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| 1 | 中国人多吃水果可降低心血管疾病风险显示文摘在2004年至2008年,来自牛津大学和中国医学科学院的研究人员招募了512891名30-79岁成人,他们来自中国10个不同的地区。研究长达7年,经过320万人年的随访,在基线没有心血管病史或降压治疗的451665名参与者中,共发生5173例心血管疾病死亡事件,2551例主要冠脉事件(致命性或非致命性),14579例缺血性卒中事件,3523例脑内出血事件。研究人员利用Cox回归计算出新鲜水果消耗与发病率之间的调整后危险比。 | Du H Li L Bennett D | 2016 | 甘肃医药2016，35，4： | 27 |
| 2 | Beginning to understand microRNA function显示文摘MicroRNAs (miRNAs ) 是小 RNA 由植物,动物,病毒和至少一个单细胞的有机体表示了的 -22 nt,绿水藻, Chlamydomonas reinhardtii [1 ] 。MostmiRNAs 被 RNA II 作为主要 miRNAs (pri-miRNAs ) 抄录,尽管一些被 RNA III 抄录。在动物, pri-miR-NAs 被二连续 endonucleolytic 劈开变换成成熟 miRNAs [2 ] 。pri-miRNA 被 Drosha 首先切成原子核, aribonuclease III (RNase III ) 酶,与它的双 stranded 扮演 RNA 有约束力的领域(dsRBD ) 蛋白质搭挡,在脊椎动物的叫的 DGCR8 和在无脊椎动物的帕夏进一个 -70 nt 茎环,先锋 miRNA (pre-miRNA ) 。在它到由 Exportin 5 的细胞质的出口以后, pre-miRNA 是到由第二 RNase III 酶的成熟 miRNA 的角质, Dicer,哪个在有 twodsRBD 蛋白质之一的哺乳动物的搭挡—TRBP (HIV-1 焦油 RNA 有约束力的蛋白质) 或合同,或在有 thedsRBD 蛋白质的果蝇 melanogaster 多话(Loqs ) 。成熟 miRNA 然后被装进一个受动器复杂、导致 theRNA 的 silencing 建筑群(RISC ) ,其核心部件总是是 Argonaute 的一个成员(以前)指导 RNA 的 RNA 规章的蛋白质的家庭[3 ] 。最近,一条其他的处理小径在果蝇和 C 为 miRNAs 的不同亚群被识别。elegans [4, 5 ] 。这些 miRNAsexploit 拼接的 pre-mRNA 直接产生 pre-miRNA 的机械,绕过由 Drosha 处理 pri-miRNA。为这些 miRNAs, pre-miRNA 是马上成熟 miRNAand 的先锋紧缩的、充分功能的 intron,因此名字,“ mirtrons ”。 | Tingting Du Phillip D Zamore | 2007 | Cell Research2007，17，8： | 20 |
| 3 | Preoperative rectosigmoid endoscopic ultrasonography predicts the need for bowel resection in endometriosis显示文摘BACKGROUND Rectosigmoid endometriosis is an underdiagnosed disease responsible for abdominal pain, transit disorders and rectal bleeding. Two surgical approaches,rectosigmoid bowel resection(segmental or patch) or intramuscular layer dissection(shaving), are available.AIM To assess whether the lesion features observed via preoperative rectosigmoid endoscopic ultrasonography(RS-EUS) might predict the need for bowel resection.METHODS This multicentric retrospective study was conducted on patients with rectosigmoid endometriosis who underwent a curative surgical procedure,evaluated by RS-EUS performed by two trained operators, between January 2012 and March 2018. A univariate statistical analysis was performed on nodules' RSEUS features(thickness, width, infiltration of the submucosae, presence of a bump into the digestive lumen and presence of multiple rectosigmoid localizations). A multivariate logistic regression was then performed on the significant results.RESULTS Of the 367 patients, 73 patients with rectosigmoid endometriosis were evaluated by RS-EUS and underwent rectosigmoid surgery. After the univariate analysis was completed, thickness, width and infiltration of the submucosae were identified as potential predictive factors for bowel resection. In a multivariate logistic regression model, only thickness appeared to be a significant [odds ratio(OR) = 1.49, 95% confidence interval(CI): 1.04-2.12, P = 0.028] predictive factor for bowel resection. Receiver operating characteristic analysis performed showed that a thickness over 5.20 mm might be used as cut-off with a sensitivity of 76%, a specificity of 81%, and an area under carve = 0.82. The cut-off values for 100%sensitivity and 100% specificity were 0.90 mm and 10.00 mm, respectively. A trend concerning width to predict the need for resection was also observed(OR1.12, 95%CI: 1.00-1.26, P = 0.054)CONCLUSION The presence of a rectosigmoid nodule of endometriosis greater than 5.20 mm thick on RS-EUS might predict the need for bowel resection. | Victor Desplats René-Louis Vitte Joseph du Cheyron Gilles Roseau Arnaud Fauconnier Frédérick Moryoussef | 2019 | World Journal of Gastroenterology2019，25，6： | 9 |
