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507篇 您的检索式：作者名="Duchen"

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	题名	作者	年代	出处	被引量
1	Modelling mitochondrial dysfunction in Alzheimer’s disease using human induced pluripotent stem cells显示文摘Alzheimer’s disease (AD) is the most common form of dementia. To date, only five pharmacological agents have been approved by the Food and Drug Administration for clinical use in AD, all of which target the symptoms of the disease rather than the cause. Increasing our understanding of the underlying pathophysiology of AD will facilitate the development of new therapeutic strategies. Over the years, the major hypotheses of AD etiology have focused on deposition of amyloid beta and mitochondrial dysfunction. In this review we highlight the potential of experimental model systems based on human induced pluripotent stem cells (iPSCs) to provide novel insights into the cellular pathophysiology underlying neurodegeneration in AD. Whilst Down syndrome and familial AD iPSC models faithfully reproduce features of AD such as accumulation of Aβ and tau, oxidative stress and mitochondrial dysfunction, sporadic AD is much more difficult to model in this way due to its complex etiology. Nevertheless, iPSC-based modelling of AD has provided invaluable insights into the underlying pathophysiology of the disease, and has a huge potential for use as a platform for drug discovery.	Kate Elizabeth Hawkins Michael Duchen	2019	World Journal of Stem Cells2019，11，5：	5
2	Gastrointestinal hemorrhage as first manifestation of metastatic testicular tumor显示文摘	Shahrokh F. Shariat David Duchene Wareef Kabbani Zachary Mucher Yair Lotan	2005	Urology2005，，6：	2
3	Mitochondria in health and disease: perspectives on a new mitochondrial biology显示文摘	Michael R Duchen	2004	Molecular Aspects of Medicine2004，，4：	2
4	Roles of mitochondria in health and disease显示文摘	Duchen M R	2004	Diabetes2004，，：	1
5	Formulation of epichlo- rohydrin crosslinked starch microspheres显示文摘	HAMDI G PONCHEL G DUCHEN E D	2001	Journal of Microen- capsulation2001，18，3：	1
6	Entamoeba histolytica : i- dentification of thioredoxin-targeted proteins and analysis of serine acetyltransferase-1 as a prototype example显示文摘	Schlosser S Leitsch D Duchene M	2013	Biochem J2013，451，2：	1
7	An original method for studying in vitro the enzymatic degradation of cross-linked starch microspheres 显示文摘	Harndi G Ponchel G Duchene D	1998	Journal of Controlled Release1998，55，：	1
8	Survey of practicing urologists:Robotic versus open radical prostatectomy显示文摘	Lee EK Baack J Duchene DA	2010	Can J Urol2010，17，2：	1
9	A Model of EMG Generation显示文摘	DUCHEN E J HOGREL J Y	2000	IEEE Transact Biom Engineer2000，47，2：	1
10	Development of a new collidal drug carrier from chemicallymodified cyclodextrins :nanospheres, and influence ofphysicochemical and technological factors on particle size显示文摘	Skiba M Duchene D Puisieux F	1996	Int J Pharm1996，129，：	1
11	Glutamate-induced mitochondrial depolarization and perturbation of calcium homeostasis in cultured rat hippocampal neurons显示文摘	Vergun O Keelan J Khodorov B I Duchen M R	1999	Physiol1999，519，2：	1
12	Subjective Evaluation of Discomfort in Sitting Positions 显示文摘	Grabisch M Duchene J Lino F	2002	Fuzzy Optimization and Decision Making2002，1，3：	1
13	Inhibiting mitochondrial per- meability l ore opening at reperfusion protects against ischemia-reperfu- sion injury显示文摘	Hausenloy KJ Duchen MR Yellon DM	2003	Cardiovasc Res2003，60，3：	1
14	Grapevine and climatic changes: a glance at the situation in Alsace显示文摘	Duchene E Schneider C	2005	Agronomy for Sustainable Develooment2005，25，12：	1
15	The evolution of hard coal trade in the Atlantic market显示文摘	Ekawan R Duchene M	2006	Energy Policy2006，34，13：	1
16	Model identification and FE simulations: Effect of different yield loci and hardening laws in sheet forming显示文摘	Flores P Duchene L Bouffioux C	2007	International Journal of Plasticity2007，23，3：	1
17	A model of EMG generation 显示文摘	Duchen EJ Hogrel JY	2000	IEEE Trans Biomed Eng(S0018--9294)2000，47，2：	1
18	Mitochondria, Ca62+ and neurodegenerative disease显示文摘	KRIEGER C DUCHEN MR	2002	Eur J Pharmacol2002，447，23：	1
19	An original method for studying in vitro the enzymatic degradation of cross-linked starch microspheres显示文摘	Hamdi G Ponchel G Duchene D	1998	Journal of Con- trolled Release1998，55，23：	1
20	显示文摘	Hamdi G Ponchel G Duchene D	1998	Journal of Controlled Release1998，55，23：	1

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