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| 1 | Dual-mode dynamic window approach to robot navigation with convergence guarantees显示文摘In this paper,a novel,dual-mode model predictive control framework is introduced that combines the dynamic window approach to navigation with generic path planning techniques through a dual-mode model predictive control framework.The planned path adds information on the connectivity of the free space to the obstacle avoidance capabilities of the dynamic window approach.This allows for guaranteed convergence to a goal location while navigating through an unknown environment at relatively high speeds.The framework is applied in a combined simulation/hardware implementation to demonstrate the computational feasibility and the ability to cope with the constraints of a dynamic system. | Greg Droge | 2021 | Journal of Control and Decision2021，8，2： | 5 |
| 2 | Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation显示文摘AIM To investigate the relation of two different mutations to the outcome of partial external biliary diversion(PEBD)in severe bile salt export pump(BSEP) deficiency.METHODS Mutations in the gene encoding BSEP leading to severe BSEP deficiency in two unrelated patients were identified by genomic sequencing. Native liver biopsies and transiently transfected human embryonic kidney(HEK) 293 cells expressing either wild-type or mutated BSEP were subjected to immunofluorescence analysis to assess BSEP transporter localization. Bile acid profiles of patient and control bile samples were generated by ultra-performance liquid chromatographytandem mass spectrometry. Wild-type and mutant BSEP transport of [~3H]-labeled taurocholate(TC) and taurochenodeoxycholate(TCDC) was assessed by vesicular transport assays.RESULTS A girl(at 2 mo) presented with pruritus, jaundice and elevated serum bile salts(BS). PEBD stabilized liver function and prevented liver transplantation. She was heterozygous for the BSEP deletion p.T919 del and the nonsense mutation p.R1235 X. At the age of 17 years relative amounts of conjugated BS in her bile were normal, while total BS were less than 3% as compared to controls. An unrelated boy(age 1.5 years) presenting with severe pruritus and elevated serum BS was heterozygous for the same nonsense and another missense mutation, p.G1032 R. PEBD failed to alleviate pruritus, eventually necessitating liver transplantation. BS concentration in bile was about 5% of controls. BS were mainly unconjugated with an unusual low amount of chenodeoxycholate derivatives(< 5%). The patients' native liver biopsies showed canalicular BSEP expression. Both BSEP p.T919 del and p.G1032 R were localized in the plasma membrane in HEK293 cells. In vitro transport assays showed drastic reduction of transport by both mutations. Using purified recombinant BSEP as quantifiable reference, per-molecule transport rates for TC and TCDC were determined to be 3 and 2 BS molecules per wild-type BSEP transporter per minute, respectively.CONCLUSION In summary, our findings suggest that residual function of BSEP as well as substrate specificity influence the therapeutic effectiveness of PEBD in progressive familial intrahepatic cholestasis type 2(PFIC-2). | Philipp Ellinger Jan Stindt Carola Droge Katharina Sattler Claudia Stross Stefanie Kluge Diran Herebian Sander HJ Smits Martin Burdelski Sebastian Schulz-Jürgensen Antje Ballauff Jan Schulte am Esch Ertan Mayatepek Dieter Haussinger Ralf Kubitz Lutz Schmitt | 2017 | World Journal of Gastroenterology2017，23，29： | 4 |
| 3 | Continuous-time proportional-integral distributed optimisation for networked systems显示文摘In this paper,we explore the relationship between dual decomposition and the consensusbased method for distributed optimisation.The relationship is developed by examining the similarities between the two approaches and their relationship to gradient-based constrained optimisation.By formulating each algorithm in continuous-time,it is seen that both approaches use a gradient method for optimisation with one using a proportional control term and the other using an integral control term to drive the system to the constraint set.Therefore,a significant contribution of this paper is to combine these methods to develop a continuous-time proportional-integral distributed optimisation method.Furthermore,we establish convergence using Lyapunov stability techniques and utilising properties from the network structure of the multi-agent system. | Greg Droge Hiroaki Kawashima Magnus B.Egerstedt | 2014 | Journal of Control and Decision2014，1，3： | 3 |
| 4 | Strateegic logistics capabilities for competitive advantage and firm success显示文摘 | Morash E Droge C Vickery S | 1996 | Ournal of Business Logistics1996，17，1： | 1 |
| 5 | Relationship organization:alternatives and costs显示文摘 | Vicky S Droge C Germain R | 1999 | Journal of Operation Management1999，17，4： | 1 |
| 6 | The effects of internal ver- sus external integration practices on time-based perfor- mance and overall firm performance 显示文摘 | Droge C Jayaram J Vickery S K | 2004 | Journal of Opera- tions Management2004，22，6： | 1 |
| 7 | The bile salt export pump (BSEP) in health and disease 显示文摘 | Kubitz R Droge C Stindt L | 2012 | Clin Res Hepatol Gastroenterol2012，36，6： | 1 |
| 8 | Free redicals in the physiological control of cell function显示文摘 | Droge W | 2002 | Physiol Rev2002，82，1： | 1 |
| 9 | Free radicals in the physilolgical control of cell function 显示文摘 | DROGE W | 2002 | Physiol Revi2002，82，1： | 1 |
| 10 | Drug induced acute pancreatitis:incidence and severity 显示文摘 | Lankisch PG Droge M Gottesleben F | 1995 | Gut1995，37，4： | 1 |
| 11 | Does product platform strategy mediate the effects of supply chain integration on performance? A dynamic capabilities perspective显示文摘 | VICKERY S K KOUFTEROS X DROGE C | 2013 | IEEE Transactions on Engineering Management2013，60，4： | 1 |
| 12 | Production competence and business strategy: do they affect business performance 显示文摘 | Vickery S Droge C Markland RE | 1993 | Decision Sciences1993，24，2： | 1 |
| 13 | Free radicals in the physiological control of cell function显示文摘 | Droge W | 2002 | Physiol Rev2002，82，： | 1 |
| 14 | The Effects of An Integrative Supply Chain Strategy on Customer Service and Financial Performance:An Analysis of Direct Versus Indirect Relationship显示文摘 | Vichery S.K Jayaram J Droge C Calantone R | | 0，，： | 1 |
| 15 | The Effects of Internal Versus External Integration Practices on Time-Based Performance and Overall Firm Performance显示文摘 | DROGE C JAYARAM J VICKERY S K | 2004 | Journal of Operations Man agement2004，22，6： | 1 |
| 16 | Strategic logistics capabilities for competitive advantage andfirm success 显示文摘 | Edward A Morash Conelia L M Droge Shawnee K Vickery | 1996 | Journal of Business Logistics1996，，： | 1 |
| 17 | The design of logistics organizations显示文摘 | RICHARD G | 1998 | Logistics and Transportation Review1998，34，1： | 1 |
| 18 | The relationship between product customisation and organizational structure 显示文摘 | Vickery S C Droge R Germain | 1999 | Journal of Operations Management1999，，17： | 1 |
| 19 | The effects of intemalve- rsus external integration practices on time-based perform- ance and overall firm performance显示文摘 | Droge C Jayaram J Vickery S | 2004 | Journal of Operations Management2004，22，6： | 1 |
| 20 | Free radicals in the physiological control of cell function显示文摘 | Droge W | 2002 | Physiological Reviews2002，82，1： | 1 |
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