| 4 | Effects of somatostatin on splanchnic hemodynamics in cirrhotic patients with portal hypertension显示文摘INTRODUCTIONEsophageal variceal bleeding (EVB) is one of themost common complications of cirrhosis with portalhypertension.In recent years,great progress hasbeen made in medicinal treatment.Somatostatin hasbeen widely used in clinics,for it can effectivelylower the portal venous pressure (PVP) with | Zhu JY Leng XS Wang D Du RY | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 5 | 巨峰和无核早红葡萄在越南谅山试种观察显示文摘[目的]观察巨峰、无核早红葡萄在越南谅山省的引种表现,为其在越南推广种植提供参考依据.[方法]2009年春从中国南宁引入巨峰、无核早红两个鲜食葡萄品种在越南谅山省试种,调查其枝蔓生长量、物候期、果实性状、产量等相关指标.[结果]至第1年抚育冬季,巨峰葡萄枝蔓总长234.5 cm,上架茎粗0.84 cm;无核早红葡萄枝蔓总长294.1 cm,上架茎粗0.86 cm.在物候期方面,巨峰葡萄从萌芽至果实成熟需141~151 d,表现中熟;无核早红从萌芽至果实成熟需142~151 d,未表现其应有的早熟特性.在果实性状方面,巨峰葡萄2010~2012年3年平均单果重8.9 g,种子数1.04粒,可溶性固形物(TSS)含量17.5%;无核早红葡萄2010~2012年3年平均单果重6.8 g,TSS含量13.9%.在产量方面,巨峰葡萄2010~2012年产量分别为13.69、17.50和16.24 t/ha;无核早红葡萄2010~2012年产量分别为10.81、16.02和20.92t/ha.[结论]巨峰葡萄在越南谅山省种植表现丰产稳产优质,具有较好的适栽性,可大面积推广种植;无核早红葡萄表现丰产稳产,但表现低糖低酸,极易裂果,着色困难,不宜在越南大面积发展. | 黄江流 PHAM Thi Thang 罗瑞鸿 NGUYN Thi Hà 吕荣华 LUONG Dǎng Ning CHU Vǎn DUòng NGUYN Manh Tòng 彭宏祥 Ly Ming Nguyet LU'O'NG i Thuy CHU Xun Tien VI Vǎn Dúc NGUYN Duy Dng Ly Dúc Khiêm 熊俏 | 2014 | 南方农业学报2014，45，7： | 5 |
| 6 | Plasma and platelet serotonin levels in patients with liver cirrhosis显示文摘AIM: To analyze the relationship between plasma and platelet serotonin levels and the degree of liver insufficiency. METHODS: The prospective study included 30 patients with liver cirrhosis and 30 healthy controls. The degree of liver failure was assessed according to the Child-Pugh classification. Platelet and platelet poor plasma serotonin levels were determined. RESULTS: The mean plasma serotonin level was higher in liver cirrhosis patients than in healthy subjects (215.0 ± 26.1 vs 63.1 ± 18.1 nmol/L; P < 0.0001). The mean platelet serotonin content was not significantly different in patients with liver cirrhosis compared with healthy individuals (4.8 ± 0.6; 4.2 ± 0.3 nmol/platelet; P > 0.05). Plasma serotonin levels were significantly higher in Child- Pugh grade A/B than in grade C patients (246.8 ± 35.0 vs 132.3 ± 30.7 nmol/L; P < 0.05). However, platelet serotonin content was not significantly different between Child-Pugh grade C and grade A/B (4.6 ± 0.7 vs 5.2 ± 0.8 nmol/platelet; P > 0.05). CONCLUSION: Plasma serotonin levels are significantly higher in patients with cirrhosis than in the controls and represent the degree of liver insufficiency. In addition, platelet poor plasma serotonin estimation is a better marker for liver insufficiency than platelet serotonin content. | ■or■e M ulafi Duko S Mirkovi Miodrag D Vukevi Jelena S Rudi | 2007 | World Journal of Gastroenterology2007，13，43： | 5 |
