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| 1 | Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats显示文摘AIM:To investigate the effects of long term pretreatment with low-,medium-and high-dose aspirin(acetylsalicylic acid,ASA) on a model of acute pancreatitis(AP) induced in rats.METHODS:Forty male Wistar rats were used.Three experimental groups,each consisting of eight animals,received low-(5 mg/kg per day),medium-(150 mg/kg per day) and high-dose(350 mg/kg per day) ASA in supplemented pellet chow for 100 d.Eight animals,serving as the AP-control group,and another eight,serving as reference value(RV) group,were fed with standard pellet chow for the same period.After pretreatment,AP was induced in the experimental animals by intraperitoneal administration of cerulein(2 × 50 μg/kg),while the RV group received saline in the same way.Twelve hours after the second injection,the animals were sacrificed.Pancreatic tissue and plasma samples were collected.One part of the collected pancreatic tissues was used for histopathological evaluation,and the remaining portion was homogenized.Cytokine levels [tumor necrosis factor,interleukin(IL)1β,IL-6],hemogram parameters,biochemical parameters(amylase and lipase),nuclear factor-κB,aspirin triggered lipoxins and parameters related to the antioxidant system(malondialdehyde,nitric oxide,hemeoxygenase-1,catalase and superoxide dismutase) were measured.RESULTS:Cerulein administration induced mild pancreatitis,characterized by interstitial edema(total histopathological score of 5.88 ± 0.44vs 0.25 ± 0.16,P < 0.001).Subsequent pancreatic tissue damage resulted in an increase in amylase(2829.71 ± 772.48 vs 984.57 ± 49.22 U/L,P = 0.001) and lipase(110.14 ± 75.84 U/L vs 4.71 ± 0.78 U/L,P < 0.001) in plasma,and leucocytes(6.89 ± 0.48 vs 4.36 ± 0.23,P = 0.001) in peripheral blood.Cytokines,IL-1β(18.81 ± 2.55 pg/μg vs 6.65 ± 0.24 pg/μg,P = 0.002) and IL-6(14.62 ± 1.98 pg/μg vs 9.09 ± 1.36 pg/μg,P = 0.04) in pancreatic tissue also increased.Aspirin pretreatment reduced the increase in the aforementioned parameters to a certain degree and partially improved the histopathological alterations caused by cerulein.No evidence of side effects related to chronic ASA administration(e.g.,inflammation or bleeding) was observed in the gastrointestinal tract in macroscopic and histopathological examination.CONCLUSION:Long term ASA pretreatment could prevent and/or ameliorate certain hematological,serological and histological alterations caused by ceruleininduced AP. | Ibrahim Akyazi Evren Eraslan Ahmet Gülubuk Elif Ergül Ekiz Zeynep L rakli Damla Haktanir Deniz Aktaran Bala Mete zkurt Erdal Matur Mukaddes zcan | 2013 | World Journal of Gastroenterology2013，19，19： | 5 |
| 2 | Conservative restoration of severely damaged endodontically treated pre- molar teeth: a FEM study显示文摘 | Eras Eraslan O Esldtascm:lu G | 2011 | Clin Oral Invest2011，15，3： | 1 |
| 3 | Effect of Restoration Technique on Stress Distribution in Roots with Flared Canals: An FEA Study显示文摘 | Belli S Eraslan O Eskitascioglu G | 2014 | The journal of adhesive dentistry2014，16，2： | 1 |
| 4 | Eimeria stiedae:experimental infection in rabbits and the effect of treatment with toltrazuril and ivermectin显示文摘 | AM Y ATASEVER A ERASLAN G | 2008 | Exp Parasitol2008，119，1： | 1 |
| 5 | Evaluation of protective effect of bee pollen against propoxur toxicity in rat 显示文摘 | ERASLAN G KANBUR M SILICI S | 2009 | Ecotoxicology and Environmental Safety2009，72，： | 1 |
| 6 | The effects of flaxseed oil on cadmium- induced oxidative stress in rats 显示文摘 | Karaca S Eraslan G | 2013 | Biological Trace Element Research2013，155，3： | 1 |
| 7 | The effects of eve-ning primrose oil on lipid peroxidation induced by subacute afla-toxin exposure in mice显示文摘 | Kanbur M Eraslan G Sarca Z S | 2011 | Food Chem Toxicol2011，49，9： | 1 |
| 8 | Conservative restoration of severely damaged endodontically treated premolar teeth: a FEM study显示文摘 | Eraslan O Eraslan O Eskitascioglu G | 2011 | Clin Oral Investig2011，15，3： | 1 |
| 9 | The effects of evening primrose oil on arsenic-induced oxidative stress in rats 显示文摘 | KAYA Z ERASLAN G | 2013 | Toxicological & Environmental Chemistry2013，，： | 1 |
| 10 | Effects of fluoride on lipid peroxidation in rabbits 显示文摘 | Akdogan M Eraslan G Gultekin F | 2004 | Fluoride2004，37，3： | 1 |
| 11 | Effect of earbaryl on some biochemical ehanges in rats: the ameliorative effect of bee pollen 显示文摘 | ERASLAN G KANBUR M SILICI S | 2009 | Food ChemToxicol2009，47，1： | 1 |
| 12 | Effects of some quinolone antibiotics on malondialdehyde levels and catalase activity in chicks 显示文摘 | Ahinordulu S Eraslan G | 2009 | Food Chem Toxicol2009，47，11： | 1 |
| 13 | Incidence of and risk factors for increased intraocular pressure after penetrating keratoplasty显示文摘 | Karadag O Kugu S Erdogan G Kandemir B Eraslan Ozdil S Dogan OK | | 0，，03： | 1 |
| 14 | Prophylactic effect of N-acetylcysteine against sodiumfluoride-induced bloodoxidative stress in mice显示文摘 | Levent Alt tlntas Dinc Essiz Gkhan Eraslan Sinan Ince EmreArslanbas | 2010 | Food and Chemi-cal Toxicology2010，48，： | 1 |
| 15 | Effects of sodium fluoride exposure on some biochemical parameters inmice:Evaluation of the ameliorative effect of royal jelly applications onthese parameters显示文摘 | Murat Kanbur Gkhan Eraslan Sibel Silici Mürsel Karabacak | 2009 | Food and Chemical Toxicology2009，47，： | 1 |
| 16 | Studies on antioxidant enzymes in mice exposed to pulsed elec- tromagnetic fields 显示文摘 | ERASLAN G BILGILI A AKDOGAN M | 2007 | Ecotoxicology and Environmental Safety2007，66，： | 1 |
| 17 | Evaluation of protective effect of bee pollen against propoxur toxicity in rat 显示文摘 | Eraslan G Kanbur M Silici S | 2009 | Ecotoxicology and Environmental Safety2009，72，3： | 1 |
| 18 | Evaluation of aspect of some oxidative stress parameters using vitamin E, proanthocyanidin and N--acetylcysteine against exposure to cyfluthrin in mice显示文摘 | Eraslan G Saygi S Essiz D | 2007 | Pesticide Biochemistry and Physiology2007，88，1： | 1 |
| 19 | Monoblocks in root canals : a finite elemental stress analysis study 显示文摘 | Belli S Eraslan O Eskitascioglu G | 2011 | Int Endod J2011，44，9： | 1 |
| 20 | Monoblocks in root canals: a finite elemental stress analysis study 显示文摘 | Belli S Eraslan O Eskitascioglu G | 2011 | Int Endod J2011，44，9： | 1 |
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