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| 1 | Role of frailty and sarcopenia in predicting outcomes among patients undergoing gastrointestinal surgery显示文摘According to the United States census bureau 20% of Americans will be older than 65 years in 2030 and half of them will need an operation- equating to about 36 million older surgical patients. Older adults are prone to complications during gastrointestinal cancer treatment and therefore may need to undergo special pretreatment assessments that incorporate frailty and sarcopenia assessments. A focused, structured literature review on Pub Med and Google Scholar was performed to identify primary research articles, review articles, as well as practice guidelines on frailty and sarcopenia among patients undergoing gastrointestinal surgery. The initial search identified 450 articles; after eliminating duplicates, reports that did not include surgical patients, case series, as well as case reports, 42 publications on the impact of frailty and/or sarcopenia on outcome of patients undergoing gastrointestinal surgery were included. Frailty is defined as a clinically recognizable state of increased vulnerability to physiologic stressors resulting from aging. Frailty is associated with a decline in physiologic reserve and function across multiple physiologic systems. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. Unlike cachexia, which is typically associated with weight loss due to chemotherapy or a general malignancy-related cachexia syndrome, sarcopenia relates to muscle mass rather than simply weight. As such, while weight reflects nutritional status, sarcopenia- the loss of muscle mass- is a more accurate and quantitative global marker of frailty. While chronologic age is an important element in assessing a patient's peri-operative risk, physiologic age is a more important determinant of outcomes. Geriatric assessment tools are important components of the preoperative work-up and can help identify patients who suffer from frailty. Such data are important, as frailty and sarcopenia have repeatedly been demonstrated among the strongest predictors of both short- and longterm outcome following complicated surgical procedures such as esophageal, gastric, colorectal, and hepatopancreatico-biliary resections. | doris wagner mara mcadams demarco neda amini stefan buttner dorry segev faiz gani timothy m pawlik | 2016 | World Journal of Gastrointestinal Surgery2016，8，1： | 8 |
| 2 | Comparison of high-resolution ultrasound and MR-enterography in patients with inflammatory bowel disease显示文摘AIM:To compare the results of high-resolution ultrasound(HR-US) and magnetic resonance enterography(MRE) examinations in patients with inflammatory bowel disease(IBD).METHODS:The reports of 250 consecutive cases with known IBD,who had an MRE and HR-US examination,were retrospectively analyzed.Using a patient-based approach we evaluated morphological disease features such as affected bowel wall,stenosis,abscess and fistula.The comparison between the two modalities was based on the hypothesis,that any pathological change described in any imaging modality was a true finding,as no further standard of reference was available for complete assessment.RESULTS:Two hundred and fifty examinations representing 207 different patients were evaluated.Both modalities assessed similar bowel wall changes in 65% of the examinations,with more US findings in 11% and more MRE findings in 15%.When the reports were analyzed with regard to 'bowel wall inflammation',US reported more findings in 2%,while MRE reported more findings in 53%.Stenoses were assessed to be identical in 8%,while US found more in 3% and MRE in 29%(P < 0.01).For abscess detection,US showed