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| 1 | 小柴胡汤对鼠实验性肝纤维化的影响显示文摘为探讨小柴胡汤对鼠肝纤维化的抑制作用,腹腔分别注射二甲基亚硝基胺和猪血清复制两种肝纤维化动物模型。预防和治疗性投与小柴胡汤可促进肝维生素A含量恢复,降低肝胶原含量和明显抑制肝前α-Ⅰ型胶原的基因表达。同时免疫组化染色证实小柴胡杨可显著减少Ⅰ、Ⅲ型胶原在肝脏沉积和明显减少α-平滑肌原纤维阳性的伊东细胞(ItoCell)的数目。结果显示小柴胡汤可防治鼠肝纤维化的发生与发展。 | 马跃荣 Ichiro Shimizu Susumu Ito Yoko Mizobuchi Mitugi Yasuda Ever Escobar | 1997 | 泸州医学院学报1997，20，2： | 7 |
| 2 | The Strawberry Fruit Fra a Allergen Functions in Flavonoid Biosynthesis显示文摘1 变应原是的草莓兄弟主要桦树花粉变应原的一个相当或相同的事物赌了 v 1。当变异的遗传型的白水果,被知道被过敏症影响的个人容忍,缺乏它时,它被 Fragaria x ananassa 的红成熟水果综合。Proteomic 分析显示出 1 是的那个兄弟在与 anthocyanin 颜料小径的酶一起的容忍的白水果的遗传型下面调整。在这研究,我们报导三个兄弟的空间、时间的表示一编码不同 isoforms 的基因,和兄弟的短暂调停 RNAi 的 silencing 一在有 ihpRNA 的红水果的栽培变种 Elsanta 的草莓水果的基因构造。作为兄弟的减少的层次的后果 mRNAs,水果被获得那生产了 anthocyanins 和在上游的代谢物的显著地减少的层次。这效果与本氨基丙酸氨 lyase (FaPAL ) 的平行下面规定一致,到 chalcone synthase (FaCHS ) 的更小的程度,抄本层次也在这些水果发现。在 F 的自然地发生的白水果的遗传型。chiloensis 和 F。vesca,一个抄本铺平的兄弟比红水果的变化的那些高,可能在这些变异的遗传型补偿 FaPAL 和 FaCHS 的低表示层次。结果表明那个兄弟表情直接被连接到 flavonoid 生合成和表演变应原有的兄弟在在草莓的颜料形成的必要生物功能水果。 | Cristina Munoz Thomas Hoffmann Nieves Medina Escobar Felix Ludemann Miguel A. Botella Victoriano Valpuesta Wilfried Schwab | 2010 | Molecular Plant2010，3，1： | 6 |
| 3 | Diagnosis of interatrial block显示文摘 | Antoni Bay, s de Luna Adrian Baranchuk Luis Alberto Escobar Robledo Albert Masso van Roessel Manuel Martinez-Selles | 2017 | Journal of Geriatric Cardiology2017，14，3： | 6 |
| 4 | T_3-induced liver AMP-activated protein kinase signaling:Redox dependency and upregulation of downstream targets显示文摘AIM:To investigate the redox dependency and promotion of downstream targets in thyroid hormone(T3)-induced AMP-activated protein kinase(AMPK)signaling as cellular energy sensor to limit metabolic stresses in the liver.METHODS:Fed male Sprague-Dawley rats were given a single ip dose of 0.1 mg T3/kg or T3 vehicle(Na OH0.1 N;controls)and studied at 8 or 24 h after treatment.Separate groups of animals received 500 mg N-acetylcysteine(NAC)/kg or saline ip 30 min prior T3.Measurements included plasma and liver 8-isoprostane and serumβ-hydroxybutyrate levels(ELISA),hepaticlevels of m RNAs(q PCR),proteins(Western blot),and phosphorylated AMPK(ELISA).RESULTS:T3 upregulates AMPK signaling,including the upstream kinases Ca2+-calmodulin-dependent protein kinase kinase-βand transforming growth factor-β-activated kinase-1,with T3-induced reactive oxygen species having a causal role due to its suppression by pretreatment with the antioxidant NAC.Accordingly,AMPK targets acetyl-Co A carboxylase and cyclic AMP response element binding protein are phosphorylated,with the concomitant carnitine palmitoyltransferase-1α(CPT-1α)activation and higher expression of peroxisome proliferator-activated receptor-γco-activator-1αand that of the fatty acid oxidation(FAO)-related enzymes CPT-1α,acyl-Co A oxidase 1,and acylCo A thioesterase 2.Under these conditions,T3 induced a significant increase in the serum levels ofβ-hydroxybutyrate,a surrogate marker for hepatic FAO.CONCLUSION:T3 administration activates liver AMPK signaling in a redox-dependent manner,leading to FAO enhancement as evidenced by the consequent ketogenic response,which may constitute a key molecular mechanism regulating energy dynamics to support T3preconditioning against ischemia-reperfusion injury. | Luis A Videla Virginia Fernández Pamela Cornejo Romina Vargas Paula Morales Juan Ceballo Alvaro Fischer Nicolás Escudero Oscar Escobar | 2014 | World Journal of Gastroenterology2014，20，46： | 3 |