| 7 | Genome resequencing and transcriptome profiling reveal structural diversity and expression patterns of constitutive disease resistance genes in Huanglongbing-tolerant Poncirus trifoliata and its hybrids显示文摘Huanglongbing(HLB)is the most destructive bacterial disease of citrus worldwide.While most citrus varieties are susceptible to HLB,Poncirus trifoliata,a close relative of Citrus,and some of its hybrids with Citrus are tolerant to HLB.No specific HLB tolerance genes have been identified in P.trifoliata but recent studies have shown that constitutive disease resistance(CDR)genes were expressed at much higher levels in HLB-tolerant Poncirus hybrids and the expression of CDR genes was modulated by Candidatus Liberibacter asiaticus(CLas),the pathogen of HLB.The current study was undertaken to mine and characterize the CDR gene family in Citrus and Poncirus and to understand its association with HLB tolerance in Poncirus.We identified 17 CDR genes in two citrus genomes,deduced their structures,and investigated their phylogenetic relationships.We revealed that the expansion of the CDR family in Citrus seems to be due to segmental and tandem duplication events.Through genome resequencing and transcriptome sequencing,we identified eight CDR genes in the Poncirus genome(PtCDR1-PtCDR8).The number of SNPs was the highest in PtCDR2 and the lowest in PtCDR7.Most of the deletion and insertion events were observed in the UTR regions of Citrus and Poncirus CDR genes.PtCDR2 and PtCDR8 were in abundance in the leaf transcriptomes of two HLB-tolerant Poncirus genotypes and were also upregulated in HLB-tolerant,Poncirus hybrids as revealed by real-time PCR analysis.These two CDR genes seem to be good candidate genes for future studies of their role in citrus-CLas interactions. | Nidhi Rawat Brajendra Kumar Ute Albrecht Dongliang Du Ming Huang Qibin Yu Yi Zhang Yong-Ping Duan Kim D Bowman Fred G Gmitter Jr Zhanao Deng | 2017 | Horticulture Research2017，4，1： | 5 |
| 8 | Analysis of CO_2 utilization into synthesis gas based on solar thermochemical CH_4-reforming显示文摘In this study, the solar thermochemical reactor performance for CO_2 utilization into synthesis gas(H_2+ CO) based on CH_4 reforming process was investigated in the context of carbon capture and utilization(CCU) technologies. The P1 radiation heat transfer model is adopted to establish the heat and mass transfer model coupled with thermochemical reaction kinetics. The reactor thermal behavior with direct heat transfer between gaseous reactant and products evolution and the effects of different structural parameters were evaluated. It was found that the reactor has the potential to utilize by ~60% of CO_2 captured with 40% of CH_4 co-fed into syngas(72.9% of H_2 and 27.1% of CO) at 741.31 k W/mof incident radiation heat flux. However, the solar irradiance heat flux and temperature distribution were found to significantly affect the reactant species conversion efficiency and syngas production. The chemical reaction is mainly driven by the thermal energy and higher species conversion into syngas was observed when the temperature distribution at the inner cavity of the reactor was more uniform. Designed a solar