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| 1 | 血栓形成的抗栓治疗和预防,第9版:美国胸科医师学院循证的临床实践指南显示文摘【缩写】ACS=急性冠脉综合征;AF=心房纤颤;AIS=动脉性缺血性卒中;APLA=抗磷脂抗体;ASA=阿司匹林;AT9=第9版血栓的抗栓治疗和预防:美国胸科医师学院循证的临床实践指南;BMS=裸金属支架;CABG=冠状动脉旁路移植术;CAD=冠状动脉疾病;CDT=导管接触溶栓;CHADS2=充血性心力衰竭,高血压,年龄≥75岁,糖尿病,有卒中或TIA病史; | 潘元美 曹雯炜 秦洁行 周洁茹 金海峰 朱莹 李焰生 Guyatt GH Akl EA Crowther M Gutterman DD Schu nemann HJ | 2012 | 神经病学与神经康复学杂志2012，9，1： | 195 |
| 2 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 3 | MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells显示文摘 | Godlewski J Nowicki MO Bronisz A Nuovo G Palatini J De Lay M Van Brocklyn J Ostrowskl MC Chlocca EA Lawler SE. | 2010 | 中国神经肿瘤杂志2010，8，1： | 37 |
| 4 | 淡化糖尿病的分型显示文摘现有的糖尿病分型有很大的局限性和逻辑上的矛盾,在临床工作中很不实用。分型对认识疾病和临床治疗有一定的帮助,但同时也限制了我们的思维空间。作者的意见并非要取消现有的分类方法,而是呼吁摒弃类别思维,淡化分型观念,把更多的精力放在糖尿病发病机理的研究上,更好的解决临床实际问题。2型糖尿病也包括免疫机制,而1型糖尿病也有非免疫机制——这并不是说这两种状况必须完全相同。 | Gale EA 陈洁莉 邱明才 | 2006 | 国际内分泌代谢杂志2006，26，6： | 19 |
| 5 | Antidiabetic and haematological effect of aqueous extract of stem bark of Afzelia africana(Smith) on streptozotocin-induced diabetic Wistar rats显示文摘Objective:To investigate the antidiabetic properties of aqueous extract of stem bark of Afzelia africana(A.africana)and its beneficial effect on haematological parameters in streptozotocin induced diabetic rats.Methods:A total of 30 rats including 24 diabetic and 6 normal rats were used for this study.Diabetes was induced in male Wistar rats by intraperitoneal injection of streptozotocin.After being confirmed diabetic,animals were orally treated with distilled water or extracts at 100 or 200 mg/kg body weight daily for 10 days.The haematological parameters including red blood and white blood cells and their functional indices were evaluated in diabetic treated groups compared with the controls.Results:The extract significantly reduced the blood glucose levels while the best result was obtained at 200 mg/kg body weight The feed and water intake in diabetic rats were significantly reduced while weight loss was minimized at both dosages.Similarly,the levels of red blood,white blood cells and their functional indices were significantly improved after extract administration at both doses.Conclusions:It can be concluded that the aqueous extract of bark of A.africana possesses antihyperglycemic properties.In addition,the extract can prevent various complications of diabetes and improve some haematological parameters.Further experimental investigation is needed to exploit its relevant therapeutic effect to substantiate its ethnomedicinal usage. | Oyedemi SO Adewusi EA Aiyegoro OA Akinpelu DA | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，5： | 11 |
