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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 3 | Subgenomic RNA7 is transcribed with different leader-body junction sites in PRRSV (strain VR2332) infection of CL2621 cells显示文摘 | Faaberg K S Elam M R Nelsen C J | 1998 | Adv Exp Med Biol1998，440，： | 1 |
| 4 | Morphological changes in adult males from resistance exercise and amino acid supplementa- tion 显示文摘 | ELAM R P | 1988 | Journal of Sports Medicine and Physical Fit- ness1988，28，1： | 1 |
| 5 | Comparison of the structural protein coding sequences of the VR-2332 and Lelystad virus strains of the PRRS virus显示文摘 | Murtaugh M P Elam M R Kakach L | 1995 | Archives of Virology1995，140，： | 1 |
| 6 | Population genetic consequences of population size:implications for plant conservation显示文摘 | Ellstrand N C Elam D R | 1993 | Annual Review of Ecology and Systematic1993，24，： | 1 |
| 7 | Comparison of the structural protein coding sequences of the VR2332 and Lelystad virus strains of the PRRS virus 显示文摘 | Murtaugh M P Elam M R Kakach L T | 1995 | Arch Virol1995，140，： | 1 |
| 8 | Comparison of the structural protein coding sequences of the VR-2332 and Lelys- tad virus strains of the PRRS virus显示文摘 | Murtaugh M P Elam M R Kakach L T | 1995 | Arch Virol1995，140，： | 1 |
| 9 | Genetic variation in porcine reproductive and respiratory sydrome virus isolates in the Midwestern United States 显示文摘 | Kapur V Elam M R Pawlovich T M | 1996 | J Gen Virol1996，77，： | 1 |
| 10 | Comparison of the structural protein coding sequences of the VR22332 and Lelystad virus strains of the PRRS virus 显示文摘 | Murtaugh M P Elam M R Kakach LT | 1995 | Arch Virol1995，140，： | 1 |
| 11 | Continuous auditing: the audit of the future显示文摘 | Rezaee Z Elam R Sharbatoghlie A | 2001 | Managerial Auditing Journal2001，16，3： | 1 |
| 12 | Genetic variation in porcine reproductive and respiratory syndrome virus isolates in the midwestern United States 显示文摘 | Kapur V Elam M R Pawlovich T M | 1996 | J Gen Virol1996，77，： | 1 |
| 13 | Comparison of the structural protein coding se- quences of the VR-2332 and Lelystad virus strains of the PRRS virus 显示文摘 | MURTAUGH M P ELAM M R KAKACH L T | 1995 | Arch Virol1995，140，： | 1 |
| 14 | Comparison of the structural protein coding sequences of the VR-2332 and Lelystad Virus strains of the PRRS virus 显示文摘 | Murtaugh M P Elam M R Kakach L T | 1995 | Arch Virol1995，140，： | 1 |
| 15 | Population genetic consequences of small population size :implications for plant conservation 显示文摘 | Ellstrand N C Elam D R | 1993 | Annual review of Ecology and Systematics1993，24，： | 1 |
| 16 | Continuous au- diting: building automated auditing capability 显示文摘 | REZAEE Z SHARBATOGHILE A ELAM R | 2002 | Auditing: A Journal of Practice and Theory2002，21，1： | 1 |
| 17 | Genetic variation in porcine reproductive and respiratory syndrome virus, isolates in the midwestern United States 显示文摘 | Kapur V Elam M R Pawlovich T M | 1996 | J Gen Virol1996，77，： | 1 |
| 18 | Population Genetic Consequences of Small Population Size:Implications for Plant Conservation显示文摘 | Ellstrand N C Elam D R | 1993 | Annual Review of Ecology and Systematics1993，24，： | 1 |
| 19 | Population genetic consequences of small population size: implications for plant conservation显示文摘 | ELLSTRAND N C ELAM D R | 1993 | Annual Review of Ecological Systems1993，24，： | 1 |
| 20 | Amyloid-like filaments and water-fined nanotobes formed by SODI mutant proteins linked to familial ALS显示文摘 | Elam J S Taylor A B Strange R | 2003 | Nat Struet Biol2003，10，6： | 1 |
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