more findings in 2%(n = 4) while MRE detected more in 6%(n = 16).US detected more fistulas in 1%(n = 2),while MRE detected more in 13%(n = 32)(P < 0.001).The most common reason for no detected pathology by US was a difficult to assess anatomical region(lesser pelvis,n = 72).CONCLUSION:US can miss clinically relevant pathological changes in patients with IBD mostly due to difficulty in assessing certain anatomical regions. | Andreas G Schreyer Cynthia Menzel Chris Friedrich Florian Poschenrieder Lukas Egger Christian Dornia Gabriela Schill Lena M Dendl Doris Schacherer Christl Girlich Ernst-Michael Jung | 2011 | World Journal of Gastroenterology2011，17，8： | 7 |
| 3 | Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4^(-/-) mouse model显示文摘AIM: To study the interleukin-1(IL-1) pathway as a therapeutic target for liver fibrosis in vitro and in vivo using the ATP-binding cassette transporter b4^(-/-)(Abcb4^(-/-)) mouse model.METHODS: Female and male Abcb4^(-/-) mice from 6 to 13 mo of age were analysed for the degree of cholestasis(liver serum tests), extent of liver fibrosis(hydroxyproline content and Sirius red staining) and tissue-specific activation of signalling pathways such as the IL-1 pathway [quantitative polymerase chain reaction(q PCR)]. For in vivo experiments, murine hepatic stellate cells(HSCs) were isolated via pronasecollagenase perfusion followed by density gradient centrifugation using female mice. Murine HSCs were stimulated with up to 1 ng/m L IL-1β with or without 2.5 μg/m L Anakinra, an IL-1 receptor antagonist, respectively. The proliferation of murine HSCs was assessed via the Brd U assay. The toxicity of Anakinra was evaluated via the fluorescein diacetate hydrolysis(FDH) assay. In vivo 8-wk-old Abcb4^(-/-) mice with an already fully established hepatic phenotype were treated with Anakinra(1 mg/kg body-weight daily intraperitoneally) or vehicle and liver injury and liver fibrosis were evaluated via serum tests, q PCR, hydroxyproline content and Sirius red staining. RESULTS: Liver fibrosis was less pronounced in males than in female Abcb4^(-/-) animals as defined by a lower hydroxyproline content(274 ± 64 μg/g vs 436 ± 80 μg/g liver, respectively; n = 13-15; P < 0.001; MannWhitney U-test) and lower m RNA expression of the profibrogenic tissue inhibitor of metalloproteinase-1(TIMP)(1 ± 0.41 vs 0.66 ± 0.33 fold, respectively; n = 13-15; P < 0.05; Mann-Whitney U-test). Reduced liver fibrosis was associated with significantly lower levels of F4/80 m RNA expression(1 ± 0.28 vs 0.71 ± 0.41 fold, respectively; n = 12-15; P < 0.05; Mann-Whitney U-test) and significantly lower IL-1β m RNA expression levels(1 ± 0.38 vs 0.44 ± 0.26 fold, respectively; n = 13-15; P < 0.001; Mann-Whitney U-test). No gender differences in the serum liver parameters [bilirubin; alanine aminotransferase(ALT); aspartate aminotransferase and alkaline phosphatase(AP)] were found. In vitro, the administration of IL-1β resulted in a significant increase in HSC proliferation [0.94 ± 0.72 arbitrary units(A.U.) in untreated controls, 1.12 ± 0.80 A.U. at an IL-1β concentration of 0.1 ng/m L and 1.18 ± 0.73 A.U. at an IL-1β concentration of 1 ng/m L in samples from n = 6 donor animals; P < 0.001; analyses of variance(ANOVA)]. Proliferation was reduced significantly by the addition of 2.5 μg/m L Anakinra(0.81 ± 0.60 A.U. in untreated controls, 0.92 ± 0.68 A.U. at an IL-1β concentration of 0.1 ng/m L, and 0.91 ± 0.69 A.U. at an IL-1β concentration of 1 ng/m L; in samples from n = 6 donor animals; P < 0.001; ANOVA) suggesting an anti-proliferative effect of this clinically approved IL-1 receptor antagonist. The FDH assay showed this dose to be non-toxic in HSCs. In vivo, Anakinra had no effect on the