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| 1 | Transrectal ultrasound and magnetic resonance imaging measurement of extramural tumor spread in rectal cancer显示文摘AIM:To evaluate the agreement between transrectal ultrasound(TRUS) and magnetic resonance imaging(MRI) in classification of ≥ T3 rectal tumors.METHODS:From January 2010 to January 2012,86 consecutive patients with ≥ T3 tumors were included in this study.The mean age of the patients was 66.4 years(range:26-91 years).The tumors were all ≥ T3 on TRUS.The sub-classification was defined by the penetration of the rectal wall:a:0 to 1 mm;b:1-5 mm;c:6-15;d:> 15 mm.Early tumors as ab(≤ 5 mm) and advanced tumors as cd(> 5 mm).All patients underwent TRUS using a 6.5 MHz transrectal transducer.The MRI was performed with a 1.5 T Philips unit.The TRUS findings were blinded to the radiologist performing the interpretation of the MRI images and measuring the depth of extramural tumor spread.RESULTS:TRUS found 51 patients to have an early ≥ T3 tumors and 35 to have an advanced tumor,whereas MRI categorized 48 as early ≥ T3 tumors and 38 as advanced tumors.No patients with tumors classified as advanced by TRUS were found to be early on MRI.The kappa value in classifying early versus advanced T3 rectal tumors was 0.93(95% CI:0.85-1.00).We found a kappa value of 0.74(95% CI:0.63-0.86) for the total sub-classification between the two methods.The mean maximal tumor outgrowth measured by TRUS,5.5 mm ± 5.63 mm and on MRI,6.3 mm ± 6.18 mm,P = 0.004.In 19 of the 86 patients the following CT scan or surgery revealed distant metastases;of the 51 patients in the ultrasound ab group three(5.9%) had metastases,whereas 16(45.7%) of 35 in the cd group harbored distant metastases,P = 0.00002.The odds ratio of having distant metastases in the ultrasound cd group compared to the ab group was 13.5(95% CI:3.5-51.6),P = 0.00002.The mean maximal ultrasound measured outgrowth was 4.3 mm(95% CI:3.2-5.5 mm) in patients without distant metastases,while the mean maximal outgrowth was 9.5 mm(95% CI:6.2-12.8 mm) in the patients with metastases,P = 0.00004.Using the MRI classification three(6.3%) of 48 in the MRI ab group had distant metastases,while 16(42.1%) of the 38 in the MRI cd group,P = 0.00004.The MRI odds ratio was 10.9(95% CI:2.9-41.4),P = 0.00008.The mean maximal MRI measured outgrowth was 4.9 mm(95% CI:3.7-6.1 mm) in patients without distant metastases,while the mean maximal outgrowth was 11.5 mm(95% CI:7.8-15.2 mm) in the patients with metastases,P = 0.000006.CONCLUSION:There is good agreement between TRUS and MRI in the pretreatment sub-classification of ≥ T3 tumors.Distant metastases are more frequent in the advanced group. | Sφren R Rafaelsen Chris Vagn-Hansen Torben Sφrensen John Plφen Anders Jakobsen | 2012 | World Journal of Gastroenterology2012，18，36： | 14 |
| 2 | Major-effect candidate genes identified in cultivated strawberry(Fragaria×ananassa Duch.)for ellagic acid deoxyhexoside and pelargonidin-3-O-malonylglucoside biosynthesis,key polyphenolic compounds显示文摘Strawberries are rich in polyphenols which impart health benefits when metabolized by the gut microbiome,including anti-inflammatory,neuroprotective,and antiproliferative effects.In addition,polyphenolic anthocyanins contribute to the attractive color of strawberry fruits.However,the genetic basis of polyphenol biosynthesis has not been extensively studied in strawberry.In this investigation,ripe fruits from three cultivated strawberry populations were characterized for polyphenol content using HPLC-DAD-MSn and genotyped using the iStraw35k array.GWAS and QTL analyses identified genetic loci controlling polyphenol biosynthesis.QTL were identified on four chromosomes for pelargonidin-3-O-malonylglucoside,pelargonidin-3-O-acetylglucoside,cinnamoyl glucose,and ellagic acid deoxyhexoside biosynthesis.Presence/absence of ellagic acid deoxyhexoside and pelargonidin-3-O-malonylglucoside was found to be under the control of major gene loci on LG1X2 and LG6b,respectively,on the F.×ananassa linkage maps.Interrogation of gene predictions in the F.vesca reference genome sequence identified a single candidate gene for ellagic acid deoxyhexoside biosynthesis,while seven malonyltransferase genes were identified as candidates for pelargonidin-3-O-malonylglucoside biosynthesis.Homologous malonyltransferase genes were identified in the F.