| 6 | Dynamic Contrast-Enhanced Perfusion MR Imaging Measurements of Endothelial Permeability: Differentiation between Atypical and Typical Meningiomas显示文摘BACKGROUND: AND PURPOSE: The measurement of relative cerebral blood volume (rCBV) and the volume transfer constant (K(trans)) by means of dynamic contrast-enhanced (DCE) perfusion MR imaging (pMRI) can be useful in characterizing brain tumors. The purpose of our study was to evaluate the utility of these measurements in differentiating typical meningiomas and atypical meningiomas. METHODS: Fifteen patients with pathologically confirmed typical meningiomas and seven with atypical meningiomas underwent conventional imaging and DCE pMRI before resection.rCBV measurements were calculated by using standard intravascular | Law M Zagzag D Golfinos JG Knopp EA Johnson G | 2003 | 中国神经肿瘤杂志2003，1，3： | 10 |
| 7 | 静脉血栓栓塞症的抗血栓治疗:美国《胸科学》杂志指南显示文摘包括深静脉血栓和肺栓塞在内的静脉血栓栓塞症是癌症患者的主要并发症,发生率为4%~20%,并且是常见的潜在致命性急症。本文介绍了美国《胸科学》杂志指南中VET的抗血栓治疗的部分内容,其以第9版《美国胸内科医师学会循证临床实践指南》中的《静脉血栓栓塞症的抗血栓治疗:抗血栓治疗和阻止血栓形成》一文为参照,基于静脉血栓栓塞症治疗的Ⅲ期试验的发表年份,对口服抗凝剂(达比加群、利伐沙班、阿哌沙班、依度沙班)进行先后阐述(但是这一排序并不是指南专家组对药剂的优劣排序),以为临床医生提供参考。 | Kearon C Akl EA Ornelas J Blaivas A Jimenez D Bounameaux H Huisman M King CS MorrisT Sood N Stevens SM Vintch JRE Wells P Woller SC Moores CL 本刊编辑部 | 2016 | 中国全科医学2016，19，9： | 10 |
| 8 | 小胶质细胞对星形胶质细胞的免疫和神经保护功能的调节作用(英文)显示文摘在中枢神经系统中,小胶质细胞和星形胶质细胞对神经元的发育、功能维持及细胞存活具有重要的作用。但在炎症反应过程中,星形胶质细胞增生的作用及其对神经元的影响目前并不十分清楚。因此,本研究对不同种类的细胞进行培养,给予细菌脂多糖(lipopolysaccharide,LPS)刺激,观察各种细胞的反应。结果显示,星形胶质细胞可以减轻炎症反应的神经元毒性,提示星形胶质细胞增生主要具有神经保护作用。如果去掉上清液中由星形胶质细胞分泌的胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF),这种神经保护作用显著降低。为了研究星形胶质细胞的免疫功能,本研究培养了高浓度的星形胶质细胞,并发现LPS不能诱导肿瘤坏死因子(tumor necrosis factor,TNF)-α及诱导型一氧化氮合酶(inducible nitric oxide synthase,iN OS)/一氧化氮(nitric oxide,NO)(iN OS/NO)释放。但如果在培养的高浓度星形胶质细胞中增加0.5%~1%的小胶质细胞,则可以诱导TNF-α及iN OS/NO的释放。这提示小胶质细胞和星形胶质细胞间的相互作用对于LPS诱导星形胶质细胞释放前炎症因子及GDNF是必须的。我们还发现,小胶质细胞释放的TNF-α可以通过旁分泌作用调节星形胶质细胞的神经保护功能。综上所述,本研究结果提示星形胶质细胞可能不会直接被LPS激活,而是通过与小胶质细胞相互作用被激活,释放神经营养因子,减少因炎症反应激活的小胶质细胞释放的毒性物质对神经元的损害作用。 | Chen SH Oyarzabal EA Sung YF Chu CH Wang Q Chen SL Lu RB Hong JS 唐颖馨 | 2015 | 神经损伤与功能重建2015，10，1： | 9 |
| 9 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 10 | 低社会经济地位与美国成年人早发冠状动脉粥样硬化性心脏病的关系显示文摘低社会经济地位(socioeconomic status,SES)的个体承担着不成比例的冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)负担。在美国低收入地区,CHD仍然是死亡的主要原因。该研究旨在评估美国低SES个体的过量CHD负担,以及传统风险因素和与低SES相关因素影响所占的比例。 | Hamad R Penko J Kazi DS Coxson P Guzman D Pengxiao C.Wei Mason A Wang EA Goldman L Fiscella K Bibbins-Domingo K 周卫(译) 刘莉(审校) | 2020 | 中华高血压杂志2020，28，7： | 7 |
| 11 | In vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from southern Africa显示文摘Objective:To determine the acetylcholinesterase inhibitory(AChE1) and antioxidant activity of the ethyl acetate and methanol extracts of 12 traditional medicinal plants used in the treatment of neurological disorders.Methods:AChEI activity was determined spectrophotometrically using the Ellman’s colorimetric method.Antioxidant activity was carried out by determining the ability of the extracts to scavenge 2,2-diphenyl-1-picryl hydrazyl(DPPH) and 2,2’-azinobis- 3-ethylbenzothiazoline-6-sulfonic acid(ABTS) radicals.The levels of total phenols,flavonoids and flavonols were determined quantitatively using spectrophotometric methods.Results:AChEI was observed to be