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| 1 | Adiponectin,the past two decades显示文摘Adiponectin is an adipocyte-specific factor,first described in 1995.Over the past two decades,numerous studies have elucidated the physiological functions of adiponectin in obesity,diabetes,inflammation,atherosclerosis,and cardiovascular disease.Adiponectin,elicited through cognate receptors,suppresses glucose production in the liver and enhances fatty acid oxidation in skeletal muscle,which together contribute to a beneficial metabolic action in whole body energy homeostasis.Beyond its role in metabolism,adiponectin also protects cells from apoptosis and reduces inflammation in various cell types via receptor-dependent mechanisms.Adiponectin,as a fat-derived hormone,therefore fulfills a critical role as an important messenger to communicate between adipose tissue and other organs.A better understanding of adiponectin actions,including the pros and cons,will advance our insights into basic mechanisms of metabolism and inflammation,and potentially pave theway toward novel means of pharmacological intervention to address pathophysiological changes associated with diabetes,atherosclerosis,and cardiometabolic disease. | Zhao V.Wang Philipp E.Scherer | 2016 | Journal of Molecular Cell Biology2016，8，2： | 12 |
| 2 | 脂肪组织:从脂肪储存库到内分泌器官——2005年第65届ADA年会杰出科学成就奖报告显示文摘 | Philipp E.Scherer 周丽斌 | 2005 | 国外医学(内分泌学分册)2005，25，5： | 4 |
| 3 | Adiponectin – journey from an adipocyte secretory protein to biomarker of the metabolic syndrome显示文摘 | M. E.TRUJILLO P. E.SCHERER | 2005 | Journal of Internal Medicine2005，，2： | 1 |
| 4 | Mechanisms of Trypanosoma cruzi persistence in Chagas disease显示文摘 | FnuNagajyothi Fabiana S.Machado Barbara A.Burleigh Linda A.Jelicks Philipp E.Scherer ShankarMukherjee Michael P.Lisanti Louis M.Weiss Nisha J.Garg Herbert B.Tanowitz | 2012 | Cellular Microbiology2012，，5： | 1 |
| 5 | Adipokines as novel biomarkers and regulators of the metabolic syndrome显示文摘 | YingfengDeng Philipp E.Scherer | 2010 | Annals of the New York Academy of Sciences2010，，1： | 1 |
| 6 | Thermal evolution of an ancient subduction interface revealed by Lue Hf garnet geochronology, Halilba■? Complex(Anatolia)显示文摘The thermal structure of subduction zones exerts a major influence on deep-seated mechanical and chemical processes controlling arc magmatism, seismicity, and global element cycles. Accretionary complexes exposed inland may comprise tectonic blocks with contrasting pressureetemperature(Pe T)histories, making it possible to investigate the dynamics and thermal evolution of former subduction interfaces. With this aim, we present new Lue Hf geochronological results for mafic rocks of the Halilbag?Complex(Anatolia) that evolved along different thermal gradients. Samples include a lawsoniteeepidote blueschist, a lawsoniteeepidote eclogite, and an epidote eclogite(all with counter-clockwise Pe T paths),a prograde lawsonite blueschist with a 'hairpin'-type Pe T path, and a garnet amphibolite from the overlying sub-ophiolitic metamorphic sole. Equilibrium phase diagrams suggest that the garnet amphibolite formed at w0.6 -0.7 GPa and 800 -850℃, whereas the prograde lawsonite blueschist records burial from 2.1 GPa and 420℃ to 2.6 GPa and 520℃. Well-defined Lue Hf isochrons were obtained for the epidote eclogite(92.38 ± 0.22 Ma) and the lawsoniteeepidote blueschist(90.19 ± 0.54 Ma),suggesting rapid garnet growth. The lawsoniteeepidote eclogite(87.30 ± 0.39 Ma) and the prograde lawsonite blueschist(ca. 86 Ma) are younger, whereas the garnet amphibolite(104.5 ± 3.5 Ma) is older.Our data reveal a consistent trend of progressively decreasing geothermal gradient from granulite-facies conditions at ~104 Ma to the epidote-eclogite facies around 92 Ma, and the lawsonite blueschist-facies between 90 Ma and 86 Ma. Three Lue Hf garnet dates(between 92 Ma and 87 Ma) weighted toward the growth of post-peak rims(as indicated by Lu distribution in garnet) suggest that the HP/LT rocks were exhumed continuously and not episodically. We infer that HP/LT metamorphic rocks within the Halilbag?Complex were subjected to continuous return flow, with 'warm' rocks being exhumed during the tectonic burial of 'cold' ones. Our results, combined with regional geological constraints, allow us to speculate that subduction started at a transform fault near a mid-oceanic spreading centre. Following its formation, this ancient subduction interface evolved thermally over more than 15 Myr, most likely as a result of heat dissipation rather than crustal underplating. | Amaury Pourteau Erik E.Scherer Simon Schorn Rebecca Bast Alexander Schmidt Lisa Ebert | 2019 | Geoscience Frontiers2019，10，1： | 1 |
| 7 | Activating Connexin43 gap junctions primes adipose tissue for therapeutic intervention显示文摘Adipose tissue is a promising target for treating obesity and metabolic diseases.However,pharmacological agents usually fail to effectively engage adipocytes due to their extraordinarily large size and insufficient vascularization,especially in obese subjects.We have previously shown that during cold exposure,connexin43(Cx43)gap junctions are induced and activated to connect neighboring adipocytes to share limited sympathetic neuronal input amongst multiple cells.We reason the same mechanism may be leveraged to improve the efficacy of various pharmacological agents that target adipose tissue.Using an adipose tissue-specific Cx43 overexpression mouse model,we demonstrate effectiveness in connecting adipocytes to augment metabolic efficacy of theβ_(3)-adrenergic receptor agonist Mirabegron and FGF21.Additionally,combing those molecules with the Cx43 gap junction channel activator danegaptide shows a similar enhanced efficacy.In light of these findings,we propose a model in which connecting adipocytes via Cx43 gap junction channels primes adipose tissue to pharmacological agents designed to engage it.Thus,Cx43 gap junction activators hold great potential for combination with additional agents targeting adipose tissue. | Yi Zhu Na Li Mingyang Huang Xi Chen Yu AAn Jianping Li Shangang Zhao Jan-Bernd Funck Jianhong Cao Zhenyan He Qingzhang Zhu Zhuzhen Zhang Zhao VWang Lin Xu Kevin W.Williams Chien Li Kevin Grove Philipp E.Scherer | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 0 |
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