|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 抗生素耐药性环境中产生和转移的人类健康风险评估(HHRA)显示文摘[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性病原体所致的抗生素治疗失败中所起的作用。[方法]作者参加了2012年3月4—8日在加拿大魁北克省举行的研讨会,定义抗生素耐药性风险与人类健康环境评估的范围和目标。我们专注于环境中耐药性产生'热点区域'的关键要素,(与食品无关的)暴露评估以及剂量反应,以描述风险特征,从而改善抗生素耐药性管理的方案。[讨论]识别传统风险评估中有助于评估环境中抗生素耐药性的各个新方面。包括:a)解释附加的选择压力对环境耐药基因组的作用,即随着时间的推移,促使抗生素耐药性细菌(ARB)产生;b)在相关的环境组成部分的'热点区域'中识别和描述水平基因转移(HGT)率;c)针对不同健康结局和途径的ARB剂量修改传统的剂量反应方法。[结论]我们建议将抗生素耐药性产生造成的环境影响纳入所有涉及ARB的HHRA过程之中。由于可用的数据有限,一种多标准决策分析方法将有助于进行环境中抗生素耐药性的HHRA,并使风险管理者了解环境抗生素耐药性。 | Nicholas J.Ashbolt Alejandro Amézquita Thomas Backhaus Peter Borriello Kristian K.Brandt Peter Collignon Anja Coors Rita Finley William H.Gaze Thomas Heberer John R.Lawrence D.G.Joakim Larsson Scott A.McEwen James J.Ryan Jens Schnfeld Peter Silley Jason R.Snape Christel Van den Eede Edward Topp 王晓宇 张伊人 操仪 | 2014 | 环境与职业医学2014，31，2： | 3 |
| 2 | Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenie mice expressing transmembrane tumor necrosis factor alpha显示文摘 | Edwards CK Bendele AM Reznikov LI | 2006 | Arthritis Rheum2006，54，9： | 1 |
| 3 | BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis 显示文摘 | Edwards PA Kast HR Anisfeld AM | 2002 | J Lipid Res2002，43，： | 1 |
| 4 | Diabetic neuropathy: mechanisms to management 显示文摘 | Edwards JL Vincent AM Cheng HT | 2008 | Pharmacol Ther2008，120，1： | 1 |
| 5 | Improved methods for the solubilization and assay of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase 显示文摘 | Edwards PA Lemongello D Fogelman AM | 1979 | J Lipid Res1979，20，1： | 1 |
| 6 | The management of traumatic spondylolisthesis of the axis显示文摘 | Levine AM Edwards CC | 1985 | Bone Joint Surg (Am)1985，67，2： | 1 |
| 7 | Differential expression of c-myc protooncogenes by estrogens,xenobiotics and other growth-stimulatory agents in primary rat hepatocytes显示文摘 | Lee CH Edwards AM | 2003 | Arch Toxicol2003，77，3： | 1 |
| 8 | Myocardial ischaemia during tracheal intubation and extubation显示文摘 | Edwards ND Alford AM Dobson PM | 1994 | Br J Anaesth1994，73，： | 1 |
| 9 | Fractures of the arlas显示文摘 | Levine AM Edwards CO | 1991 | J Bone Joint Surg Am1991，73，5： | 1 |
| 10 | Comparison of quadriceps and hamstringtoque values during isokinetic exercise 显示文摘 | Wyatt MP Edwards AM | 1981 | J Orthop Sports Phys Ther1981，3，2： | 1 |
| 11 | The managementof traumatic spondylolisthesis of the axis 显示文摘 | Levine AM Edwards CC | 1985 | J Bone Joint Surg (Am)1985，67，： | 1 |
| 12 | Stimulation via Toll-like receptor 9 reduces Cryptococcus neoformansindueed pulmonary inflammation in an IL-12-dependent manner显示文摘 | EDWARDS L WILLIAMS AE KRIEG AM | 2005 | Ear J Immuaol2005，35，1： | 1 |
| 13 | Targeted treatment of recurrent platinum-resistant ovarian cancer:current and emerging therapies显示文摘 | Mantia-Smaldone GM Edwards RP Vlad AM | 2011 | Cancer Manag Res2011，3，： | 1 |
| 14 | The management of traumatic spondylolisthesis of the axis 显示文摘 | Levine AM Edwards CC | 1985 | J Bone Joint Surg Am1985，67，2： | 1 |
| 15 | Fracture of the atlas显示文摘 | Levine AM Edwards CC | 1991 | J Bone Joint Surg Am1991，73，68： | 1 |
| 16 | The management of traumatic spondylolisthesis of the axis显示文摘 | Levine AM Edwards CC | 1985 | J Bone Joint Surg Am1985，67，2： | 1 |
| 17 | BAREing it all:the adoption of LXR and FXR and their roles in lipid homeostasis显示文摘 | Edwards PA Kast HR Anisfeld AM | 2002 | J Lipid Res2002，43，1： | 1 |
| 18 | The management of traumatic spondylolisthesis of the axis显示文摘 | l evine AM Edwards CC | 1985 | J Bone Joint Surg Am1985，67，： | 1 |
| 19 | The management of traumatic spon- dylolisthesis of the axis显示文摘 | Levine AM Edwards CC | 1985 | J Bone Joint Surg Am1985，67，2： | 1 |
| 20 | Annual report to the nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal,breast, or prostate cancer显示文摘 | Edwards BK Noone AM Mariotto AB | 2014 | Cancer2014，120，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员