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	题名	作者	年代	出处	被引量
1	人HCN4通道的滞后现象:影响窦房结起搏的潜在决定因素(英文)显示文摘超极化活化环核苷酸门控(hyperpolarization-activated cyclic-nucleotide-gated,HCN)通道参与调制心脏跳动的节律和速率。与HCN1和HCN2有所不同,慢通道HCN4可能不存在电压依赖的滞后现象。本研究采用单细胞膜片钳方法,在稳定转染hHCN4的HEK293细胞上进行电生理记录,观察hHCN4通道是否存在滞后现象,以及cAMP对其的调制作用;同时采用实时定量RT-PCR方法检测窦房结和心房组织中HCNs的表达。电压钳实验结果显示hHCN4电流(Ih)激活随着保持电位超极化的变化而向去极化方向移动。三角电位变化钳(triangular ramp)和动作电位钳的结果也显示了hHCN4的滞后现象。cAMP增加Ih电流幅度,且使电流激活向去极化方向移动,从而改变内源性hHCN4滞后行为。RT-PCR结果显示,人窦房结组织主要表达HCN4,占75%,HCN1占21%,HCN2占3%,HCN3占0.7%。以上结果提示,人窦房结组织主要表达HCN4亚型,hHCN4的Ih存在电压依赖性的滞后现象,且受cAMP调制。由此推断,hHCN4通道的滞后现象可能在窦房结起搏活动中起到了关键作用。	萧永福 Natalie Chandler Halina Dobrzynski Eric S.Richardson Erica M.TenBroek Joshua J.Wilhelm Vinod Sharma Anthony Varghese Mark R.Boyett Paul A.Iaizzo Daniel C.Sigg	2010	生理学报2010，62，1：	10
2	New insights into pace- maker activity: promoting understanding of sick sinus syndrome 显示文摘	Dobrzynski H Boyett MR Anderson RH	2007	Circulation2007，115，：	1
3	Acoustic band structure of peri- odic elastic composites 显示文摘	Kushwaha M S Halevi P Dobrzynski L Djafari-Rouhani B	1993	Physical Review Letters1993，71，13：	1
4	Transverse elastic waves in periodically layered infinite and semi-infinite media 显示文摘	Camley R E Diafar-Rouhani B Dobrzynski L Maradudin A A	1983	Physical Review B1983，27，12：	1
5	Acoustic band structure of periodic elastic com- posites 显示文摘	KUSHWAHA M S HALEVI P DOBRZYNSKI L	1993	Physical Review Letters1993，71，13：	1
6	Kallikrein gene delivery improves serum glucose and lipid profiles and cardiac function in streptozotocin-induced diabetic rats显示文摘	Montanari D Yin H Dobrzynski E	2005	Diabetes2005，54，6：	1
7	Kallikrein gene delivery improves serum glucose and lipid profiles and cardiac function in streptozotocin-induced diabetic rats显示文摘	Montanari D Yin H Dobrzynski E	2005	Diabetes2005，54，15：	1
8	Extended a- trial conduction system characterized by the expression of the HCN4 channel and connexin45 显示文摘	Yamamoto M Dobrzynski H Tellez J	2006	Cardiovasc Res2006，72，2：	1
9	Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size显示文摘	LYASHKOV A E JUHASZOVA M DOBRZYNSKI H	2007	Circ Res2007，100，12：	1
10	Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size显示文摘	Lyashkov AE Juhaszova M Dobrzynski H	2007	Circ Res2007，100，：	1
11	Almost 40 Years of Airframe Noise ResearchWhat Did We Achieve显示文摘	Dobrzynski W		0，，02：	1
12	Almost 40 years of airframe noise re- search-what did we achieve显示文摘	DOBRZYNSKI W	2010	Journal of aircraft2010，47，2：	1
13	Shape memory behavior of novel (lactide-glycolide- trimethylene carbonate) terpolymers 显示文摘	Dobrzynski P	2007	Biomacromolecules2007，8，：	1
14	Research at DLR Towards Airframe Noise Prediction and Reduction显示文摘	Dobrzynski W Ewert R Pott-Pollenske M		0，，12：	1
15	Organisation of the mouse sinoatrial node: structure and expression of HCN channels 显示文摘	Liu J Dobrzynski H Yanni J	2007	Cardiovasc Res2007，73，4：	1
16	Acoustic band structure of periodic elastic composites 显示文摘	Kushwaha M S Halevi P Dobrzynski L Djafari-Rouhani B	1993	Physical Review Letters1993，71，13：	1
17	Kallikrein gene delivery improves serum glucose and lipid profiles and cardiac function in streptozotoein-induced diabetic rats 显示文摘	Montanari D Yin H Dobrzynski E	2005	Diabetes2005，54，5：	1
18	Melanoma cell spreading on fibronectin induced by 12 (S)-HETE involves both protein kinase-C and protein tyrosine kinase-dependent focal adhesion formation and tyrosine phosphorylatiou of focal adhesion kinase (pp125FAK)显示文摘	Tang D G Tarrien M Dobrzynski P	1995	J Cell Physio[1995，162，2：	1
19	Influence of chain microstructure on the hydrolytic degradation of copolymers from 1,3-trimethylene carbonate and L-lactide显示文摘	Hua JJ Gebarowska K Dobrzynski P	2009	J Polymer Sci Polymer Chem2009，47，15：	1
20	Defect modes in one-dimensional comblike photonic waveguides显示文摘	VASSEUR J O DJAFARI-ROUHANI B DOBRZYNSKI L	1999	Phys Rev B1999，59，13：	1

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