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| 1 | Harnessing male germline epigenomics for the genetic improvement in cattle显示文摘Sperm is essential for successful artificial insemination in dairy cattle,and its quality can be influenced by both epi-genetic modification and epigenetic inheritance.The bovine germline differentiation is characterized by epigenetic reprogramming,while intergenerational and transgenerational epigenetic inheritance can influence the offspring’s development through the transmission of epigenetic features to the offspring via the germline.Therefore,the selec-tion of bulls with superior sperm quality for the production and fertility traits requires a better understanding of the epigenetic mechanism and more accurate identifications of epigenetic biomarkers.We have comprehensively reviewed the current progress in the studies of bovine sperm epigenome in terms of both resources and biological discovery in order to provide perspectives on how to harness this valuable information for genetic improvement in the cattle breeding industry. | Xiao Wang Wenlong Li Xia Feng Jianbin Li George E.Liu Lingzhao Fang Ying Yu | 2023 | Journal of Animal Science and Biotechnology2023，14，5： | 1 |
| 2 | Influence of substrate composition on the formation of phytic acid conversion coatings显示文摘 | X.Cui G.Jin E.Liu M.Ding Q.Li F.Wang | 2012 | Materials and Corrosion2012，，3： | 1 |
| 3 | A Strong Stability-Preserving Predictor-Corrector Method for the Simulation of Elastic Wave Propagation in Anisotropic Media显示文摘In this paper,we propose a strong stability-preserving predictor-corrector(SSPC)method based on an implicit Runge-Kutta method to solve the acoustic-and elastic-wave equations.We first transform the wave equations into a system of ordinary differential equations(ODEs)and apply the local extrapolation method to discretize the spatial high-order derivatives,resulting in a system of semi-discrete ODEs.Then we use the SSPC method based on an implicit Runge-Kutta method to solve the semi-discrete ODEs and introduce a weighting parameter into the SSPC method.On top of such a structure,we develop a robust numerical algorithm to effectively suppress the numerical dispersion,which is usually caused by the discretization of wave equations when coarse grids are used or geological models have large velocity contrasts between adjacent layers.Meanwhile,we investigate the performance of the SSPC method including numerical errors and convergence rate,numerical dispersion,and stability criteria with different choices of the weighting parameter to solve 1-D and 2-D acoustic-and elastic-wave equations.When the SSPC is applied to seismic simulations,the computational efficiency is also investigated by comparing the SSPC,the fourth-order Lax-Wendroff correction(LWC)method,and the staggered-grid(SG)finite differencemethod.Comparisons of synthetic waveforms computed by the SSPC and analytic solutions for acoustic and elastic models are given to illustrate the accuracy and the validity of the SSPCmethod.Furthermore,several numerical experiments are conducted for the geological models including a 2-D homogeneous transversely isotropic(TI)medium,a two-layer elastic model,and the 2-D SEG/EAGE salt model.The results show that the SSPC can be used as a practical tool for large-scale seismic simulation because of its effectiveness in suppressing numerical dispersion even in the situations such as coarse grids,strong interfaces,or high frequencies. | D.H.Yang N.Wang E.Liu | 2012 | Communications in Computational Physics2012，12，9： | 0 |
| 4 | Genetic assessment of inbred chicken lines indicates genomic signatures of resistance to Marek's disease显示文摘Background: Marek's disease(MD) is a highly contagious pathogenic and oncogenic disease primarily affecting chickens. However, the mechanisms of genetic resistance for MD are complex and not fully understood. MD-resistant line 6_3 and MD-susceptible line 7_2 are two highly inbred progenitor lines of White Leghorn. Recombinant Congenic Strains(RCS) were developed from these two lines, which show varied susceptibility to MD.Results: We investigated genetic structure and genomic signatures across the genome, including the line 6_3 and line7_2, six RCSs, and two reciprocally crossed flocks between the lines 6_3 and 7_2(F1 6_3× 7_2 and F1 7_2× 6_3) using Affymetrix~? Axiom~? HD 600 K genotyping array. We observed 18 chickens from RCS lines were specifically clustered into resistance sub-groups distributed around line 6_3. Additionally, homozygosity analysis was employed to explore potential genetic components related to MD resistance, while runs of homozygosity(ROH) are regions of the genome where the identical haplotypes are inherited from each parent. We found several genes including SIK, SOX1, LIG4, SIK1 and TNFSF13B were contained in ROH region identified in resistant group(line 6_3 and RCS), and these genes have been reported that are contribute to immunology and survival. Based on F_(ST) based population differential analysis, we also identified important genes related to cell death and anti-apoptosis, including AKT1, API5, CDH13, CFDP and USP15,which could be involved in divergent selection during inbreeding process.Conclusions: Our findings offer valuable insights for understanding the genetic mechanism of resistance to MD and the identified genes could be considered as candidate biomarkers in further evaluation. | Lingyang Xu Yanghua He Yi Ding George E.Liu Huanmin Zhang Hans H.Cheng Robert L.Taylor Jr. Jiuzhou Song | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 0 |
| 5 | Recent progress on Majorana in semiconductor-superconductor heterostructures—engineering and detection显示文摘Majorana zero modes(MZMs)are exotic excitations(in condensed matter systems)of fundamental scientific interest and hold great promise as the basis of fault-tolerant topological quantum computation.Though MZMs have been predicted in many platforms,their existence is still under debate.In this paper,we review the recent progress in engineering and detecting MZMs in semiconductor-superconductor heterostructures.We also briefiy review the protocols for implementing topological quantum computation by hybrid semiconductor-superconductor nanowires. | Zhan Cao Shumeng Chen Gu Zhang Dong E.Liu | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，6： | 0 |
| 6 | Controllable Majorana vortex states in iron-based superconducting nanowires显示文摘To reve al the non-Abelian braiding statistics of Major ana zero modes(MZMs),it is crucial to design a Majorana platform,in which MZMs can be easily manipulated in a broad topological nontrivial parameter space.This is also an essential step to confirm their existence.In this study,we propose an iron-based superconducting nanowire system with Majorana vortex states to satisfy desirable conditions.This system has a radius-induced topological phase transition,giving a lower bound for the nanowire radius.In the topological phase,the iron-based superconducting nanowires have only one pair of MZMs over a wide range of radii,chemical potential and external magnetic fields.The wave function of MZMs has a sizable distribution at the side edge of the nanowires.This property enables the control of the interaction of MZMs in neighboring vortex nanowires and paves the way for Majorana fusion and braiding. | Chuang Li Xun-Jiang Luo Li Chen Dong E.Liu Fu-Chun Zhang Xin Liu | 2022 | National Science Review2022，9，9： | 0 |
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