respiratory Tract Infections and Selective Antibody Deficiency显示文摘 | Estrada J Najera M Pounds N | 2016 | Pediatr Infect Dis J2016，35，2： | 1 |
| 11 | Clinical and serologic response to the 23-valent polysaccharide pneumococcal vaccine in children and teens with recurrent upper respiratory tract infections and selective antibody deficiency显示文摘 | Estrada J Najera M Pounds N | 2016 | Pediatr Infect Dis J2016，35，2： | 1 |
| 12 | Growth, structure and optical characterization of high quality ZnO thin films obtained by spray pyrolysis显示文摘 | Paraguay F D Estrada W L Acosta D R N | 1999 | Thin Solid Films1999，350，12： | 1 |
| 13 | Communicability in Complex Networks显示文摘 | Estrada E Hatano N | 2008 | Physical Review E2008，77，3： | 1 |
| 14 | Temperature related distribution of Lucifer typus ( Crustacea: Decapoda) in the Gulf of Caifomia 显示文摘 | Hendrickx M E Estrada N F D | 1994 | Rev Biol Trop1994，，42： | 1 |
| 15 | Whole Body Vibration Exposure for MH-60S Pilots 显示文摘 | Harrer K L Yniguez D Majar M Ellenbecker D Estrada N Geiger M | 2006 | STAR (S1548-8837)2006，14，44： | 1 |
| 16 | Topological atomic displ-acements,Kirchhoff and Wiener indices of molecules显示文摘 | ESTRADA E HATANO N | 2010 | Chemical Physics Letters2010，486，1： | 1 |
| 17 | Designing sedative/hypnotic compounds from a novel substructural graph-theoretical approach显示文摘 | Ernesto Estrada Alfredo Pe?a Ramón García-Domenech | 1998 | Journal of Computer - Aided Molecular Design1998，，6： | 1 |
| 18 | The physics of communicability in complex networks显示文摘 | Estrada E Hatano N Benzi M | 2012 | Phys Rep2012，514，3： | 1 |
| 19 | Growth, structure and optical characterization of high quality ZnO thin films obtained by spray pyrolysis显示文摘 | Paraguay F D Estrada W L Acosta D R N | 1999 | Thin Solid Films1999，350，： | 1 |
| 20 | Clinicopathological differences,risk factors and prognostic scores for western patients with intestinal and diffuse-type gastric cancer显示文摘BACKGROUND In the molecular era,the Laurén system is still a cost-effective and widely implemented classification for gastric cancer(GC)and it has been recently associated with clinical,histological and molecular features of these tumors.Despite recent advances in the understanding of the molecular biology of GC,there is a need to develop new prognostic tools for patient stratification in clinical practice.Thus,the identification of easily available prognostic factors in patients with intestinal and diffuse-type tumors can significantly improve risk assessment and patient stratification in GC.AIM To identify clinicopathological differences,risk factors,and to develop costeffective prognostic scores for patients with intestinal and diffuse-type GC.METHODS Retrospective study of all patients undergoing surgery for GC at a tertiary referral center from 2001 to 2019.286 cases met inclusion criteria(intestinal:190,diffuse:96).Clinical data and gross findings were collected.All specimens were reviewed by two independent pathologists and a detailed protocol for histologic evaluation was followed.Five tissue microarrays(TMAs)were constructed and sections of the TMA block were immunostained for HERCEPTEST,MSH2,MSH6,MLH1 and PMS2.Statistical analyses were performed and prognostic scores were developed based on hazard ratios.RESULTS Intestinal and diffuse-type GC showed different epidemiological,clinicopathological and prognostic features.Diffuse tumors were significantly associated with younger age,less symptomatology,flat morphology,deeper invasion,perineural infiltration,advanced stage at diagnosis,administration of adjuvant therapy and poorer prognosis.Intestinal lesions were fungoid or polypoid,showed necrosis,desmoplasia,microsatellite instability and HERCEPTEST positivity and were diagnosed at earlier stages.Tumor depth,desmoplasia,macroscopic type and lymph node involvement were independently related to the Laurén subtype.Furthermore,intestinal and diffuse GC were associated with different risk factors for progression and death.Vascular invasion,perineural infiltration and growth pattern were important prognostic factors in intestinal-type GC.On the contrary,tumor size and necrosis were significant prognosticators in diffuse-type GC.Our recurrence and cancer-specific death scores for patients with intestinal and diffuse-type GC showed an excellent patient stratification into three(diffuse GC)or four(intestinal)prognostic groups.CONCLUSION Our findings support that Laurén subtypes represent different clinicopathological and biological entities.The development of specific prognostic scores is a useful and cost-effective strategy to improve risk assessment in GC. | Cristina Díaz del Arco Lourdes Estrada Muñoz Luis Ortega Medina Elena Molina Roldán MÁngeles Cerón Nieto Soledad García Gómez de las Heras M Jesús Fernández Aceñero | 2022 | World Journal of Gastrointestinal Oncology2022，14，6： | 1 |
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