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54篇 您的检索式：作者名="Doucet L"

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	题名	作者	年代	出处	被引量
1	The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients.	Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens	2016	Bone Research2016，4，2：	6
2	Hypoglycaemia and dementia in diabetic patients显示文摘	Bauduceau B Doucet J Bordier L	2010	Diabetes Metab2010，36，13：	1
3	Persistent organic pollutant residues in human fetal liver and placenta from Greater Montreal, Quebec : a longitudinal study from 1998 through 2006 显示文摘	Doucet J Tague B Arnold D L	2009	Environ Health Perspect2009，117，4：	1
4	Neuromuscular electrical stimulation for skeletal muscle function显示文摘	Doucet BM Lam A Griffin L	2012	Yale J Biol Med2012，85，2：	1
5	Subjective Identities and Identity Communication Processes in Information Technology Teams显示文摘	Thatcher S M B Doucet L Tuncel E	2003	Research on Managing Groups and Teams2003，，5：	1
6	Persistent organic pollutant residues in human fetal liver and placenta from Greater Montreal, Quebec: A longitudinal study from 1998 through 2006显示文摘	Doucet J Tague B Arnold D L	2009	Environ Health Perspect2009，117，4：	1
7	Hydrodynamics characterization of rotor-stator mixer with viscous fluids显示文摘	Doucet L Ascanio G Tanguy PA	2005	Chemical Engineering Research andDesign2005，83，10：	1
8	Complications of cardiac catheterization in the current era: A single-center experience显示文摘	Chandrasekar B Doucet S Bilodeau L	2001	Catheter Cardiovasc Interv2001，52，：	1
9	Composition of the Lithospheric Mantle in the Siberian Craton : New Constraints from Fresh Peridotites in the Udachnaya-East Kimberlite 显示文摘	IONOV D A DOUCET L S ASHCHEPKOV I V	2010	Journal of Petrology2010，51，11：	1
10	The Origin of Coarse Garnet Peridotites in Cratonic Litho- sphere:New Data on Xenoliths from the Udaehnaya Kimberlite, Central Siberia显示文摘	DOUCET L S IONOV D A GOLOVIN A V	2013	Contributions to Min- eralogy and Petrology2013，165，6：	1
11	Radioimmuno assay of a New Angiotensin-Converting Enzyme-Inhibi- tor (Perindopril) in Human Plasma and Urine- Advanta- ges of Coupling Anion-Exchange Column Chromatogra- phy with Radioimmunoassay显示文摘	Doucet L Deveyrac B Delaage M	1990	Journal of Pharmaceu- tical Sciences1990，79，8：	1
12	Neuromuscular electrical stim-ulation for skeletal muscle function 显示文摘	Doucet BM Lam A Griffin L	2012	Yale J Biol Med2012，85，2：	1
13	Enhancement of angiozgenesis by bFGF in mandibular bone graft healing in the rabbit显示文摘	EPPLEY B L DOUCET M CONNOLLY D	1988	J Oral Maxillofac Surg1988，46，3：	1
14	Regional and laminar density of the dopamine innervation in adult rat cerebral cortex显示文摘	Descarries L Lemay B Doucet G	1987	Neuroscience1987，21，3：	1
15	Complications of cardiac catheterization in the current era:a single center experience显示文摘	Chandrasekar B Doucet S Bilodeau L	2001	Catheter Cardiovase Interv2001，52，3：	1
16	Hypoglycemia and dementia in diabetic patients 显示文摘	Bauduceau B Doucet J Bordier L	2010	Diabetes Metab2010，36，3：	1
17	A contemporary experience of open aortic reconstruction in patients with chronic atherosclerotic occlusion of the abdominal aorta显示文摘	West CA Jr Johnson LW Doucet L	2010	J Vasc Surg2010，52，5：	1
18	Enhancement of angiogenesis by bFGF in mandibular bone graft healing in the rabbit 显示文摘	Eppley B L Doucet M Connolly D T	1988	J Oral Maxillofac Surg1988，46，5：	1
19	Regional and laminar density of the dopamine innervation in adult rat cerebral cortex 显示文摘	Descarries L Lemay B Doucet G	1987	Neuro- science1987，21，：	1
20	ttydrodynamics Characterization of Rotor-Stator Mixer With Viscous Flu- ids 显示文摘	Doucet L Ascanio G A Tanguy P A	2005	Chemical Engineering Research and Design2005，83，11：	1

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