thermochemical reactor able to volumetric store concentrated irradiance could highly improve CCU technologies for producing energy-rich chemicals. Besides, the mixture gas inlet velocity, operating pressure and CO_2/CH_4 feeding ratio were crucial to determining the efficiency of CO_2 utilization to solar fuels. Catalytic CO_2-reforming of CH_4 to chemical energy is a promising strategy for an efficient utilization of CO_2 as a renewable carbon source. | Bachirou Guene Lougou Yong Shuai Gédéon Chaffa Huang Xing Heping Tan Huibin Du | 2019 | Journal of Energy Chemistry2019，28，1： | 4 |
| 9 | Distortion control of conjugacies between quadratic polynomials显示文摘We use a new type of distortion control of univalent functions to give an alternative proof of Douady-Hubbard’s ray-landing theorem for quadratic Misiurewicz polynomials. The univalent maps arise from Thurston’s iterated algorithm on perturbation of such polynomials. | CUI GuiZhen 1, & TAN Lei 2 1 Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China 2 Laboratoire de Mathmatiques, UMR du CNRS 6093, Universit d’Angers, 2 bd. Lavoisier, 49045 Angers cedex 01, France | 2010 | Science China Mathematics2010，53，3： | 3 |
| 10 | Clinical use of genotype to predict chemosensitivity in oligodendroglial tumors显示文摘 | Walker C Haylock B Husband D Joyce KA Fildes D Jenkirtson MD Smith T Broome J du Plessis DG Warnke PC | 2006 | 中国神经肿瘤杂志2006，4，3： | 2 |
| 11 | Serum amyloid P component and C-reactive protein mediate phagocytosis through murine FcγRs显示文摘 | Mold C Gresham H D Du Clos T W | 2001 | J Immunol2001，166，： | 2 |
| 12 | Optimization of wavelength assignment for QoS multicast in WDM networks 显示文摘 | JIA X DU D HU X | 2001 | IEEE Transactions Communications2001，49，2： | 1 |
| 13 | Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage 显示文摘 | Nishikawa T Edelstein D Du XL | 2000 | Nature2000，404，6779： | 1 |
| 14 | Prediction of beef eating qualities from colour, marbling and wavelet surface texture features using homogenous carcass treatment显示文摘 | Jackman P Sun D W Du C J P | 2009 | Pattern Recognition2009，42，5： | 1 |
| 15 | Study on LD-VHDL conversion for FPGA-based PLC implementation显示文摘 | DU D LIU Y GUO Y etc | 2009 | Int J Adv Manuf Techol2009，40，1112： | 1 |
| 16 | miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells 显示文摘 | Xia L Zhang D Du R | 2008 | Int J Cancer2008，123，2： | 1 |
| 17 | Evaluation of the California mastitls test as a precalving treatment selection tool for Holstein heifers显示文摘 | Roy J P Du Tremblay D Descoteaux L | 2009 | Vet Microbiol2009，134，12： | 1 |
| 18 | Electro-optically Q-switched Ndz YVO4 slab laser with a high repetition rate and a short pulse width显示文摘 | DU K M LI D J ZHANG H L etal | 2003 | Optics Letters2003，28，2： | 1 |
| 19 | Unexpected population inversion via spontaneously generated coherence of a Λ system显示文摘 | Gong S Q Li Y Du S D | 1999 | Phys Lett1999，259，1： | 1 |
| 20 | Synthesis, Spectroscopic and Electrochemical Properties of Rare Earth Double - Deckers with Tetra(tert - butyl) - 2,3 -naphthalocyaninato Ligands 显示文摘 | J Jiang W Liu K- W Poon D Du D P Arnold DKPNg | 2000 | Euro J Inorg Chem2000，205，： | 1 |
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