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| 1 | Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions显示文摘AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic diseases.METHODS Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow cytometry.Serum levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by ELISA.RESULTS Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other groups.Inactive p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC patients.There was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC patients.There was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC. | Abdel-Rahman N Zekri Somaya El Deeb Abeer A Bahnassy Abeer M Badr Mona S Abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa Abd Elkader | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 2 | Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children显示文摘AIM: To identify the prevalence, risk factors and manifestations of asymptomatic hepatitis C virus (HCV) infection in Egyptian children. METHODS: Children at the age of 1-9 years were screened for HCV antibodies and alanine aminotransferase (ALT) levels. Every child with elevated ALT and/or detectable HCV antibodies was tested for HCV RNA by RT-PCR and compared with two negative controls for risk factors and signs and symptoms of liver disease.RESULTS: We screened 1042 children, six of them had elevated ALT, negative HCV antibody and positive RNA, likely representing acute hepatitis C cases. Fifteen children were HCV seropositive, 5 of them were HCV RNA positive. Asymptomatic HCV infection was present in 2.02% (positive results for either HCV antibodies or HCV-RNA or both). Symptoms such as diarrhea, abdominal pain, history of fatigue and school absence because of illness and risk factors such as dental care were significantly more common among HCV positive cases than among controls. None of the HCV positive children was diagnosed as having signs of advanced liver disease upon clinical or ultrasonographic examination. CONCLUSION: Asymptomatic HCV infection is detectable in 2.02% Egyptian children. | MS El-Raziky M El-Hawary G Esmat AM Abouzied N El-Koofy N Mohsen S Mansour A Shaheen M Abdel Hamid H El-Karaksy | 2007 | World Journal of Gastroenterology2007，13，12： | 4 |
| 3 | When prone position is contraindicatedor not preferable, can supine perculaneous nephrolithotomy solve the problem 显示文摘 | Youssef A Esmat M Wael M | 2012 | International Brazilian Journal of Urology2012，38，1： | 1 |
| 4 | in vivo and in vitro studies on the antioxidant activity of aloin compared to doxorubicin in rats显示文摘 | ESMAT A Y SAID M M HAMDY G M | 2012 | Drug Development Research2012，73，3： | 1 |
| 5 | Health-related quality of life in Egyptian patients after liver transplanta- tion显示文摘 | Mabrouk M Esmat G Yosry A | 2012 | Ann Hepatol2012，11，6： | 1 |
| 6 | Suggested mechanisms of ac-tion of UVA phototherapy in morphea : a molecular study 显示文摘 | EI-Mofty M Mostafa W Esmat S | 2004 | Photo-dermatol Photoimmunol Photomed2004，20，： | 1 |
| 7 | Quantitative and qualitative evaluation of bio-aerosols in surgery rooms and emergency department of an educational hospital显示文摘 | RAMAZAN M ESMAT S MAZHAR I Q | 2014 | Jundishapur J Microbiol2014，7，11： | 1 |
| 8 | Surgical and functional outcomes of sigmoid vaginoplasty among patients with variants of disorders of sex development 显示文摘 | Nowier A Esmat M Hamza RT | 2012 | Int Braz J Urol2012，38，： | 1 |
| 9 | When prone position is contraindicated or not preferable, can supine percutaneous neph- rotithotomy solve the problem? 显示文摘 | Youssef A Esmat hi Wael M | 2012 | Int Braz J Urol2012，38，： | 1 |
| 10 | Recurrence of hepatitis C virus (genotype 4) infection after living-donor liver transplant in Egyptian patients显示文摘 | Yosry A Abdel-Rahman M Esmat G | 2009 | Exp Clin Transplant2009，7，： | 1 |
| 11 | Is a raised CA 19-9 level diagnosticfor a cholangiocarcinoma in patients with no history ofsclerosing cholangitis?显示文摘 | John A R Haghighi K S Taniere P Esmat M E Tan YM BramhalI S R | 2006 | Dig Surg2006，23，56： | 1 |
| 12 | Narrow band Ultraviolet B 311 nm in the treatment of vitiligo: two right-left comparison studies 显示文摘 | El Mofty M Mostafa W Esmat S | 2006 | Photodermatol Photoimmunol Photomed2006，22，： | 1 |
| 13 | When prone position is contraindicated or not preferable, can supine percutaneous nephrolithotomy solve the problem显示文摘 | Youssef A Esmat M Wael M | 2012 | Int BrazJ Urol2012，38，1： | 1 |
| 14 | Efficacy of Bacillus thuringiensis cryl4 toxin against root knot nematode, Meloidogynejavaniea显示文摘 | Sareh B R Esmat M M | 2015 | Plant Protect Science2015，51，1： | 1 |
| 15 | When prone position is contraindicated or not preferable, can supine percutaneous nephrolithotomy solve the problem?显示文摘 | Youssef A Esmat M Wael M | 2012 | Int Braz J Urol2012，38，1： | 1 |
| 16 | Risk factors for bleedingand clinical implications in patients undergoing liver trans- plantation显示文摘 | Esmat Gamil M Pirenne J Van Malenstein H | 2012 | Transplant Proc2012，44，9： | 1 |
| 17 | Effect of chro-rnium supplementation on the diabetes induced-oxidative stress in liver and brain of adult rats 显示文摘 | Refaie F M Esmat A Y Mohamed A F | 2009 | Biometals2009，22，： | 1 |
| 18 | The antihyperlipidemic activities of 4 (3H)quianzolinone and two halogenated derivatives in rats 显示文摘 | F M Refaie A Y Esmat S M Gawad | 2005 | Lipids Health Dis2005，，4： | 1 |
| 19 | Roleof Helicobacter pylori in patients with HCV - relatedchronichepatitis and cirrhosis with or without hepatocellular carci-noma :possible association with disease progression 显示文摘 | Esmat G El - Bendary M Zakarya S Ela MA Zalata K | 2012 | J ViralHepat2012，19，7： | 1 |
| 20 | Narrow band Ultraviolet B 311 nm in the treatment of vitiligo : two right-left comparison studies 显示文摘 | El Mofty M Mostafa W Esmat S | 2006 | Photodermatol Photoimmunol Photomed2006，22，1： | 1 |
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