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1Feasibility and safety of cryoballoon ablation for atrial fibrillation inpatients with congenital heart disease显示文摘BACKGROUND The prevalence of atrial fibrillation (AF) is on the rise in the aging population with congenital heart disease (CHD). A few case series have described the feasibility and early outcomes associated with radiofrequency catheter ablation of AF centered on electrically isolating pulmonary veins (PV) in patients with CHD. In contrast, cryoballoon ablation has not previously been studied in this patient population despite its theoretical advantages, which include a favorable safety profile and shorter procedural time. AIM To assess the safety and feasibility of cryoballoon ablation for AF in an initial cohort of patients with CHD. METHODS The study population consisted of consecutive patients with CHD and cryoballoon ablation for AF at the Montreal Heart Institute between December 2012 and June 2017. Procedural complications, acute success, and 1-year freedom from recurrent AF after a single procedure with or without antiarrhythmic drugs were assessed. Procedures were performed under conscious sedation. Left atrial access was obtained via a single transseptal puncture or through an existing atrial septal defect (ASD). Cryoballoon occlusion was assessed by distal injection of 50% diluted contrast into the pulmonary vein. At least one 240-second cryothermal application was performed upon obtaining complete pulmonary vein occlusion. Following ablation, patients were routinely followed at outpatient visits at 1, 3, 6, and 12 mo, and then annually. RESULTS Ten patients, median age 57.9 (interquartile range 48.2-61.7) years, 60% female, met inclusion criteria and were followed for 2.8 (interquartile range 1.4-4.5) years.Two had moderately complex CHD (sinus venosus ASD with partial anomalous pulmonary venous return;aortic coarctation with a persistent left superior vena cava), with the remainder having simple defects. AF was paroxysmal in 8 (80.0%) and persistent in 2 (20.0%) patients. The pulmonary vein anatomy was normal in 6 (60.0%) patients. Four had left common PV (n = 3) and/or 3 right PV (n = 2). Electrical pulmonary vein isolation (PVI) was acutely successful in all. One patient had transient phrenic nerve palsy that recovered during the intervention. No major complication occurred. One year after a single ablation procedure, 6 (60%) patients remained free from AF. One patient with recurrent AF had recovered pulmonary vein conduction and underwent a second PVI procedure. A second patient had ablation of an extra-pulmonary vein trigger for AF. CONCLUSION Cryoballoon ablation for AF is feasible and safe in patients with simple and moderate forms of CHD, with an excellent acute success rate and modest 1-year freedom from recurrent AF.Sylvia Abadir Victor Waldmann Katia Dyrda Mikael Laredo Blandine Mondésert Marc Dubuc Paul Khairy 2019World Journal of Cardiology2019,11,5:3
2Effects of elevated intracellularcalcium on the osmotic fragility of human red blood cells 显示文摘Cueff A Seear R Dyrda A 2010CellCalcium2010,47,1:1
3Influence of Steroid Therapy on the Incidence of Pericarditis and Atrial Fibrillation Following Percutaneous Epicardial Mapping and Ablation for Ventricular Tachyeardia显示文摘Dyrda K Piers SR Van Huls van Taxis CF 2014Circ Arrhythm Electrophysiol2014,7,4:1
4Mechanisms of VIP-induced inhibition of the lymphatic vessel pump显示文摘von der Weid PY Rehal S Dyrda P 0,,11:1
5Acute response of airway muscle to extreme temperature includes disruption of aetin-myosin interaction显示文摘Dyrda P Tazzeo T Doharris L 2011Am J Respir Cell Mol Biol2011,44,2:1
6Critical loads and effective frictional force mea- surements in the industrial scratch testing of TiN on M2 tool steel 显示文摘Dyrda K Sayer M 1999ThinSolidFilms1999,355,:1
7Myocardial bridging and milking effed of the left anterior descending artery:normal variant or obstruction显示文摘Nobel J Bourass MG Petickerck Dyrda I 1996Am J Cardiol1996,37,:1
8Influence of Steroid Therapy on the Incidence of Pericarditis and Atrial Fibrillation After Percutaneous Epicardial Mapping and Ablation for Ventricular Taehyeardia 显示文摘Dyrda K Piers SR van Huls van Taxis CF 2014Circ Arrhythm Electrophysiol2014,7,4:1
9Effects of elevated intracellular calcium on the osmotic fragility of human red blood cells显示文摘Cueff A Seear R Dyrda A 2010Cell Calcium2010,47,1:1
10Local membrane deformations activate Ca^2+-dependent K^+ and anionic currents in intact human red blood cells显示文摘Dyrda A Cytlak U Ciuraszkiewicz A 2010PLos One2010,5,2:1
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