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| 1 | Current progress in use of adipose derived stem cells in peripheral nerve regeneration显示文摘Unlike central nervous system neurons; those in the peripheral nervous system have the potential for full regeneration after injury. Following injury, recovery is controlled by schwann cells which replicate and modulate the subsequent immune response. The level of nerve recovery is strongly linked to the severity of the initial injury despite the significant advancements in imaging and surgical techniques. Multiple experimental model shave been used with varying successes to augment the natural regenerative processes which occur following nerve injury. Stem cell therapy in peripheral nerve injury may be an important future intervention to improve the best attainable clinical results. In particular adipose derived stem cells(ADSCs) are multipotent mesenchymal stem cells similar to bone marrow derived stem cells, which are thought to have neurotrophic properties and the ability to differentiate into multiple lineages. They are ubiquitous within adipose tissue; they can form many structures resembling the mature adult peripheral nervous system. Following early in vitro work; multiple small and large animal in vivo models have been used in conjunction with conduits, autografts and allografts to successfully bridge the peripheral nerve gap. Some of the ADSC related neuroprotective and regenerative properties have been elucidated however much work remains before a model can be used successfully in human peripheral nerve injury(PNI). This review aims to provide a detailed overview of progress made in the use of ADSC in PNI, with discussion on the role of a tissue engineered approach for PNI repair. | Shomari DL Zack-Williams Peter E Butler Deepak M Kalaskar | 2015 | World Journal of Stem Cells2015，7，1： | 8 |
| 2 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 3 | In vitro corneal pathogenicity of Acanthamoeba显示文摘 | Larkin DF Berry M Easty DL | 1991 | Eye1991，5，5： | 1 |
| 4 | Enlarged frontal P300 to stimulus change in panic disorder显示文摘 | McFarlane AC Weber DL Battersby M | 1996 | Biol Psychiatry1996，39，10： | 1 |
| 5 | The SCL-90 factor structure in comorbid substance abusers显示文摘 | Zack M Toneatto T Streiner DL | 1998 | J Subst Abuse1998，10，1： | 1 |
| 6 | The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma显示文摘 | Rosenstreich DL Eggleston P Kattan M | 1997 | N Engl J Med1997，336，： | 1 |
| 7 | Expression and regu-lation of aggrecanase in arthritis:the role of TGF-beta 显示文摘 | Yamanishi Y Boyle DL Clark M | 2002 | J Immunol2002，168，3： | 1 |
| 8 | Is mutated MTHFR a risk factor for neural tube defects显示文摘 | Posey DL Khoury M J Mulinare J | 1996 | Lancet1996，347，： | 1 |
| 9 | An Australian experience with Temozolomide for the treatment of recurrent high-grade gliomas显示文摘 | Harris M T Rosenthal MA Ashley DL | 2001 | J Clin Neurosci2001，8，： | 1 |
| 10 | Preva lence of human T cell lymphotropic virus type 1 infection in hospi talized patients with tuberculosis显示文摘 | De Lourdes Bastos M Osterbauer B Mesquita DL | 2009 | Int J Tuberc Lung Dis2009，13，12： | 1 |
| 11 | Quality of life and the cancer ex- pefince : the state of the knowledge 显示文摘 | King CR Habeman M Berry DL | 2007 | Oncol Nursi Forum2007，24，： | 1 |
| 12 | Production of infectious genotype la hepatitis C virus(Hutchinson strain) in cultured human hepatoma cells显示文摘 | Yi M Villanueva RA Thomas DL | | 0，，： | 1 |
| 13 | Bclo2 genes promotes heamopoietic cells survival and cooperates with C-myc to immortalize pro-B cell 显示文摘 | Vaux DL Cory S Adams M | 1998 | Nature1998，335，6189： | 1 |
| 14 | Early diagnosis of clinically significant hyperfibrinolysis using thrombelastography velocity curves 显示文摘 | Pommerening M J Goodman MD Farley DL | 2014 | J Am Coll Surg2014，219，6： | 1 |
| 15 | Differential effects of paricalcitol and calcitriol on intestinal calcium absorption in hemodialysis patients显示文摘 | Lund RJ Andress DL Amdahl M | 2010 | Am J Nephrol2010，31，2： | 1 |
| 16 | Effects of feanfibrate and ezetimibe, both as monotherapy and in coadministration, on cholesterol mass within lipoprotein subfractions and low-density lipeprotein peak particle size in patients with mixed hyperlipidemia 显示文摘 | Tribble DL Farnier M Macdonell G | 2008 | Metabolism2008，57，6： | 1 |
| 17 | Chimeric antigen receptormodified T cells in chronic lymphoid leukemia 显示文摘 | Porter DL Levine BL Kalos M | 2011 | N Engl J Med2011，365，8： | 1 |
| 18 | Inhibition of autophagy promotes cell apoptosis induced by the proteasome inhibitor MG-132 in human esophageal squamous cell carcinoma EC9706 cells 显示文摘 | Liu DL Gao M Yang Y | 2015 | Oncol Lett2015，9，5： | 1 |
| 19 | Increased tissue kallikrein levels in type 2 di- abetes显示文摘 | CAMPBELL DJ KLADIS A ZHANG Y JENKINS AJ PRIOR DL YH M | 2010 | Diabetologia2010，53，4： | 1 |
| 20 | Clinical features of the failed-back syndrome显示文摘 | Filtzer DL BenDebba M | 1988 | J Neurosurg1988，69，： | 1 |
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