| 5 | Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies显示文摘膝关节骨性关节炎(OA)是世界上最常见的关节炎,其发病率逐年上升。不断上涨的治疗费用给患者带来了经济负担。膝关节OA治疗的两个早期干预目标是减轻膝关节的疼痛和关节软骨的损害。目前用于治疗膝关节OA的方法虽取得了一定疗效,但仍没有一种方法可达到全膝关节置换术(TKA)的治疗效果。TKA主要应用于治疗末期膝关节OA,其缺点是有手术侵入性和手术费用昂贵。因而,应该重视创新性的再生技术,以推迟甚至消除患者对TKA的需求。一些基于生物材料和细胞的疗法目前正处于发展阶段,并已在临床前和临床研究方面取得了初步进展。单独或联合应用先进的生物材料和干细胞治疗膝关节OA可减轻疼痛,使损害的关节软骨再生。在此综述中,我们讨论了膝关节OA疼痛和软骨损害的发病机制,并探讨了该病的最新治疗策略及其局限性。 | Jorge L. Escobar Ivirico Maumita Bhattacharjee Emmanuel Kuyinu Lakshmi S. Nair Cato T. Laurencin | 2017 | Engineering2017，3，1： | 3 |
| 6 | 完全性结肠无神经节细胞症的长期转归:32年回顾 | Escobar M.A. Grosfeld J.L. West K.W. 郭战宏 | 2005 | 世界核心医学期刊文摘(儿科学分册)2005，0，12： | 2 |
| 7 | Protein phosphatases and chromatin modifying complexes in the inflammatory cascade in acute pancreatitis显示文摘Acute pancreatitis is an inflammation of the pancreas that may lead to systemic inflammatory response syndrome and death due to multiple organ failure. Acinar cells, together with leukocytes, trigger the inflammatory cascade in response to local damage of the pancreas. Amplification of the inflammatory cascade requires up-regulation of proinflammatory cytokines and this process is mediated not only by nuclear factor κB but also by chromatinmodifying complexes and chromatin remodeling. Among the different families of histone acetyltransferases, the p300/CBP family seems to be particularly associated with the inflammatory process. cAMP activates gene expression via the cAMP-responsive element (CRE) and the transcription factor CRE-binding protein (CREB). CREB can be phosphorylated and activated by different kinases, such as protein kinase A and MAPK, and then it recruits the histone acetyltransferase co-activator CREB-binding protein (CBP) and its homologue p300. The recruitment of CBP/p300 and changes in the level of histone acetylation are required for transcription activation. Transcriptional repression is also a dynamic and essential mechanism of down-regulation of genes for resolution of inflammation, which seems to be mediated mainly by protein phosphatases (PP1, PP2A and MKP1) and histone deacetylases(HDACs) .Class HDACs are key transcriptional regulators whose activities are controlled via phosphorylationdependent nucleo/cytoplasmic shuttling. PP2A is responsible for dephosphorylation of class HDACs, triggeringnuclear localization and repression of target genes, whereas phosphorylation triggers cytoplasmic localization leading to activation of target genes. The potential benefit from treatment with phosphodiesterase inhibitors and histone deacetylase inhibitors is discussed. | Javier Escobar Javier Pereda Alessandro Arduini Juan Sastre Juan Sandoval Luis Aparisi Gerardo López-Rodas Luis Sabater | 2010 | World Journal of Gastrointestinal Pharmacology and Therapeutics2010，1，3： | 2 |
| 8 | Two strawberry miR159 family members display developmental‐specific expression patterns in the fruit receptacle and cooperatively regulate Fa‐GAMYB显示文摘 | FabianaCsukasi LiviaDonaire AnaCasa?al LlúciaMartínez‐Priego Miguel A.Botella NievesMedina‐Escobar CésarLlave VictorianoValpuesta | 2012 | New Phytologist2012，，1： | 2 |
