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| 1 | Early diabetic neuropathy:Triggers and mechanisms显示文摘Peripheral neuropathy, and specifically distal peripheral neuropathy (DPN), is one of the most frequent and troublesome complications of diabetes mellitus. It is the major reason for morbidity and mortality among diabetic patients. It is also frequently associated with debilitating pain. Unfortunately, our knowledge of the natural history and pathogenesis of this disease remains limited. For a long time hyperglycemia was viewed as a major, if not the sole factor, responsible for all symptomatic presenta- tions of DPN. Multiple clinical observations and animal studies supported this view. The control of blood glu- cose as an obligatory step of therapy to delay or reverse DPN is no longer an arguable issue. However, while supporting evidence for the glycemic hypothesis has ac- cumulated, multiple controversies accumulated as well. It is obvious now that DPN cannot be fully understood without considering factors besides hyperglycemia. Some symptoms of DPN may develop with little, if any, cor- relation with the glycemic status of a patient. It is also clear that identification of these putative non-glycemic mechanisms of DPN is of utmost importance for our un- derstanding of failures with existing treatments and for the development of new approaches for diagnosis and therapy of DPN. In this work we will review the strengths and weaknesses of the glycemic hypothesis, focusing on clinical and animal data and on the pathogenesis of early stages and triggers of DPN other than hyperglycemia. | Maxim Dobretsov Dmitry Romanovsky Joseph R Stimers | 2007 | World Journal of Gastroenterology2007，13，2： | 55 |
| 2 | The effect of quorum-sensing blockers on the formation of marine microbial communities and larval attachment显示文摘 | Dobretsov S Dahms HU Huang YL Wahl M Qian PY | 2007 | 中国生物学文摘2007，21，6： | 2 |
| 3 | The increase of phospholipid bilayer rigidity after lipid peroxidation显示文摘 | Dobretsov G E Borschevskaya T A Petrov V A | 1977 | FEBS Letters1977，84，： | 1 |
| 4 | 早期糖尿病神经病变:病因与机制显示文摘外周神经病变,尤其是末梢神经病变,是糖尿病最常见而棘手的并发症之一。它是糖尿病患者发病与死亡的主要原因,还常与衰弱性疼痛相关。遗憾的是,我们对糖尿病末梢神经病变自然史与发病机理的了解仍然有限。本文介绍2007年1月《World J Gastroenterol》杂志上有关该病的早期病因与机制。 | Maxim Dobretsov Dmitry Romanovsky Joseph R Stimers | 2007 | 继续医学教育2007，21，5： | 1 |
| 5 | Antibacterial and anti-dia- tom activity of Hong Kong sponges 显示文摘 | Dobretsov S Dahms HU Qian PY | 2005 | Aquatic microbial ecolo- gy2005，38，2： | 1 |
| 6 | Size of a human serum albumin molecule in solution显示文摘 | Kiselev M A Gryzunov IuA Dobretsov G E | 2001 | Biofizika2001，46，： | 1 |
| 7 | Minireview:quorum sensing in the marine environment and its relationship to biofouling显示文摘 | Dobretsov S Teplitski M Paul V | | 0，，： | 1 |
| 8 | Antibacterial and anti-diatom activity of Hong Kong sponges显示文摘 | Sergey Dobretsov Hans-Uwe Dahms Pei-Yuan Qian | 2005 | Aquat Microb Ecol2005，38，： | 1 |
| 9 | Characterization of proteolytic bacteria from the Aleutian deep-sea and their proteases显示文摘 | Hairong Xiong Linsheng Song Ying Xu Man-Yee Tsoi Sergey Dobretsov Pei-Yuan Qian | 2007 | Journal of Industrial Microbiology & Biotechnology2007，，1： | 1 |
| 10 | Serum albumin in systemic inflammatory reaction syndrome显示文摘 | Rodoman GV Shalaeva TI Dobretsov GE | 2006 | Anesteziol Reanimatol2006，，2： | 1 |
| 11 | Evolutions of structures of the Urals, Kazakhstan, Tien Shah, and Altay-Sayan region within the Ural-Mongolian fold belt 显示文摘 | Dobretsov N L | 2003 | Russian Geology and Geophysics2003，44，： | 1 |
| 12 | Pharmacological induction of larval settlement and metamorphosis in the blue mussel Mytilus edulis L显示文摘 | DOBRETSOV S V QIAN P Y | 2003 | Biofouling2003，19，： | 1 |
| 13 | Fragments of oceanic islands in the Kurai and Katun' accretionary wedges of Gorny Altai 显示文摘 | Dobretsov N L Busloy M M Safonova I Y | 2004 | Russian Geolgy and Geophiysics2004，45，： | 1 |
| 14 | The effect of bacterial and diatom biofilms on the settlement of the bryozoan Bugula neritina 显示文摘 | DAHMS H U DOBRETSOV S QIAN P Y | 2004 | Journal of Experimental Marine Biology and Ecolo- gy2004，313，1： | 1 |
| 15 | Opening and Tectonic Evolution of the Paleo-Asian Ocean显示文摘 | Dobretsov N Berzin N Buslov M | 1995 | International Geology Review1995，37，4： | 1 |
| 16 | Opening and tectonic evolution of the Paleo-Asian ocean显示文摘 | Dobretsov N L Berzin N A Buslov M M | 1995 | International Geology Review1995，37，： | 1 |
| 17 | Blueschist belts in Asia and possible periodicity of blueschist facies meta morphism显示文摘 | Dobretsov N L Coleman R G Liou N G | 1987 | Ofiloliti1987，12，： | 1 |
| 18 | Geotectonic e volution of diamondiferous paragneisses,Kokehetav Complex, northern Kazakhstan: The geologic enigma of ultrahigh-pres sure crustal rocks within a Paleozoic foldbelt显示文摘 | Dobretsov N L Sobolev N V Shatsky V S | 1995 | Island Arc1995，4，4： | 1 |
| 19 | Mechanical hyperalgesia in rats with chronic perfusion of lumbar dorsal root ganglion with hyperglycemic solution显示文摘 | DOBRETSOV M HASTINGS S L STIMERS J R | 2001 | J Neurosci Methods2001，30，12： | 1 |
| 20 | Geotectonic evolution of diamondiferous paragneisses of the Kokchetav complex, northern Kazakhstan-The geologic enigma of ultra-high pressure crustal rocks within a Palaeozoic foldbeh显示文摘 | DOBRETSOV N L SOPOLEV N V SHATSKY V S | 1995 | Isl Arc1995，4，： | 1 |
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