|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Implications of Klotho in vascular health and disease显示文摘Cardiovascular disease(CVD) is a prevalent condition in general population and the first cause of death overall. Klotho, a pleiotropic protein related to longevity that acts as a co-receptor of the fibroblast growth factor 23, has been proposed as a key regulator of the development of CVD. In the few clinical studies made, it has been observed a relationship between low levels of soluble Klotho and the occurrence and severity of CVD, as well as a reduction of cardiovascular risk when they are high. Also, different polymorphisms of human Klotho gene have been related to the incidence of cardiovascular events. Moreover, several experimental studies indicate that this protein acts in the maintenance of vascular homeostasis. Klotho improves endothelial dysfunction through promotion of NO production and mediates antiinflammatory and anti-aging effects such as suppression of adhesion molecules expression, attenuation of nuclear factor-kappa B or inhibition of Wnt signaling. Furthermore,this protein is related to the attenuation of vascular calcification as well as prevention of cardiac hypertrophy. The expression of this protein in the vascular wall implies a new scenario for the treatment of vascular disorders. The purpose of this review is to provide an overview of the relationship between the Klotho protein and CVD, in addition to its role in the maintenance of functional vascular integrity. | Ernesto Martín-Núez Javier Donate-Correa Mercedes Muros-de-Fuentes Carmen Mora-Fernández Juan F Navarro-González | 2014 | World Journal of Cardiology2014，6，12： | 4 |
| 2 | Klotho in cardiovascular disease:Current and future perspectives显示文摘Protein Klotho,beyond its role as a regulator of the phosphatemia,is also involved in the maintaining of the cardiovascular health,being associated its alterations with the development of cardiovascular damage and increased morbi-mortality. For all this,nowadays Klotho is the subject of a thorough research which is focused on uncover its intimate mechanisms of action,and in analyzing the utility of its modulation as a potential strategy with clinical applicability. Molecular mechanisms of Klotho are not well understood but an emerging research area links Klotho deficiency with vascular pathology. Changes in this protein have been associated with cardiovascular-related complications like inflammation,vascular calcification,and endothelial dysfunction. All this is particularly relevant if considering the recent discovery of Klotho expression in vascular tissue. | Javier Donate-Correa Ernesto Martin-Nunez Carmen Mora-Fernandez Mercedes Muros-de-Fuentes Nayra Perez-Delgado Juan F Navarro-Gonzalez | 2015 | World Journal of Biological Chemistry2015，6，4： | 4 |
| 3 | An operating system extension for a multiprocessor显示文摘 | Ernesto F V Martins | 1998 | Journal of Systems Architecture1998，45，5： | 1 |
| 4 | Comprehensive approach to modeling and simulation of photovohaic arrays 显示文摘 | MARCELO G V JONAS R G ERNESTO R F | 2009 | IEEE Transactions on Power Electronics2009，24，5： | 1 |
| 5 | Modeling and simulation of lithium-ion batteries 显示文摘 | ERNESTO M R RUBEN V M ANTONIO F T | 2011 | Computers and Chemical Engineering2011，35，1： | 1 |
| 6 | Comprehensive approach to modeling and simulation of photovoltaic arrays显示文摘 | Marcelo G V Jonas R G Ernesto R F | 2009 | IEEE transactions on power electronics2009，24，5： | 1 |
| 7 | A mild and easy one-pot procedure for the synthesis of 2-deoxy-sugars from glycols显示文摘 | VALERIA C CONCETTA I ERNESTO F | 2000 | Tetrahedron Letters2000，41，： | 1 |
| 8 | A Biosynthetically Significant New Bacterio-Hopanoid Present in Large Amounts in the Caribbean Sponge Plakortis Simplex显示文摘 | Valeria C Ernesto F | 2001 | Tetrahedron2001，57，10： | 1 |
| 9 | Advantages of fungal enzyme production in solid state over liquid fermentation systems 显示文摘 | GUSTAVO V G ERNESTO F T CRISTOBAL N A | 2003 | J Biochem Eng2003，13，： | 1 |
| 10 | Emulating nurse plants to restore oak forests 显示文摘 | ERNESTO I B OMAR R S JOEL F | 2011 | Ecological Engineering2011，37，8： | 1 |
| 11 | Comprehen-sive Approach to Modeling and Simulation of Photovoltaic Arrays显示文摘 | MARCELO G V JONAS R G ERNESTO R F | 2009 | IEEE Transactions on Power Electronics2009，24，5： | 1 |
| 12 | Two novel pyrrole-imidazole alkaloids from the Mediterranean sponge Agelas oroides 显示文摘 | Ernesto F Orazio TS | 2000 | Tetrahedron Letters2000，41，： | 1 |
| 13 | Advantages of fungal enzyme production in solid state over liquid fermentation systems 显示文摘 | GUSTAVO V G ERNESTO F T CRISTOBAL N A | 2003 | Biochem Eng J2003，13，： | 1 |
| 14 | Dissectionof the pathway of molecular recognition by calmodulin 显示文摘 | JAMES K K PETER F F ERNESTO J F | 2002 | Biochemistry2002，41，8： | 1 |
| 15 | Adaptive inhibitors of HIV-1 protease显示文摘 | HIROYASU O ERNESTO F | 2005 | Prog Biophys Mol Biol2005，88，2： | 1 |
| 16 | Imaging techniques for assessing hepatic fat content in nonalcoholic fatty liver disease 显示文摘 | Ernesto R V Rafael F Manuel M L | 2008 | Annals of Hepatology2008，7，3： | 1 |
| 17 | Compre-hensive approach to modeling and simulation ofphotovoltaic arrays 显示文摘 | Marcelo G Y Jonas R G Ernesto R F | 2009 | IEEE Transactions onPower Electronics2009，24，5： | 1 |
| 18 | Toward semantics-aware manage- ment of intellectual property rights显示文摘 | Ernesto D Cristiano F | | 0，，： | 1 |
| 19 | Analysis and Simulation of the P&O MPPT Algorithm Using a Linearized PV Array Models显示文摘 | Marcelo G Villalva Ernesto Ruppert F | | 0，，11： | 1 |
| 20 | Comprehensive approach tomodeling and simulation of photovoltaic arrays显示文摘 | Marcelo G V Jonas R G Ernesto R F | 2009 | IEEE Transactions onPower Electronics2009，24，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员