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| 1 | Understanding the importance of autophagy in human diseases using Drosophila显示文摘Autophagy is a lysosome-dependent intracellular degradation pathway that has been implicated in the pathogenesis of various human diseases, either positively or negatively impacting disease outcomes depending on the specific context. The majority of medical conditions including cancer, neurodegenerative diseases, infections and immune system disorders and inflammatory bowel disease could probably benefit from therapeutic modulation of the autophagy machinery. Drosophila represents an excellent model animal to study disease mechanisms thanks to its sophisticated genetic toolkit, and the conservation of human disease genes and autophagic processes. Here, we provide an overview of the various autophagy pathways observed both in flies and human cells(macroautophagy, microautophagy and chaperone-mediated autophagy), and discuss Drosophila models of the above-mentioned diseases where fly research has already helped to understand how defects in autophagy genes and pathways contribute to the relevant pathomechanisms. | Arindam Bhattacharjee áron Szabó Tamás Csizmadia Hajnalka Laczkó-Dobos Gábor Juhász | 2019 | Journal of Genetics and Genomics2019，46，4： | 4 |
| 2 | So|ring the search for source code显示文摘 | STOLEE K T ELBAUM S DOBOS D | 2014 | ACM Transactions on Software Engineering and Methodology2014，23，3： | 1 |
| 3 | Modification of iono- tropic glutamate receptor-mediated processes in the rat hippocampus following repeated, brief seizures显示文摘 | Borbely S Dobo E Czege D | 2009 | Neuro- science2009，159，1： | 1 |
| 4 | O-manno- sylation of the Mycobacterium tuberculosis adhesin Apa is crucial for T cell antigenicity during infection but is expendable for pro- tection 显示文摘 | Nandakumar S Kannanganat S Dobos KM | 2013 | PLoS Pathog2013，9，10： | 1 |
| 5 | Thermal degradation of poly (tetramethyl-p-silphenylene) and poly(tetramethyl-p-silphenylenesiloxane)显示文摘 | Zelei B Blazso M Dobos S | 1981 | European Polymer Journal1981，17，： | 1 |
| 6 | Demonstration of components of antigen 85 complex in cerebrospinal fluid of tuberculous meningitis patients显示文摘 | Kashyap R S Dobos K M Belisle J T | | 0，，06： | 1 |
| 7 | Demonstration of components of antigen 85 complex in cerebrospinal fluid of tuberculous meningitis patients显示文摘 | Kashyap R S Dobos K M Belisle J T | 2005 | Clin Diagn Lab Immunol2005，12，6： | 1 |
| 8 | Demonstration of components of antigen 85 complex in cerebrospinal fluid of tuberculous meningitis patients 显示文摘 | Kashyap R S Dobos K M Bellsle J T | 2005 | Clin Diagn Lab Immunol2005，12，6： | 1 |
| 9 | Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential显示文摘 | Tsujii M Kawano S Dobo RN | 1997 | Proc Natl Sci USA1997，94，7： | 1 |
| 10 | Optimum crop densities for potential yield and harvestable yield of grain amaranth are conflicting显示文摘 | GIMPLINGER D M ERLEY G S DOBOS G | 2008 | Europ JAgronomy2008，28，2： | 1 |
| 11 | Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain 显示文摘 | GU S CHEN J DOBOS K M | 2003 | Molecular & Cellular Proteomics2003，2，12： | 1 |
| 12 | Comprehensive proteomic profiling of the membrane constituents of a Mycobacteri- um tuberculosis strain 显示文摘 | Gu S Chen J Dobos KM | 2003 | Mol Cell Proteomics2003，2，12： | 1 |
| 13 | Mannosylation of the mycobacterium tuberculosis adhesin apa is crucial for T cell antigenicity during infection but Is expendable for pro- tection 显示文摘 | Nandakumar S Kannanganat S Dobos KM | 2013 | PLoS Pathog2013，9，10： | 1 |
| 14 | Effectsof phlebotomy - induced reduction of body iron stores onmetabolic syndrome : results from a randomized clinical trial显示文摘 | HOUSCHYAR K S LUDTKE R DOBOS G J | 2012 | BMC Med2012，10，： | 1 |
| 15 | Cyclooxygenase-2 experssion in human colon cancer cells increases metastatic potential显示文摘 | Tsujii M Kawano S DoBo R N | 1997 | Proc Natl Sci USA1997，94，7： | 1 |
| 16 | A different cardiac resynchronization therapy technique might be needed in some patients with nonspecific intraventricular conduction disturbance pattern显示文摘BACKGROUND Current cardiac resynchronization therapy(CRT),devised to eliminate dyssynchrony in left bundle branch block(LBBB),works by pacing the latest activated left ventricular site(LALVS).We hypothesized that patients with nonspecific intraventricular conduction disturbance(NICD)pattern respond less favorably to CRT,because their LALVS is far away from that in LBBB.METHODS By measuring the amplitude and polarity of secondary ST-segment alterations in two optional frontal and hori-zontal surface electrocardiogram(ECG)leads and using a software,we determined the resultant 3D spatial secondary ST vector,which is directed 180o away from the LALVS,in 110 patients with LBBB pattern and 77 patients with NICD pattern and heart failure.To validate the ECG method,we also estimated the LALVS by echocardiography using 3D parametric imaging and 2D speckle tracking in 22 LBBB patients and 20 NICD patients.Patients with NICD pattern were subdivided according to their non-overlapping frontal plane resultant secondary ST vector ranges to the NICD-1 subgroup(n=44)and the NICD-2 subgroup(n=33).RESULTS Based on the software determined coordinates of the resultant 3D spatial secondary ST vector directed 180o away from the LALVS,the LALVSs were located leftward,posterosuperior in the LBBB group,slightly left,superior in the NICD-1 sub-group,and slightly left,posteroinferior in the NICD-2 subgroup.The LALVS determined by ECG and echocardiography matched in all patients,except two.CONCLUSIONS In the NICD-2 subgroup,a remote LALVS was found from that in LBBB pattern,which might explain the high non-response rate of the NICD pattern to the current CRT technique. | Gábor Katona Zsuzsanna Szelényi Gábor Szénási Bálint Kozman Zsolt Rekvényi Luca Kópházi Zsolt Dobos Szilvia Vereckei András Vereckei | 2021 | Journal of Geriatric Cardiology2021，18，12： | 0 |
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