| 9 | H∞position transfer and regulation for floating offshore wind turbines显示文摘This paper proposes H∞controller design for platform position transfer and regulation of floating offshore wind turbines.The platform movability of floating wind turbines can be utilized in mitigating the wake effect in the wind farm,thereby maximizing the wind farm's total power capture and efficiency.The controller is designed so that aerodynamic force is adjusted to meet the three objectives simultaneously,that is,1)to generate the desired electrical power level,2)to achieve the desired platform position,and 3)to suppress the platform oscillation.To acquire sufficient aerodynamic force to move the heavy platform,the pitch-to-stall blade pitching strategy is taken instead of the commonly-used pitch-to-feather strategy.The desired power level is attained by the standard constant-power strategy for the generator torque,while Hstate-feedback control of blade pitch and nacelle yaw angles is adopted for the position regulation and platform oscillation suppression.Weighting constants for the H∞controller design are adjusted to take the trade-off between the position regulation accuracy and the platform motion reduction.To demonstrate the efficiency of the proposed controler,a virtual 5-MW semi-submersible wind turbine is considered.Simulation results show that the designed H∞controller successfully accomplishes the platform position transfer and regulation as well as the platform oscillation reduction against wind and wave disturbances,and that it outperforms a previously-proposed linear quadratic controller with an integrator. | Eduardo Eribert ESCOBAR AQUINO Ryozo NAGAMUNE | 2020 | Control Theory and Technology2020，18，3： | 2 |
| 10 | Accelerated degradation tests:Modeling and analysis显示文摘 | Meeker W Q Escobar L A Lu C J | 1998 | Technometrics1998，40，： | 1 |
| 11 | Influence of nanofiltration on distribution system biostability显示文摘 | Escobar I Randall A | 1999 | AWWA1999，91，6： | 1 |
| 12 | A nonopioid analgesic acts upon the PAG-RVM axis to reverse inflammatory hyperalgesia 显示文摘 | Vazquez E Escobar W Ramirez K | 2007 | Europ J Neuro Sci2007，25，2： | 1 |
| 13 | Growth of CrN,films by DC reactive magnetron sputtering at constant N2/Ar gas flow显示文摘 | Forniés E Escobar Galindo R Sánchez O | 2006 | Surface & Coatings Technology2006，200，： | 1 |
| 14 | Mammary ductoscopy:current status and future prospects显示文摘 | Mokbel K Escobar PF Matsunaga T | 2005 | Eur J Surg Oncol2005，31，1： | 1 |
| 15 | High-throughput viral expression of cDNA-green fluorescent protein fusions reveals novel subcellular addresses and identifies unique proteins that interact with plasmodesmata 显示文摘 | ESCOBAR N M HAUPT S THOW G | 2003 | The Plant Cell2003，15，： | 1 |
| 16 | Action recognition with a bio-inspired feedforward Spiking Networks显示文摘 | Escobar M J Kornprobst P | 2009 | Int J Ccomput Vis2009，82，： | 1 |
| 17 | High-throughput viral expression of cDNA-green fluorescent protein fusions reveals novel subcellular addresses and identifies unique proteins that interact with plasmodesmata显示文摘 | Escobar N M Haupt S Thow G | 2003 | Plant Cell2003，15，： | 1 |
| 18 | Long- term outcomes in patients with stage Ⅳ neuroblastoma 显示文摘 | Escobar MA Grosfeld JL Powell RL | 2006 | J Pediatr Surg2006，41，2： | 1 |
| 19 | Emerging roles of ehemokines in prostate eaneer 显示文摘 | Vindrieux DI Escobar P Lazennec G | 2009 | Endocr Relat Caneer2009，16，3： | 1 |
| 20 | Oral N-carbamylglu- tamate supplementation inereases protein synthesis in skeletal muscle of piglets显示文摘 | Frank J W Escobar J Nguyen H V | 2007 | J Nutr2007，137，2： | 1 |
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