dose-dependent.Lannea schweinfurthii(L.schweinfurthii)(Engl.) Engl.and Scadoxus puniceus(S.puniceus)(L.) Friis & I.Nordal.root extracts showed the lowest IC50 value of 0.000 3 mg/mL for the ethyl acetate extracts while Zanthoxylum davyi(Z.davyi)(I.Verd.) P.G. Watermann had the lowest IC50 value of 0.01 mg/mL for the methanol extracts in the AChEI assay. The roots of Piper capense(P.capense) L.f.,L.schweinfurthii,Ziziphus mucronata(Z.mucronata) Willd.,Z.davyi and Crinum bulbispermum(C.bulbispermum)(Burm.f.) Milne-Redh.& Schweick.showed noteworthy radical scavenging activity and good AChEI activity.Conclusions: Five plants show good antioxidant and AChEI activity.These findings support the traditional use of the plants for treating neurological disorders especially where a cholinesterase mechanism and reactive oxygen species(ROS) are involved. | EA Adewusi V Steenkamp | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 7 |
| 12 | 慢性肾脏病老年患者的非透析治疗显示文摘或许今天肾脏病学者面临的最困难的临床决策是他们的老年晚期CKD患者(年龄〉70岁)是否有可能从透析治疗中受益。澳大利亚的所有透析患者中,超过65岁的患者占50%,75岁以上的患者占26%。同样,在美国年龄超过75岁的透析群增长最快,在英国增长最快的透析群则是超过65岁。不幸的是,老年透析患者的生存期通常比大多数癌症患者都要差。 | Brown MA Collett GK Josland EA 王建中 | 2015 | 中华肾病研究电子杂志2015，4，2： | 7 |
| 13 | 急性儿茶酚胺暴露引起可逆的无心脏细胞再生的心肌细胞损伤显示文摘儿茶酚胺增加心脏收缩力,但暴露于高浓度儿茶酚胺或长时间暴露可引起心脏损伤。最近的一项研究表明,小鼠单次皮下注射异丙肾上腺素(isoproterenol,ISO;200 mg/kg)导致急性心肌细胞死亡(8%-10%),但在1个月之内心脏完整修复。心脏再生是通过内源性原癌基因蛋白质cKit+心脏干细胞介导新的心肌细胞形成。 | 刘莉 叶鹏 Wallner M Duran JM Mohsin S Troupes CD Vanhoutte D Borghetti G Vagnozzi RJ Gross P Yu D Trappanese DM Kubo H Toib A Sharp TE Harper SC Volkert MA Starosta T Feldsott EA Berretta RM Wang T Barbe MF Molkentin JD Houser SR | 2016 | 中华高血压杂志2016，24，8： | 4 |
| 14 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 15 | Serial intravenous doses of dezocine, morphine, and nalbuphine in the management of postoperative pain for outpatients 显示文摘 | Cohen RI Edwards WT Kezer EA | 1993 | Anesth Analg1993，77，3： | 3 |
| 16 | Current perspectives on camptothecins in cancer teatment 显示文摘 | Dancey J Eisenhauer EA | 1996 | Br J Cancer1996，74，3： | 3 |
| 17 | Immnohistochemical detection of p53 protein in mammry carcinoma:an important new independent indicator of prognosis显示文摘 | Barnes DM Dublin EA Fisher CJ | 1993 | Hum Pathol1993，24，： | 2 |
| 18 | 患者独处诊室血压和非独处诊室血压与临床前靶器官损害的关系显示文摘患者独处的自动诊室血压或自动血压测量方法可能优于传统血压测量方法。目前一些国际指南建议自动化测量血压作为血压测量的首选方法。与标准血压测量方法所获数据比较,自动化测量血压与心血管事件的关系并不明确。初步数据显示:自动化测量血压可能与靶器官损害更相关。该研究的目的是评估在欧洲高血压学会卓越中心(excellence center)行超声心动图及颈动脉超声检查的564例患者独处诊室血压、非独处诊室血压与靶器官损害的关系。 | Salvetti M Paini A Aggiusti C Bertacchini F Stassaldi D Capellini S Ciuceis CD Rizzoni D Gatta R Rosei EA Muiesan ML 赵狄(摘译) 练桂丽(审校) | 2019 | 中华高血压杂志2019，0，3： | 2 |
| 19 | Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart显示文摘 | Mack CA Patel SR Schwarz EA | | 0，，： | 2 |
| 20 | Secrete types of supporting cell in the inner ear express aquaporin-4 water channel protein显示文摘 | Takumi Y Nagelhus EA Eidet J | 1998 | Eur J Neurosci1998，10，： | 2 |
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