|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool显示文摘Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and function.However,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory conditions.Here,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R signaling.Under noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune disease.In contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments.Moreover,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets.Thus,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool. | Marc Permanyer Berislav Bošnjak Silke Glage Michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 2 | High strength magnesium-based glass matrix composites显示文摘 | BARTUSCH B SCHURACK F ECKERT J | 2002 | Mater Trans JIM2002，43，： | 1 |
| 3 | Comparison of viability assays for Cryptosporidium parvum oocysts' after disinfection 显示文摘 | Joachim A Eckert E Petry F | 2003 | Veterinary Parasitology2003，111，1： | 1 |
| 4 | Control of diseases of fruits and vegetables by post harvested treatment显示文摘 | Eckert J W Sommer N F | 1967 | Ann Rev Phytopathol1967，，5： | 1 |
| 5 | Preclinical studies with prothymosin alpha on mononuclear cells from tumor patients 显示文摘 | Eckert K Grunberg E Garbin F | 1997 | Int J Immunopharmacol1997，19，910： | 1 |
| 6 | Chemotherapy of Alveolar Echinococcsis:Comparison of Plasma Mebendazole Concentrations in Animals and Man显示文摘 | Witassek F Burkhardt B Eckert J | 1981 | Eur J Clin Pharmacol1981，20，： | 1 |
| 7 | Epigal-locatechin-3-gallate inhibits epidermal growth factorreceptor signaling pathway-evidence for direct inhibi-tion of ERK1/2 and AKT kinases显示文摘 | Sah J F Balasubramanian S Eckert R L | 2004 | J Biol Chem2004，279，12： | 1 |
| 8 | Fracture mechanisms in bulkmetallic glassy materials显示文摘 | Zhang Z F He G Eckert J | 2003 | Physical Review Letters2003，91，4： | 1 |
| 9 | Adding selectivity to antimicrobial peptides:rational design of a multidomain peptide against Pseudomonas spp显示文摘 | Eckert R Qi F Yarbrough D K | | 0，，04： | 1 |
| 10 | Interracial area of dis persions of sulfuric acid and hydrocarbons显示文摘 | Ende D J Eckert R E Albright L F | 1995 | Industrial Engineering Chemistry Research1995，34，12： | 1 |
| 11 | Difference in compressive and tensile fracture mechanisms of Zr59Cu20A110Ni8Ti3 bulk metallic glass 显示文摘 | Zhang Z F Eckert J Schuhz L | 2003 | Acta Materialia2003，51，4： | 1 |
| 12 | Difference in compressive and tensile fracture mechanisms of Zr59Cu20Al10 Ni8Ti3 bulk metallic glass 显示文摘 | Zhang Z F Eckert J Schultz L | 2003 | Acta Mater2003，51，4： | 1 |
| 13 | Zeolite-like metal-organic frameworks(ZMOFs) as hydrogen storage platformz Lithium and magnesium ion-excfiange and H2-(rho-ZMOF) interaction studies显示文摘 | Nouar F Eckert J Eubank J F | 2009 | J Am Chem Soc2009，131，8： | 1 |
| 14 | Formation and separation of sulfuricacid / n-Heptane dispersions: Applications to alkylation显示文摘 | Albright L F Roger E Eckert | 2001 | Indus-trial and Engineering Chemistry Research2001，40，： | 1 |
| 15 | High strength magnesium-based glass matrix composites 显示文摘 | Bartusch B Schurack F Eckert J | 2002 | Materials Transactions JIM2002，43，8： | 1 |
| 16 | High strength Magnesium-based glass matrix composites 显示文摘 | Bartusch B Schurack F Eckert J | 2002 | Mater Trans JIM2002，43，8： | 1 |
| 17 | High strength magnesium-based glass matrix composites显示文摘 | Bartusch B Schurack F Eckert J | 2002 | Mater Trans JIM2002，43，15： | 1 |
| 18 | Diagnosis of Clostridium difficile infection : the molecular approach 显示文摘 | Eckert C Jones G Barbut F | 2013 | Future Microbiol2013，8，： | 1 |
| 19 | Epidemiology and control of Clostridium diffieile infections in healthcare settings:an update显示文摘 | Barbut F Jones G Eckert C | 2011 | Curr Opin Infect Dis2011，24，4： | 1 |
| 20 | Temperature-, pH-, and magnetic-field-sensitive hybrid microgels 显示文摘 | Bhattacharya S Eckert F Boyko V | 2007 | Small2007，3，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员