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| 1 | Demand and supply integration: a conceptual framework of value creation through knowledge management显示文摘 | Esper L Ellinger A E Stank T P | 2010 | Journal of the Academy of Marketing Science2010，38，1： | 1 |
| 2 | Demand and supply integration:a conceptual framework of value creation through knowledge management显示文摘 | Esper T L Ellinger A E Stank T P | 2010 | Journal of the Academy of Marketing Science2010，38，1： | 1 |
| 3 | The electronicsupply chain:its impact on the current and future structure ofstrategic alliances,partnerships and logistics leadership显示文摘 | WILLIAMS L R ESPER T L OZMENT J | 2002 | International Journal of Physical Distribution&Logistics Man-agement2002，32，8： | 1 |
| 4 | The value of collaborative transportation management (CTM) : Its relationship to CPFR and information technology 显示文摘 | Esper T L Williams L R | 2003 | Transportation Journal2003，42，4： | 1 |
| 5 | Effect of temperature on the superplastic characteristics of a powder metallurgy pure aluminum 显示文摘 | Kojima S Esperance G L | 1996 | Scripta Materialia1996，35，10： | 1 |
| 6 | Supply Chain Management and Its Relationship to Logistics, Marketing, Production, and Operations Management显示文摘 | MENTZER J T STANK T P ESPER T L | 2008 | Journal of Business Logistics2008，29，1： | 1 |
| 7 | Demand and supply integration: A conceptual framework of value creation through knowledge management显示文摘 | Esper T L Ellinger A E Stank T P | 2010 | Journal of the Academy of Marketing Science2010，38，1： | 1 |
| 8 | The last mile:an examination of effects of online retail delivery strategies on consumers显示文摘 | Esper T L Jensen T D Turnipseed F L | 2003 | Journal of Business Logistics2003，24，2： | 1 |
| 9 | Logistics Learning Capability: Sustaining the Competitive Ad- vantage Gained through Logistics Leverage显示文摘 | Esper T L Fugate B S Davis-Sramek B | 2007 | Jour nal of Business Logistics2007，28，2： | 1 |
| 10 | Tensile properties of a 2014 aluminum alloy in the temperature range 250 to 500℃显示文摘 | Loretto M H Roberts W T | 1984 | Metallurgical Transactions A1984，15，5： | 1 |
| 11 | The value of collaborative transportation management (CTM): Its relationship to CPFR and information technology显示文摘 | Esper T L Williams L R | 2003 | Transportation Journal2003，42，4： | 1 |
| 12 | The value of collaborative transportation management (CTM) : Its relationship to CPFR and infor?mation technology显示文摘 | Esper T L Williams L R | 2003 | TransportationJournal2003，42，4： | 1 |
| 13 | 查看详情显示文摘 | T Imai G L'Esperance B D Hong | | 0，，： | 1 |
| 14 | 查看详情显示文摘 | T Imai S Kojima G L'Esperance | | 0，，： | 1 |
| 15 | Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C显示文摘AIM To characterize the role of apolipoprotein B100(apoB 100) in hepatitis C viral(HCV) infection. METHODS In this study, we utilize a gene editing tool, transcription activator-like effector nucleases(TALENs), to generate human hepatoma cells with a stable genetic deletion of APOB to assess of apoB in HCV. Using infectious cell culture-competent HCV, viral pseudoparticles, replicon models, and lipidomic analysis we determined the contribution of apoB to each step of the viral lifecycle. We further studied the effect of mipomersen, an FDAapproved antisense inhibitor of apoB 100, on HCV using in vitro cell-culture competent HCV and determined itsimpact on viral infectivity with the TCID50 method. RESULTS We found that apo B100 is indispensable for HCV infection. Using the JFH-1 fully infectious cell-culture competent virus in Huh 7 hepatoma cells with TALENmediated gene deletion of apoB(APOB KO), we found a significant reduction in HCV RNA and protein levels following infection. Pseudoparticle and replicon models demonstrated that apo B did not play a role in HCV entry or replication. However, the virus produced by APOB KO cells had significantly diminished infectivity as measured by the TCID-50 method compared to wildtype virus. Lipidomic analysis demonstrated that these virions have a fundamentally altered lipidome, with complete depletion of cholesterol esters. We further demonstrate that inhibition of apoB using mipomersen, an FDA-approved anti-sense oligonucleotide, results in a potent anti-HCV effect and significantly reduces the infectivity of the virus. CONCLUSION Apo B is required for the generation of fully infectious HCV virions, and inhibition of apo B with mipomersen blocks HCV. Targeting lipid metabolic pathways to impair viral infectivity represents a novel host targeted strategy to inhibit HCV. | Esperance AK Schaefer James Meixiong Christina Mark Amy Deik Daniel L Motola Dahlene Fusco Andrew Yang Cynthia Brisac Shadi Salloum Wenyu Lin Clary B Clish Lee F Peng Raymond T Chung | 2016 | World Journal of Gastroenterology2016，22，45： | 1 |
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