hepatic hydroxyprolinecontent, liver serum tests(ALT and AP) and profibrotic(collagen 1α1, collagen 1α2, transforming growth factor-β, and TIMP-1) and anti-fibrotic [matrix metalloproteinase 2(MMP2), MMP9 and MMP13 ] gene expression after 4 wk of treatment. Furthermore, the hepatic IL-1β and F4/80 m RNA expression levels were unaffected by Anakinra treatment.CONCLUSION: IL-1β expression is associated with the degree of liver fibrosis in Abcb4^(-/-) mice and promotes HSC proliferation. IL-1 antagonism shows antifibrotic effects in vitro but not in Abcb4^(-/-) mice. | Florian P Reiter Ralf Wimmer Lena Wottke Renate Artmann Jutta M Nagel Manuel O Carranza Doris Mayr Christian Rust Peter Fickert Michael Trauner Alexander L Gerbes Simon Hohenester Gerald U Denk | 2016 | World Journal of Hepatology2016，8，8： | 3 |
| 4 | Comparison of the comet assay and the oxygen microelectrode for measuring tumor oxygenation in head-and-neck cancer patients显示文摘 | Le Q T Kovacs M S Dorie M J | 2003 | Int J Radiat Oncol Biol Phys2003，56，2： | 1 |
| 5 | Conceptual modeling in systems biology fosters empirical findings: The mRNA lifecycle显示文摘 | Dori D Choder M | 2007 | PLoS ONE2007，2，9： | 1 |
| 6 | Trichostatin A reverses skewed expression of CD154,interleukin-10 and interferon-g gene and protein expression in lupus T cells显示文摘 | Nilamadhab M Doris R B Irene M | 2001 | Proc Natl Acad Sci USA2001，98，5： | 1 |
| 7 | Offactory functions in Parkinson's disease subtypes显示文摘 | Dory RL Dotti M | 1994 | Neurology1994，44，： | 1 |
| 8 | Application of the fat aciditytest as an index of grain deterioration 显示文摘 | BAKER DORIS NEUSTADT M H | 1957 | Cereal Chem1957，34，： | 1 |
| 9 | Evaluation of scratch resistance in multiphase PP blends显示文摘 | THOMAS K DORIS M | 2007 | Polym Test2007，26，： | 1 |
| 10 | Association of reactive oxygen species levelsand radioresistance in cancer stem cells显示文摘 | Diehn M Cho RW Lobo NA Kalisky T Dorie MJ KulpAN | 2009 | Nature2009，458，7239： | 1 |
| 11 | Field of needs: the genetics of stroke 显示文摘 | Boerwinkle E Doris PA Fornage M | 1999 | Circulation1999，99，： | 1 |
| 12 | Best cases from the AFIP:congenital intracranial teratoma显示文摘 | SANDOW B A DORY C E AGUIAR M A | 2004 | Radiographics2004，24，4： | 1 |
| 13 | Hypoxia links ATR and p53 through replication Arrest显示文摘 | DENKO N C DORIE M J | 2002 | Mol Cell Biol2002，22，6： | 1 |
| 14 | Relation between macular morphology and visual function in patients with choroidal neovascularisation of age related macular degeneration显示文摘 | Doris N Hart PM Chakravarthy U McCleland J Stevenson M Hudson C | 2001 | Br J Ophthalmol2001，85，： | 1 |
| 15 | Free amino acid content of chicken muscle from broilers and hens显示文摘 | Julius H M Dawson L E Doris H B | 1965 | Jouenal of Food Science1965，30，3： | 1 |
| 16 | Chemokine induced migration of human mesenchymal stem cells:A strategy for directing cardiac repair显示文摘 | Bolno PB Doris M AndrewW | 2004 | Cardiothoracic Surgery Ⅱ2004，199，3： | 1 |
| 17 | Mesenchymal stem cell:A strategy for directing cardiac repair显示文摘 | Pau BB Doris M Andrew W | 2004 | Cardiothorac SurgⅡ2004，199，35： | 1 |
| 18 | Quality monitoring for multipath affected GPS signals显示文摘 | Fantino M Doris F Wang J | 2005 | Journal of Global Positioning Systems2005，4，12： | 1 |
| 19 | Job satisfaction and its relationship to demographics and turnover of hotel food-service workers in Hong Kong 显示文摘 | Connie M Dori Ann F | 1986 | International Journal of Hospitality Management1986，，： | 1 |
| 20 | Differential expression of cytokines and chemokines in human monocytes induced by lipid formulations of amphotericin B显示文摘 | Simitsopoulou M Roilides E Doris J | 2005 | Antimicrob Agents Chemother2005，49，4： | 1 |
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