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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Experimental autoimmuneence phalitis and inflammation in the absence of interleukin-12显示文摘 | Bercher B Durell BG Noelle RJ | 2002 | J Clin Invest2002，110，4： | 1 |
| 3 | Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12显示文摘 | Becher B Durell BG Noelle RJ | 2002 | J Clin Invest2002，110，： | 1 |
| 4 | Gamma delta T cell - deficient mice have a down- regulated CD8 + t cell immune response against Encephalitozoon cuniculi infection显示文摘 | Moretto M Durell B Schwartzman JD | 2001 | Junl52001，166，12： | 1 |
| 5 | Experimental autoimmune ence-phalitis and inflammation in the absence of interleukin-12显示文摘 | Becher B Durell BG Noelle RJ | 2002 | J Clin Invest2002，110，： | 1 |
| 6 | Hepcidin targets ferroportin for degradation in hepatocytes 显示文摘 | Ramey G Deschemin JC Durel B | 2010 | Haematologica2010，95，3： | 1 |
| 7 | Iron overload in Hepcl (-/-) mice is not impairing glucose homeostasis显示文摘 | Ramey G Faye A Durel B | 2007 | FEBS Lett2007，581，5： | 1 |
| 8 | Hepcidin targets ferroportin for degradation in hepatocytes显示文摘 | Ramey G Deschemin JC Durel B | 2010 | Haematologica2010，95，： | 1 |
| 9 | Gamma delta T cell- deficient mice have a down regulated CD8^+T cell immune response against Encephalitozoon cuniculi infection 显示文摘 | Moretto M Durell B Schwartzman JD | 2001 | J Immunol2001，166，12： | 1 |
| 10 | Integrating spheres calibrate sensors显示文摘 | Jablonski J Durell C Schulman B | 2005 | Vision Systems Design2005，10，1： | 1 |
| 11 | Etanercept may induce neurosarcoidosis in a patient treated for rheumatoid aruftis显示文摘 | Durel C A Feurer E Pialat J B | 2013 | BMC Neurol2013，13，： | 1 |
| 12 | Gamma delta T celldeficient mice have a down regulated CD8^+ T cell immune response against Encephalitozoon cuniculi infection显示文摘 | Moretto M Durell B Schwartzman JD | 2001 | J Immunol2001，166，： | 1 |
| 13 | IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis显示文摘 | Becher B Durell BG Noelle RJ | 2003 | J Clin Invest2003，112，8： | 1 |
| 14 | Iron overload in Hepc1 mice is not impairing glucose homeostasis显示文摘 | Ramey G Faye A Durel B | 2007 | FEBS Lett2007，581，5： | 1 |
| 15 | Experimentalautoimmune encephalitis and inflammation in the absence of interleukin-12显示文摘 | BECHER B DURELL B G NOELLE R J | 2002 | J Clin Invest2002，110，4： | 1 |
| 16 | Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12显示文摘 | Becher B Durell BG Noelle RL | 2002 | J Clin Invest2002，110，： | 1 |
| 17 | Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12 显示文摘 | BECHER B DURELL B G NOELLE R J | 2002 | J Clin Invest2002，110，4： | 1 |
| 18 | Experimental autoimmune encephalitis and inflammation in the absence of interleukin - 12 显示文摘 | Becher B Durell BG Noelle RJ | 2002 | JClin Invest2002，110，： | 1 |
| 19 | IL -23 produced by CNS-resident Cells Controls T cell Encephalitogenicity During the Effector Phase of Experimental Autoimmune Encephalomyelitis显示文摘 | Becher B Durell BG Noelle RJ | 2003 | J Clin Invest(S0021-9738)2003，112，： | 1 |
| 20 | Gamma delta T cell-deficient mice have a down regulated CD8+ T cell immune response against Encephalitozoon cuniculi infection 显示文摘 | MORETTO M DURELL B SCHWARTZMAN J D | 2001 | J Immunol2001，166，： | 1 |
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