×ananassa‘Camarosa’genome sequence but the candidate for ellagic acid deoxyhexoside biosynthesis was absent from the‘Camarosa’sequence.This study demonstrated that polyphenol biosynthesis in strawberry is,in some cases,under simple genetic control,supporting previous observations of the presence or absence of these compounds in strawberry fruits.It has also shed light on the mechanisms controlling polyphenol biosynthesis and enhanced the knowledge of these biosynthesis pathways in strawberry.The above findings will facilitate breeding for strawberries enriched in compounds with beneficial health effects. | Jahn Davik Kjersti Aaby Matteo Buti Muath Alsheikh NadaŠurbanovski Stefan Martens Dag Røen Daniel James Sargent | 2020 | Horticulture Research2020，7，1： | 2 |
| 3 | Effect of activity and television viewing on BMI z-score in early adolescents in Turkey显示文摘 | Ozmert EN Ozdemir R Pektas A | 2011 | World J Pediatr2011，7，1： | 1 |
| 4 | A novel drought-inducible gene,A TAF1,encodes a NAC family protein that negatively regulates the expression of stress-responsive genes in Arabidopsis显示文摘 | LU P L CH EN N Z AN R SU Z QI B S REN F CHEN J WANG X C | 2007 | Plant Molecular Biology2007，63，2： | 1 |
| 5 | Nerve sparing endoscopic extraperitoneal radical prostatectomy: effect of pubo?prostatic ligament preservation on early continence and positive margins显示文摘 | Stolzenburg JU Liatsikos EN Rabenalt R | 2006 | Eur Urol2006，49，1： | 1 |
| 6 | Intelligent agents, theory and practice 显示文摘 | WOOLDBRIGE M J J ENNINGS N R | 1995 | Knowledge Engineering Review1995，10，2： | 1 |
| 7 | Qualitative and quantitative determination of the major coumarins in Zushima by high performance liquid chrom atography with diode array detector and mass spectrometry 显示文摘 | SU J ZHANG C ZHANG W SH EN Y H LIH H LIU R H ZHANG X HU X J ZHANG W D | 2009 | J Chromatogr: A2009，1216，11： | 1 |
| 8 | Phosphorylation of apolipoprotein-E at an atypical protein kinase CK2 PSD/E site in vitro 显示文摘 | Raftery M Campbell R Glaros EN | 2005 | Biochemistry2005，44，19： | 1 |
| 9 | 显示文摘 | Toscano J Vaβen R Gil A | 2006 | Surface and Coatings Technology2006，201，7： | 1 |
| 10 | Incidence and clini-cal characteristics of the infection by the respiratory syncytialvirus in children admitted in Santa Casa de Sao Paulo Hospital显示文摘 | Pecchini R Berezin EN Felicio MC eiaZ | 2008 | Braz J Infect Dis2008，12，： | 1 |
| 11 | Regulation of angiogenesis and choroidal neovasculariza- tion by members of microRNA-23 - 27 - 24 clusters 显示文摘 | Zhou Q Gallagher R Ufret-Vincenty R Li X Olson EN Wang S | 2011 | Proc Natl Acad Sci USA2011，108，20： | 1 |
| 12 | CCL5 promotes proliferation of MCF-7 cells through mTOR-dependent mRNA translation 显示文摘 | Murooka Tr Rahbar R Fish EN | 2009 | Biochem Biophysic Res Commu2009，387，2： | 1 |
| 13 | Study of bond strengths of a water -bome polyurethane (PU) adhesive for shoe - soling materials 显示文摘 | ROY D CH EN R CALLAGHAN P | 2005 | Journal of the Textile Institute2005，9，1： | 1 |
| 14 | Use of a fluorimetric test for bovine alkaline phospatase to demonstrate under-pasteurisation of skimmed milk and cream显示文摘 | ANTIA M R MELODY H G GARETH EN D | 2004 | International Dairy Journal2004，14，： | 1 |
| 15 | Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes显示文摘 | Sampaio EP Sarno EN Galilly R | 1991 | J Exp Med1991，173，3： | 1 |
| 16 | Association analysis of CFH,C2,BF,and HTRA1 gene polymorphisms in Chinese patients With polypoidal choroidal vasculopathy显示文摘 | Lee KY Vithana EN Mathur R | 2008 | Invest Ophthatmol Vis Sc2008，49，： | 1 |
| 17 | Long-tem follow- up of 34 adults with isolated left ventricular noncompaction : a dis-tinct cardiomyopathy with poor prognosis 显示文摘 | Oechslin EN Attenhofer Just CH Rojas J R | 2000 | J Am Coll Cardiol2000，36，2： | 1 |
| 18 | A Kinematic Notationfor Lower-pair Mechanisms Based on Matrices 显示文摘 | D EN AVITJ HARTENBERG R S | 1955 | ASMJournal of Applied Mechanics1955，22，2： | 1 |
| 19 | Thalidomide selec- tively inhibits tumor necrosis factor alpha production by stimulated human monocytes显示文摘 | Sampaio EP Sarno EN Galilly R | 1991 | J Exp Med1991，193，3： | 1 |
| 20 | Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair显示文摘 | Xin M Olson EN Bassel-Duby R | 2013 | Nat Rev Mol Cell Biol2013，14，8： | 1 |
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